Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NME1
  • Mouse genes Nme1
  • Rat genes Nme1
  • Zfish genes nme2b.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nme1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	NME1	IDA		Human	PMID:12972261
Molecular Function	GO:0004536	DNA nuclease activity	NME1	IDA		Human	PMID:11555662
Molecular Function	GO:0019899	enzyme binding	Nme1	IPI	RGD:621248	Rat	PMID:16026327|RGD:5132881
Molecular Function	GO:0019899	enzyme binding	Nme1	IPI	RGD:2997	Rat	PMID:17572440|RGD:5132880
Molecular Function	GO:0043015	gamma-tubulin binding	Nme1	IDA		Rat	PMID:11139339|RGD:70281
Molecular Function	GO:0005525	GTP binding	NME1	IDA		Human	PMID:12972261
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:10602478
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:17314099
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:25910212
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	NME1	IPI	UniProtKB:P15531	Human	PMID:32296183
Molecular Function	GO:0019215	intermediate filament binding	Nme1	IPI	RGD:2679	Rat	PMID:11082283|RGD:2299080
Molecular Function	GO:0000287	magnesium ion binding	NME1	IDA		Human	PMID:11555662
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	NME1	IDA		Human	PMID:12972261
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	NME1	IDA		Human	PMID:9488696
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	Nme1	IDA		Rat	PMID:11139339|RGD:70281
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	nme2b.1	IMP	ZFIN:ZDB-MRPHLNO-091119-1	Zfish	PMID:19805292
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q86TP1	Human	PMID:10602478
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P54274-2	Human	PMID:11701125
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q61097	Human	PMID:15684389
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O00746	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O15160	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q13232	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q96HA8	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P22392	Human	PMID:17314099
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q9Y3F4	Human	PMID:17314099
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P03372	Human	PMID:17975005
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P10911	Human	PMID:18470881
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P10911:PRO_0000030434	Human	PMID:18470881
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P51116	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q96HA8	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P51116	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O15160	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P22392	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O00746	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O14787	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O15160	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q13232	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q7Z2X4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q8N9Q2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O00746	Human	PMID:27499296
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O00746	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O15160	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P51116	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q13232	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q96HA8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P22392	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O00746	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:O15160	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:P61970	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NME1	IPI	UniProtKB:Q9Y5L0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nme1	IPI	RGD:736443	Rat	PMID:11302744|RGD:2317277
Molecular Function	GO:0005515	protein binding	Nme1	IPI	UniProtKB:O00255-2	Rat	PMID:11302744|RGD:2317277
Molecular Function	GO:0005515	protein binding	Nme1	IPI	RGD:620183	Rat	PMID:11872741|RGD:727348
Molecular Function	GO:0019901	protein kinase binding	Nme1	IPI	RGD:3387	Rat	PMID:16026327|RGD:5132881
Molecular Function	GO:0043024	ribosomal small subunit binding	NME1	IPI	UniProtKB:P23396	Human	PMID:16814409
Molecular Function	GO:0003723	RNA binding	NME1	HDA		Human	PMID:22658674
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nme1	IDA		Rat	PMID:12010125|RGD:633207
Molecular Function	GO:0003697	single-stranded DNA binding	Nme1	IDA		Rat	PMID:12010125|RGD:633207
Cellular Component	GO:0005813	centrosome	Nme1	IDA		Rat	PMID:11139339|RGD:70281
Cellular Component	GO:0005829	cytosol	NME1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	NME1	IDA		Human	PMID:16814409
Cellular Component	GO:0005829	cytosol	Nme1	IDA		Rat	PMID:11831846|RGD:2299079
Cellular Component	GO:0070062	extracellular exosome	NME1	HDA		Human	PMID:23533145
Cellular Component	GO:0005882	intermediate filament	Nme1	IDA		Rat	PMID:11082283|RGD:2299080
Cellular Component	GO:0016020	membrane	NME1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Nme1	IDA		Rat	PMID:11872741|RGD:727348
Cellular Component	GO:0005741	mitochondrial outer membrane	Nme1	IDA		Rat	PMID:22817458|RGD:10047196
Cellular Component	GO:0005739	mitochondrion	Nme1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Nme1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	NME1	IDA		Human	PMID:16814409
Cellular Component	GO:0005634	nucleus	NME1	HDA		Human	PMID:21630459
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nme1	IDA		Rat	PMID:11082283|RGD:2299080
Cellular Component	GO:0032587	ruffle membrane	NME1	IDA		Human	PMID:16814409
Biological Process	GO:0071398	cellular response to fatty acid	Nme1	IEP		Rat	PMID:19367376|RGD:5132883
Biological Process	GO:0071333	cellular response to glucose stimulus	Nme1	IEP		Rat	PMID:19367376|RGD:5132883
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Nme1	IEP		Rat	PMID:11082283|RGD:2299080
Biological Process	GO:0006183	GTP biosynthetic process	Nme1	IDA		Rat	PMID:11139339|RGD:70281
Biological Process	GO:0006183	GTP biosynthetic process	nme2b.1	IMP	ZFIN:ZDB-MRPHLNO-091119-1	Zfish	PMID:19805292
Biological Process	GO:0021766	hippocampus development	Nme1	IEP		Rat	PMID:18493952|RGD:2302825
Biological Process	GO:0007595	lactation	Nme1	IMP	MGI:MGI:3628812	Mouse	PMID:12848338
Biological Process	GO:0030879	mammary gland development	Nme1	IMP	MGI:MGI:3628812	Mouse	PMID:12848338
Biological Process	GO:0010629	negative regulation of gene expression	Nme1	IDA		Rat	PMID:12010125|RGD:633207
Biological Process	GO:0002762	negative regulation of myeloid leukocyte differentiation	Nme1	IDA		Rat	PMID:7737424|RGD:2299083
Biological Process	GO:0043388	positive regulation of DNA binding	NME1	IDA		Human	PMID:17975005
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	NME1	IMP		Human	PMID:16862176
Biological Process	GO:0010976	positive regulation of neuron projection development	Nme1	IMP		Rat	PMID:10069391|RGD:5132899
Biological Process	GO:0045765	regulation of angiogenesis	nme2b.1	IMP	ZFIN:ZDB-MRPHLNO-091119-1	Zfish	PMID:25147336
Biological Process	GO:0014075	response to amine	Nme1	IEP		Rat	PMID:19639176|RGD:5132866
Biological Process	GO:0051591	response to cAMP	Nme1	IEP		Rat	PMID:11082283|RGD:2299080
Biological Process	GO:0033574	response to testosterone	Nme1	IEP		Rat	PMID:19639176|RGD:5132866
Biological Process	GO:0009410	response to xenobiotic stimulus	Nme1	IEP		Rat	PMID:11082283|RGD:2299080

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern