Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nme2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NME1-NME2,NME2,NME2P1
- Mouse genes Nme2
- Rat genes Nme2
- Zfish genes nme2a,nme2b.1,nme2b.2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nme2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	NME2	IDA		Human	PMID:19435876
Molecular Function	GO:0019899	enzyme binding	Nme2	IPI	RGD:2996	Rat	PMID:17572440\|RGD:5132880
Molecular Function	GO:0005504	fatty acid binding	Nme2	IPI	CHEBI:15843	Rat	PMID:18084788\|RGD:5132873
Molecular Function	GO:0051880	G-quadruplex DNA binding	NME2	IDA		Human	PMID:25679041
Molecular Function	GO:0019003	GDP binding	NME2	IMP		Human	PMID:19435876
Molecular Function	GO:1901363	heterocyclic compound binding	Nme2	IPI	CHEBI:59039	Rat	PMID:1316151\|RGD:729254
Molecular Function	GO:0042802	identical protein binding	Nme2	IPI	RGD:619877	Rat	PMID:1316152\|RGD:5133244
Molecular Function	GO:0019215	intermediate filament binding	Nme2	IPI	RGD:2679	Rat	PMID:11082283\|RGD:2299080
Molecular Function	GO:0019215	intermediate filament binding	Nme2	IPI	RGD:621646	Rat	PMID:11082283\|RGD:2299080
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	NME2	IDA		Human	PMID:1851158
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	NME2	IDA		Human	PMID:25679041
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	NME2	IDA		Human	PMID:9488696
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	Nme2	IDA		Rat	PMID:8142475\|RGD:2299082
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	nme2b.1	IMP	ZFIN:ZDB-MRPHLNO-091119-1	Zfish	PMID:19805292
Molecular Function	GO:0004550	nucleoside diphosphate kinase activity	nme2b.2	IMP	ZFIN:ZDB-MRPHLNO-091119-2	Zfish	PMID:19805292
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:O14713	Human	PMID:11919189
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:O14713-1	Human	PMID:11919189
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:P15531	Human	PMID:17314099
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:Q9HD36	Human	PMID:17532299
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:O00746	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:P15531	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:P50570	Human	PMID:24970086
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:O00746	Human	PMID:27499296
Molecular Function	GO:0005515	protein binding	NME2	IPI	UniProtKB:P15531	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Nme2	IPI	UniProtKB:P09055	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Nme2	IPI	UniProtKB:Q9Z0F3	Rat	PMID:17532299\|RGD:151356633
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Nme2	IDA		Rat	PMID:9000516\|RGD:5133240
Molecular Function	GO:0003713	transcription coactivator activity	NME2	IDA		Human	PMID:8392752
Cellular Component	GO:0071944	cell periphery	NME2	IDA		Human	PMID:11919189
Cellular Component	GO:0005737	cytoplasm	NME2	IDA		Human	PMID:15703214
Cellular Component	GO:0005737	cytoplasm	NME2	IDA		Human	PMID:17532299
Cellular Component	GO:0070062	extracellular exosome	NME2P1	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	NME2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	NME2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	NME2	HDA		Human	PMID:23533145
Cellular Component	GO:0005882	intermediate filament	Nme2	IDA		Rat	PMID:11082283\|RGD:2299080
Cellular Component	GO:0030027	lamellipodium	NME2	IDA		Human	PMID:11919189
Cellular Component	GO:0031966	mitochondrial membrane	Nme2	IDA		Rat	PMID:11831846\|RGD:2299079
Cellular Component	GO:0005739	mitochondrion	Nme2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Nme2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Nme2	HDA		Mouse	MGI:MGI:3834050\|PMID:17634366
Cellular Component	GO:0005634	nucleus	NME2P1	HDA		Human	PMID:21630459
Cellular Component	GO:0005634	nucleus	NME2	HDA		Human	PMID:21630459
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nme2	IDA		Rat	PMID:11082283\|RGD:2299080
Cellular Component	GO:0001726	ruffle	NME2	IDA		Human	PMID:11919189
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Nme2	IMP		Rat	PMID:17363702\|RGD:2299078
Biological Process	GO:0071398	cellular response to fatty acid	Nme2	IEP		Rat	PMID:19367376\|RGD:5132883
Biological Process	GO:0071333	cellular response to glucose stimulus	Nme2	IEP		Rat	PMID:19367376\|RGD:5132883
Biological Process	GO:0034599	cellular response to oxidative stress	Nme2	IEP		Rat	PMID:18442093\|RGD:5132872
Biological Process	GO:0006241	CTP biosynthetic process	Nme2	IDA		Rat	PMID:1316151\|RGD:729254
Biological Process	GO:0006183	GTP biosynthetic process	Nme2	IDA		Rat	PMID:1316151\|RGD:729254
Biological Process	GO:0006183	GTP biosynthetic process	Nme2	IDA		Rat	PMID:8142475\|RGD:2299082
Biological Process	GO:0006183	GTP biosynthetic process	nme2b.1	IMP	ZFIN:ZDB-MRPHLNO-091119-1	Zfish	PMID:19805292
Biological Process	GO:0006183	GTP biosynthetic process	nme2b.2	IMP	ZFIN:ZDB-MRPHLNO-091119-2	Zfish	PMID:19805292
Biological Process	GO:0007229	integrin-mediated signaling pathway	NME2	IDA		Human	PMID:11919189
Biological Process	GO:0043066	negative regulation of apoptotic process	NME2	IMP		Human	PMID:16862176
Biological Process	GO:0002762	negative regulation of myeloid leukocyte differentiation	Nme2	IDA		Rat	PMID:7737424\|RGD:2299083
Biological Process	GO:0009142	nucleoside triphosphate biosynthetic process	NME2	IDA		Human	PMID:1851158
Biological Process	GO:0009142	nucleoside triphosphate biosynthetic process	NME2	IDA		Human	PMID:25679041
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NME2	IMP		Human	PMID:19435876
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NME2	IDA		Human	PMID:8392752
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	NME2	IMP		Human	PMID:16862176
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	NME2	IMP		Human	PMID:16862176
Biological Process	GO:0010976	positive regulation of neuron projection development	Nme2	IMP		Rat	PMID:10069391\|RGD:5132899
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NME2	IDA		Human	PMID:15703214
Biological Process	GO:0046777	protein autophosphorylation	Nme2	IDA		Rat	PMID:9000516\|RGD:5133240
Biological Process	GO:0045765	regulation of angiogenesis	nme2b.1	IMP	ZFIN:ZDB-MRPHLNO-091119-1	Zfish	PMID:25147336
Biological Process	GO:0045682	regulation of epidermis development	NME2	IMP		Human	PMID:16862176
Biological Process	GO:0060416	response to growth hormone	Nme2	IEP		Rat	PMID:16127721\|RGD:1626369
Biological Process	GO:0006228	UTP biosynthetic process	Nme2	IDA		Rat	PMID:1316151\|RGD:729254

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.