Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOD1
  • Mouse genes Nod1
  • Rat genes Nod1
  • Zfish genes nod1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nod1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050700	CARD domain binding	NOD1	IDA		Human	PMID:10329646
Molecular Function	GO:0042802	identical protein binding	NOD1	IDA		Human	PMID:10329646
Molecular Function	GO:0042802	identical protein binding	NOD1	IDA		Human	PMID:10880512
Molecular Function	GO:0042802	identical protein binding	NOD1	IPI	UniProtKB:Q9Y239	Human	PMID:18186648
Molecular Function	GO:0140677	molecular function activator activity	NOD1	IDA		Human	PMID:10880512
Molecular Function	GO:0140677	molecular function activator activity	NOD1	IDA		Human	PMID:11058605
Molecular Function	GO:0038187	pattern recognition receptor activity	NOD1	IDA		Human	PMID:11058605
Molecular Function	GO:0038187	pattern recognition receptor activity	NOD1	IDA		Human	PMID:31649195
Molecular Function	GO:0005515	protein binding	NOD1	IDA		Human	PMID:10880512
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q9NPP4	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q15654	Human	PMID:15657077
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q13098	Human	PMID:17337451
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q7L5N1	Human	PMID:17337451
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q9Y2Z0	Human	PMID:17420470
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q92974	Human	PMID:19043560
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:O43353	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q6UX06	Human	PMID:20534456
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:A0A0H3NF38	Human	PMID:23935490
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:P0CE12	Human	PMID:23935490
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q9Y2Z0	Human	PMID:23935490
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:P02545	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:P14136	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q13153	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q53GS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOD1	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nod1	IPI	PR:Q3UZZ4	Mouse	PMID:20534456
Molecular Function	GO:0042803	protein homodimerization activity	NOD1	IPI	UniProtKB:Q9Y239	Human	PMID:18186648
Molecular Function	GO:0044877	protein-containing complex binding	NOD1	IPI	ComplexPortal:CPX-1870	Human	PMID:17337451
Cellular Component	GO:0016323	basolateral plasma membrane	NOD1	IDA		Human	PMID:19043560
Cellular Component	GO:0005737	cytoplasm	NOD1	IDA		Human	PMID:10329646
Cellular Component	GO:0005829	cytosol	NOD1	IDA		Human	PMID:31649195
Cellular Component	GO:0045335	phagocytic vesicle	Nod1	IDA		Mouse	MGI:MGI:6414746|PMID:31649195
Cellular Component	GO:0005886	plasma membrane	NOD1	IDA		Human	PMID:17970764
Cellular Component	GO:0005886	plasma membrane	NOD1	IMP		Human	PMID:31649195
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	NOD1	IDA		Human	PMID:10329646
Biological Process	GO:0071225	cellular response to muramyl dipeptide	NOD1	IMP		Human	PMID:25093298
Biological Process	GO:0042742	defense response to bacterium	NOD1	IDA		Human	PMID:15653568
Biological Process	GO:0042742	defense response to bacterium	nod1	IMP	ZFIN:ZDB-MRPHLNO-111222-3	Zfish	PMID:21729873
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0051607	defense response to virus	nod1	IMP	ZFIN:ZDB-GENO-180816-8	Zfish	PMID:32169843
Biological Process	GO:0016045	detection of bacterium	NOD1	IDA		Human	PMID:15653568
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0035187	hatching behavior	nod1	IMP	ZFIN:ZDB-GENO-180816-8	Zfish	PMID:28592872
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0032635	interleukin-6 production	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0032635	interleukin-6 production	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0035556	intracellular signal transduction	NOD1	IDA		Human	PMID:15653568
Biological Process	GO:0007254	JNK cascade	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0010934	macrophage cytokine production	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0010934	macrophage cytokine production	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NOD1	IDA		Human	PMID:31649195
Biological Process	GO:0043065	positive regulation of apoptotic process	Nod1	IDA		Rat	PMID:23028889|RGD:9831166
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	NOD1	IDA		Human	PMID:10329646
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Nod1	IMP		Mouse	MGI:MGI:4442557|PMID:20008287
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	NOD1	IDA		Human	PMID:10329646
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nod1	IMP		Rat	PMID:22450316|RGD:9831170
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0032757	positive regulation of interleukin-8 production	NOD1	IDA		Human	PMID:15653568
Biological Process	GO:0046330	positive regulation of JNK cascade	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD1	IDA		Human	PMID:17054981
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD1	IDA		Human	PMID:19043560
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NOD1	IMP		Human	PMID:25093298
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Nod1	IMP		Rat	PMID:22870324|RGD:9831169
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod1	IMP		Rat	PMID:22450316|RGD:9831170
Biological Process	GO:1904417	positive regulation of xenophagy	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:22033934
Biological Process	GO:0043408	regulation of MAPK cascade	nod1	IMP	ZFIN:ZDB-GENO-200316-7	Zfish	PMID:29692779
Biological Process	GO:0051403	stress-activated MAPK cascade	Nod1	IDA		Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Nod1	IGI	MGI:MGI:2429397	Mouse	PMID:18261938
Biological Process	GO:0098792	xenophagy	Nod1	IMP	MGI:MGI:2674231	Mouse	PMID:22033934

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern