Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NMI
  • Mouse genes Nmi
  • Rat genes Nmi
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nmi

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	NMI	IPI	UniProtKB:Q13287	Human	PMID:21516116
Molecular Function	GO:0042802	identical protein binding	NMI	IPI	UniProtKB:Q13287	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	NMI	IPI	UniProtKB:Q13287	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P01106	Human	PMID:10597290
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P04198	Human	PMID:10597290
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P80217	Human	PMID:10779520
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P80217	Human	PMID:10950963
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O14964	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O75971	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P23434	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8N4P3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9XRX5	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9Y6C2	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O55170	Human	PMID:16214168
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P56693	Human	PMID:16214168
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9HCU9	Human	PMID:16919237
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P42226	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O00463	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O75971	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O95171	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:A8K2R3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O00463	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O75971	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O95171	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O95447	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P40222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q0D2H9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q15013	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q53XL7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q6P9H4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q6PEY2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q86XK3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8N3L3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8N4P3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8TAB5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q96IS6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q96LT7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q96QG7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9H9Q2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9HCU9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9XRX5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9Y217	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9Y6C2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P80217	Human	PMID:26342464
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:A0A0S2Z4Q4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O14964	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O00463	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P80217-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9HCU9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O00463	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O75971-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:O95171-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P23434	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P40222	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P80217-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q5VTT5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q6PEY2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q6PJG6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q6ZMU5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8N3L3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8N4P3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q8NA92	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q96QG7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9H9Q2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:Q9XRX5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P42226	Human	PMID:9989503
Molecular Function	GO:0005515	protein binding	NMI	IPI	UniProtKB:P51692	Human	PMID:9989503
Molecular Function	GO:0005515	protein binding	Nmi	IPI	PR:O35309	Mouse	PMID:23956435
Cellular Component	GO:0005737	cytoplasm	NMI	IDA		Human	PMID:10597290
Cellular Component	GO:0005737	cytoplasm	NMI	IDA		Human	PMID:10950963
Cellular Component	GO:0005737	cytoplasm	NMI	IDA		Human	PMID:9781816
Cellular Component	GO:0005829	cytosol	NMI	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	NMI	IDA		Human	PMID:10779520
Cellular Component	GO:0005829	cytosol	NMI	IDA		Human	PMID:10950963
Cellular Component	GO:0005615	extracellular space	NMI	IDA		Human	PMID:29038465
Cellular Component	GO:0005615	extracellular space	Nmi	IDA		Mouse	MGI:MGI:6099204|PMID:29038465
Cellular Component	GO:0016020	membrane	NMI	IDA		Human	PMID:10950963
Cellular Component	GO:0005654	nucleoplasm	NMI	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NMI	IDA		Human	PMID:10950963
Cellular Component	GO:0005634	nucleus	NMI	IDA		Human	PMID:9781816
Biological Process	GO:0002281	macrophage activation involved in immune response	NMI	IDA		Human	PMID:29038465
Biological Process	GO:0008285	negative regulation of cell population proliferation	NMI	IMP		Human	PMID:29350881
Biological Process	GO:0045824	negative regulation of innate immune response	NMI	IMP		Human	PMID:26342464
Biological Process	GO:0045824	negative regulation of innate immune response	Nmi	IDA		Mouse	PMID:23956435
Biological Process	GO:0032687	negative regulation of interferon-alpha production	Nmi	IMP		Mouse	PMID:23956435
Biological Process	GO:0032688	negative regulation of interferon-beta production	Nmi	IMP		Mouse	PMID:23956435
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	NMI	IDA		Human	PMID:29350881
Biological Process	GO:0032480	negative regulation of type I interferon production	Nmi	IGI	MGI:MGI:1859212	Mouse	PMID:23956435
Biological Process	GO:0050729	positive regulation of inflammatory response	Nmi	IMP		Mouse	MGI:MGI:6099204|PMID:29038465
Biological Process	GO:0045089	positive regulation of innate immune response	Nmi	IMP		Mouse	MGI:MGI:6099204|PMID:29038465
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NMI	IDA		Human	PMID:29038465
Biological Process	GO:1902524	positive regulation of protein K48-linked ubiquitination	Nmi	IDA		Mouse	PMID:23956435
Biological Process	GO:0070936	protein K48-linked ubiquitination	Nmi	IDA		Mouse	PMID:23956435
Biological Process	GO:0009615	response to virus	Nmi	IMP		Mouse	MGI:MGI:5546557|PMID:23956435
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	Nmi	IDA		Mouse	MGI:MGI:6099204|PMID:29038465

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern