Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOG
  • Mouse genes Nog
  • Rat genes Nog
  • Zfish genes nog1,nog3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nog

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019955	cytokine binding	NOG	IPI	UniProtKB:P12643	Human	PMID:8752214
Molecular Function	GO:0019955	cytokine binding	NOG	IPI	UniProtKB:P12644	Human	PMID:8752214
Molecular Function	GO:0005515	protein binding	NOG	IPI	UniProtKB:P12643	Human	PMID:19804412
Molecular Function	GO:0005515	protein binding	NOG	IPI	UniProtKB:P43026	Human	PMID:21976273
Molecular Function	GO:0005515	protein binding	NOG	IPI	UniProtKB:Q13873	Human	PMID:21976273
Molecular Function	GO:0005515	protein binding	NOG	IPI	UniProtKB:P43026	Human	PMID:24098149
Molecular Function	GO:0005515	protein binding	Nog	IPI	RGD:69358	Rat	PMID:15199066|RGD:1599074
Molecular Function	GO:0042803	protein homodimerization activity	NOG	IDA		Human	PMID:11562478
Molecular Function	GO:0044877	protein-containing complex binding	Nog	IDA		Rat	PMID:15199066|RGD:1599074
Cellular Component	GO:0030424	axon	Nog	IDA		Rat	PMID:21447372|RGD:12801487
Cellular Component	GO:0005615	extracellular space	NOG	IDA		Human	PMID:11562478
Cellular Component	GO:0005615	extracellular space	NOG	IDA		Human	PMID:7666191
Cellular Component	GO:0005615	extracellular space	Nog	IDA		Mouse	PMID:24835669
Cellular Component	GO:0005615	extracellular space	Nog	IDA		Mouse	PMID:15110716
Cellular Component	GO:0005615	extracellular space	Nog	IDA		Rat	PMID:15199066|RGD:1599074
Cellular Component	GO:0005794	Golgi apparatus	nog1	IDA		Zfish	PMID:24752827
Cellular Component	GO:0032991	protein-containing complex	Nog	IDA		Rat	PMID:15199066|RGD:1599074
Cellular Component	GO:0045202	synapse	nog1	IDA		Zfish	PMID:24752827
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Nog	IGI	MGI:MGI:88180	Mouse	PMID:16916379
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Nog	IMP		Mouse	PMID:16916379
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0048318	axial mesoderm development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0007411	axon guidance	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:12435358
Biological Process	GO:0030509	BMP signaling pathway	Nog	IDA		Mouse	PMID:17634368
Biological Process	GO:0030509	BMP signaling pathway	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:12397106
Biological Process	GO:0030509	BMP signaling pathway	Nog	IDA		Mouse	PMID:18462699
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0007420	brain development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:12397106
Biological Process	GO:0051216	cartilage development	Nog	IDA		Mouse	PMID:10684250
Biological Process	GO:0021533	cell differentiation in hindbrain	NOG	IMP		Human	PMID:8582276
Biological Process	GO:0008283	cell population proliferation	Nog	IGI	MGI:MGI:104327	Mouse	PMID:12397106
Biological Process	GO:0008283	cell population proliferation	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:12397106
Biological Process	GO:0071773	cellular response to BMP stimulus	Nog	IDA		Mouse	PMID:20501701
Biological Process	GO:0071773	cellular response to BMP stimulus	Nog	IEP		Rat	PMID:21238590|RGD:12801486
Biological Process	GO:0071456	cellular response to hypoxia	Nog	IEP		Rat	PMID:25740156|RGD:12801489
Biological Process	GO:0007417	central nervous system development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:10688202
Biological Process	GO:0035844	cloaca development	nog3	IMP	ZFIN:ZDB-GENO-080731-3	Zfish	PMID:21596840
Biological Process	GO:1904888	cranial skeletal system development	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:12397106
Biological Process	GO:1904888	cranial skeletal system development	Nog	IGI	MGI:MGI:104327	Mouse	PMID:12397106
Biological Process	GO:0007368	determination of left/right symmetry	nog3	IMP	ZFIN:ZDB-GENO-070710-2	Zfish	PMID:18267096
Biological Process	GO:0007368	determination of left/right symmetry	nog3	IMP	ZFIN:ZDB-GENO-070710-2	Zfish	PMID:17395172
Biological Process	GO:0009953	dorsal/ventral pattern formation	NOG	IDA		Human	PMID:7666191
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog3	IMP		Zfish	PMID:9882485
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IGI	ZFIN:ZDB-MRPHLNO-050221-6,ZFIN:ZDB-MRPHLNO-080212-1,ZFIN:ZDB-MRPHLNO-080214-1	Zfish	PMID:16890217
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IGI	ZFIN:ZDB-MRPHLNO-050221-6,ZFIN:ZDB-MRPHLNO-080212-2	Zfish	PMID:16890217
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IMP		Zfish	PMID:15151985
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IGI	ZFIN:ZDB-MRPHLNO-050221-6,ZFIN:ZDB-MRPHLNO-080212-1	Zfish	PMID:16890217
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IMP		Zfish	PMID:10491267
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IGI	ZFIN:ZDB-MRPHLNO-060818-2,ZFIN:ZDB-MRPHLNO-080212-1	Zfish	PMID:16890217
Biological Process	GO:0009953	dorsal/ventral pattern formation	nog1	IGI	ZFIN:ZDB-MRPHLNO-050221-6,ZFIN:ZDB-MRPHLNO-080212-1	Zfish	PMID:20886103
Biological Process	GO:0042733	embryonic digit morphogenesis	NOG	IMP		Human	PMID:10080184
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	NOG	IMP		Human	PMID:16151340
Biological Process	GO:0048706	embryonic skeletal system development	NOG	IMP		Human	PMID:10080184
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nog3	IMP	ZFIN:ZDB-MRPHLNO-140711-2	Zfish	PMID:23410941
Biological Process	GO:0003203	endocardial cushion morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0007492	endoderm development	Nog	IDA		Mouse	PMID:24835669
Biological Process	GO:0001706	endoderm formation	Nog	IDA		Mouse	PMID:18462699
Biological Process	GO:0050673	epithelial cell proliferation	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:18028901
Biological Process	GO:0050673	epithelial cell proliferation	Nog	IGI	MGI:MGI:88180	Mouse	PMID:18028901
Biological Process	GO:0001837	epithelial to mesenchymal transition	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0035640	exploration behavior	Nog	IMP	MGI:MGI:2157350	Mouse	PMID:17634368
Biological Process	GO:0060325	face morphogenesis	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:12397106
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Nog	IGI	MGI:MGI:104327	Mouse	PMID:12397106
Biological Process	GO:0060825	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	NOG	IMP		Human	PMID:8582276
Biological Process	GO:0030900	forebrain development	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:10688202
Biological Process	GO:0030900	forebrain development	Nog	IGI	MGI:MGI:104327	Mouse	PMID:12397106
Biological Process	GO:0030900	forebrain development	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:12397106
Biological Process	GO:0030900	forebrain development	Nog	IEP		Rat	PMID:14643011|RGD:1358324
Biological Process	GO:0061384	heart trabecula morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0021766	hippocampus development	Nog	IEP		Rat	PMID:15171992|RGD:10416525
Biological Process	GO:0001701	in utero embryonic development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:17359964
Biological Process	GO:0060173	limb development	NOG	IMP		Human	PMID:10080184
Biological Process	GO:0060291	long-term synaptic potentiation	Nog	IMP	MGI:MGI:2157350	Mouse	PMID:17634368
Biological Process	GO:0060425	lung morphogenesis	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0003149	membranous septum morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0007613	memory	Nog	IMP		Rat	PMID:12740172|RGD:10423996
Biological Process	GO:0048762	mesenchymal cell differentiation	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:18028901
Biological Process	GO:0048762	mesenchymal cell differentiation	Nog	IMP		Rat	PMID:21238590|RGD:12801486
Biological Process	GO:0001707	mesoderm formation	Nog	IDA		Mouse	PMID:18462699
Biological Process	GO:0042474	middle ear morphogenesis	NOG	IMP		Human	PMID:10080184
Biological Process	GO:0008045	motor neuron axon guidance	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:12435358
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Nog	IMP		Mouse	MGI:MGI:3808973|PMID:18028109
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Nog	IMP		Rat	PMID:14975730|RGD:1358325
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	NOG	IDA		Human	PMID:10780858
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	NOG	IDA		Human	PMID:15539560
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	NOG	IDA		Human	PMID:8752214
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IDA		Mouse	MGI:MGI:3715084|PMID:17400546
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IDA		Mouse	PMID:17360443
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IDA		Mouse	PMID:15975920
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IGI	MGI:MGI:88182	Mouse	PMID:19852960
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IDA		Mouse	PMID:15110716
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IGI	MGI:MGI:88177	Mouse	PMID:19852960
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IDA		Mouse	PMID:19850029
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IDA		Mouse	PMID:18462699
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	nog3	IMP		Zfish	PMID:10491267
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	nog3	IMP		Zfish	PMID:9882485
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	nog1	IMP		Zfish	PMID:10491267
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	NOG	IDA		Human	PMID:15539560
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0061037	negative regulation of cartilage development	Nog	IDA		Mouse	PMID:10684250
Biological Process	GO:0030336	negative regulation of cell migration	NOG	IDA		Human	PMID:20675382
Biological Process	GO:0060302	negative regulation of cytokine activity	NOG	IDA		Human	PMID:8752214
Biological Process	GO:0042664	negative regulation of endodermal cell fate specification	nog1	IGI	ZFIN:ZDB-MRPHLNO-050714-1,ZFIN:ZDB-MRPHLNO-060328-4,ZFIN:ZDB-MRPHLNO-060731-3	Zfish	PMID:16672336
Biological Process	GO:1905006	negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0010629	negative regulation of gene expression	Nog	IDA		Mouse	PMID:21624478
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	NOG	IDA		Human	PMID:20675382
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	NOG	IDA		Human	PMID:15539560
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0001839	neural plate morphogenesis	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0001843	neural tube closure	Nog	IMP	MGI:MGI:1856173	Mouse	PMID:16712836
Biological Process	GO:0001843	neural tube closure	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0021915	neural tube development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:9585504
Biological Process	GO:0048570	notochord morphogenesis	Nog	IMP		Mouse	PMID:16916379
Biological Process	GO:0001503	ossification	Nog	IEP		Rat	PMID:24611347|RGD:10429074
Biological Process	GO:0001649	osteoblast differentiation	Nog	IMP		Mouse	MGI:MGI:3810620|PMID:10780858
Biological Process	GO:0003151	outflow tract morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0007389	pattern specification process	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:12397106
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0021983	pituitary gland development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:17359964
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Nog	IDA		Mouse	MGI:MGI:3714585|PMID:17522159
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	Nog	IDA		Mouse	MGI:MGI:2446986|PMID:12141440
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nog	IMP		Rat	PMID:15265600|RGD:10427780
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:18028901
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Nog	IGI	MGI:MGI:88180	Mouse	PMID:18028901
Biological Process	GO:0010628	positive regulation of gene expression	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0090193	positive regulation of glomerulus development	Nog	IDA		Mouse	MGI:MGI:2446986|PMID:12141440
Biological Process	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	Nog	IMP		Rat	PMID:14975730|RGD:1358325
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nog	IGI	MGI:MGI:98297	Mouse	PMID:9585504
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nog	IDA		Mouse	PMID:9585504
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Nog	IDA		Mouse	PMID:17634368
Biological Process	GO:0048793	pronephros development	nog3	IMP	ZFIN:ZDB-GENO-080731-3	Zfish	PMID:21596840
Biological Process	GO:0060513	prostatic bud formation	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:18028901
Biological Process	GO:0030510	regulation of BMP signaling pathway	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:17359964
Biological Process	GO:2000313	regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation	NOG	IMP		Human	PMID:8582276
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	Nog	IMP	MGI:MGI:2157350	Mouse	PMID:17634368
Biological Process	GO:1990926	short-term synaptic potentiation	Nog	IMP	MGI:MGI:2157350	Mouse	PMID:17634368
Biological Process	GO:0001501	skeletal system development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:11784076
Biological Process	GO:0007224	smoothened signaling pathway	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:12397106
Biological Process	GO:0007224	smoothened signaling pathway	Nog	IGI	MGI:MGI:104327	Mouse	PMID:12397106
Biological Process	GO:0035019	somatic stem cell population maintenance	NOG	IMP		Human	PMID:17889703
Biological Process	GO:0061053	somite development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0042305	specification of segmental identity, mandibular segment	Nog	IGI	MGI:MGI:1313268	Mouse	PMID:11784076
Biological Process	GO:0021510	spinal cord development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:16712836
Biological Process	GO:0048863	stem cell differentiation	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:18028901
Biological Process	GO:0001657	ureteric bud development	Nog	IDA		Mouse	PMID:12141440
Biological Process	GO:0060676	ureteric bud formation	Nog	IDA		Mouse	MGI:MGI:3714585|PMID:17522159
Biological Process	GO:0001655	urogenital system development	Nog	IMP	MGI:MGI:1862000	Mouse	PMID:18028901
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0060412	ventricular septum morphogenesis	Nog	IMP		Mouse	MGI:MGI:3783944|PMID:17218603
Biological Process	GO:0008542	visual learning	Nog	IMP	MGI:MGI:2157350	Mouse	PMID:17634368
Biological Process	GO:0008542	visual learning	Nog	IMP		Rat	PMID:12740172|RGD:10423996
Biological Process	GO:0042060	wound healing	Nog	IMP		Mouse	MGI:MGI:3808973|PMID:18028109
Biological Process	GO:0042060	wound healing	Nog	IEP		Rat	PMID:25754758|RGD:12879824

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern