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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nos1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nos1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0051117ATPase bindingNos1IPIUniProtKB:P23634RatPMID:11591728|RGD:10047158
Molecular FunctionGO:0046870cadmium ion bindingNos1IDARatPMID:17029414|RGD:1598372
Molecular FunctionGO:0048306calcium-dependent protein bindingNos1IPIUniProtKB:P23634RatPMID:23549614|RGD:14995314
Molecular FunctionGO:0005516calmodulin bindingNos1IDARatPMID:14966111|RGD:1358520
Molecular FunctionGO:0005516calmodulin bindingNos1IDARatPMID:20529840|RGD:7241266
Molecular FunctionGO:0019899enzyme bindingNos1IPIRGD:2151RatPMID:16537391|RGD:1582129
Molecular FunctionGO:0050660flavin adenine dinucleotide bindingNos1IDARatPMID:1383204|RGD:8553334
Molecular FunctionGO:0050660flavin adenine dinucleotide bindingNos1IDARatPMID:14966111|RGD:1358520
Molecular FunctionGO:0050660flavin adenine dinucleotide bindingNos1IDARatPMID:17029414|RGD:1598372
Molecular FunctionGO:0010181FMN bindingNos1IDARatPMID:1383204|RGD:8553334
Molecular FunctionGO:0010181FMN bindingNos1IDARatPMID:14966111|RGD:1358520
Molecular FunctionGO:0010181FMN bindingNos1IDARatPMID:17029414|RGD:1598372
Molecular FunctionGO:0020037heme bindingNos1IDARatPMID:1383204|RGD:8553334
Molecular FunctionGO:0042802identical protein bindingNos1IPIRGD:3184RatPMID:17347455|RGD:1642144
Molecular FunctionGO:0042802identical protein bindingNos1IPIRGD:3184RatPMID:23832698|RGD:7257598
Molecular FunctionGO:0050661NADP bindingNos1IDARatPMID:17029414|RGD:1598372
Molecular FunctionGO:0070402NADPH bindingNos1IDARatPMID:14966111|RGD:1358520
Molecular FunctionGO:0004517nitric-oxide synthase activityNOS1IDAHumanPMID:1689048
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDAMouseMGI:MGI:3807771|PMID:7545544
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDAMouseMGI:MGI:5582183|PMID:11591728
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDARatPMID:1383204|RGD:8553334
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDARatPMID:14966111|RGD:1358520
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDARatPMID:16387842|RGD:1580263
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDARatPMID:17029414|RGD:1598372
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDARatPMID:18591664|RGD:8554165
Molecular FunctionGO:0004517nitric-oxide synthase activityNos1IDARatPMID:23549614|RGD:14995314
Molecular FunctionGO:0051219phosphoprotein bindingNos1IPIUniProtKB:Q9Z2F5RatPMID:11590170|RGD:12793005
Molecular FunctionGO:0005515protein bindingNOS1IPIUniProtKB:Q9Y314HumanPMID:11149895
Molecular FunctionGO:0005515protein bindingNOS1IPIUniProtKB:Q08AM6HumanPMID:17161399
Molecular FunctionGO:0005515protein bindingNOS1IPIUniProtKB:P11532HumanPMID:27225184
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:P23634MouseMGI:MGI:3771112|PMID:17242280
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:Q05769MouseMGI:MGI:3807118|PMID:18650379
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:P11531MouseMGI:MGI:3807771|PMID:7545544
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:Q60857MouseMGI:MGI:3710710|PMID:17452640
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:Q9D3A8MouseMGI:MGI:5613473|PMID:19800018
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:O54960RatPMID:11086993|RGD:633891
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:P62157RatPMID:11284722|RGD:8553336
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:O54960RatPMID:11867766|RGD:8553593
Molecular FunctionGO:0005515protein bindingNos1IPIRGD:619866RatPMID:15384421|RGD:13207431
Molecular FunctionGO:0005515protein bindingNos1IPIRGD:2151RatPMID:16537391|RGD:1582129
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:O08701RatPMID:16537391|RGD:1582129
Molecular FunctionGO:0005515protein bindingNos1IPIRGD:620106RatPMID:20202870|RGD:5131967
Molecular FunctionGO:0005515protein bindingNos1IPIRGD:71096|RGD:2513|RGD:727949RatPMID:21490139|RGD:5131889
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:P62157RatPMID:22004458|RGD:8554287
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:P23634RatPMID:23549614|RGD:14995314
Molecular FunctionGO:0005515protein bindingNos1IPIUniProtKB:O54960RatPMID:9459447|RGD:632364
Molecular FunctionGO:0097110scaffold protein bindingNos1IPIUniProtKB:Q13424RatPMID:18591664|RGD:8554165
Molecular FunctionGO:0017080sodium channel regulator activityNos1IMPRatPMID:18591664|RGD:8554165
Molecular FunctionGO:0044325transmembrane transporter bindingNos1IPIUniProtKB:Q14524RatPMID:18591664|RGD:8554165
Molecular FunctionGO:0008270zinc ion bindingNos1IDARatPMID:10954720|RGD:13824990
Cellular ComponentGO:0042582azurophil granuleNos1IDARatPMID:16387842|RGD:1580263
Cellular ComponentGO:0044305calyx of HeldNos1IMPMousePMID:19038221
Cellular ComponentGO:0044305calyx of HeldNos1IDAMousePMID:19038221
Cellular ComponentGO:0005901caveolaNos1IDAMouseMGI:MGI:5613473|PMID:19800018
Cellular ComponentGO:0071944cell peripheryNos1IDARatPMID:23549614|RGD:14995314
Cellular ComponentGO:0005737cytoplasmNos1IDARatPMID:11590170|RGD:12793005
Cellular ComponentGO:0005737cytoplasmNos1IDARatPMID:12526033|RGD:727494
Cellular ComponentGO:0005737cytoplasmNos1IDARatPMID:16387842|RGD:1580263
Cellular ComponentGO:0005737cytoplasmNos1IDARatPMID:23549614|RGD:14995314
Cellular ComponentGO:0005856cytoskeletonNos1IDAMouseMGI:MGI:3807771|PMID:7545544
Cellular ComponentGO:0005829cytosolNos1IDARatPMID:16361261|RGD:1598374
Cellular ComponentGO:0030425dendriteNos1IDARatPMID:12526033|RGD:727494
Cellular ComponentGO:0098978glutamatergic synapseNos1IDARatPMID:12388603|RGD:12050093
Cellular ComponentGO:0016020membraneNos1IDARatPMID:21490139|RGD:5131889
Cellular ComponentGO:0045121membrane raftNos1IDAMousePMID:10037495
Cellular ComponentGO:0005741mitochondrial outer membraneNos1IDARatPMID:12526033|RGD:727494
Cellular ComponentGO:0005739mitochondrionNos1IDAMouseMGI:MGI:5613473|PMID:19800018
Cellular ComponentGO:0005739mitochondrionNos1IDARatPMID:16361261|RGD:1598374
Cellular ComponentGO:0005739mitochondrionNos1IDARatPMID:16537391|RGD:1582129
Cellular ComponentGO:0031965nuclear membraneNos1IDARatPMID:16387842|RGD:1580263
Cellular ComponentGO:0005654nucleoplasmNOS1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusNos1IDARatPMID:11590170|RGD:12793005
Cellular ComponentGO:0005634nucleusNos1IDARatPMID:16387842|RGD:1580263
Cellular ComponentGO:0048471perinuclear region of cytoplasmNos1IDARatPMID:17027776|RGD:8554510
Cellular ComponentGO:0001917photoreceptor inner segmentNos1IDARatPMID:17027776|RGD:8554510
Cellular ComponentGO:0005886plasma membraneNOS1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005886plasma membraneNos1IDARatPMID:16387842|RGD:1580263
Cellular ComponentGO:0014069postsynaptic densityNos1IDARatPMID:11226670|RGD:5147998
Cellular ComponentGO:0014069postsynaptic densityNos1IDARatPMID:12388603|RGD:12050093
Cellular ComponentGO:0099092postsynaptic density, intracellular componentNos1IDARatPMID:12388603|RGD:12050093
Cellular ComponentGO:0099091postsynaptic specialization, intracellular componentNos1IDARatPMID:12388603|RGD:12050093
Cellular ComponentGO:0032991protein-containing complexNos1IDARatPMID:18591664|RGD:8554165
Cellular ComponentGO:0042383sarcolemmaNOS1IDAHumanPMID:27225184
Cellular ComponentGO:0042383sarcolemmaNOS1IDAHumanPMID:7545544
Cellular ComponentGO:0042383sarcolemmaNos1IDAMouseMGI:MGI:3807771|PMID:7545544
Cellular ComponentGO:0042383sarcolemmaNos1IDARatPMID:7527495|RGD:8554202
Cellular ComponentGO:0016529sarcoplasmic reticulumNOS1IDAHumanPMID:9892689
Cellular ComponentGO:0033017sarcoplasmic reticulum membraneNos1IDAMouseMGI:MGI:5613473|PMID:19800018
Cellular ComponentGO:0030141secretory granuleNos1IDARatPMID:11375331|RGD:13825134
Cellular ComponentGO:0045202synapseNos1IDAMousePMID:10995443
Cellular ComponentGO:0045202synapseNos1IDARatPMID:12526033|RGD:727494
Cellular ComponentGO:0030315T-tubuleNos1IDAMouseMGI:MGI:5613473|PMID:19800018
Cellular ComponentGO:0012506vesicle membraneNos1IDARatPMID:21448354|RGD:5131895
Cellular ComponentGO:0030018Z discNos1IDAMouseMGI:MGI:5613473|PMID:19800018
Biological ProcessGO:0007568agingNos1IEPRatPMID:17683464|RGD:1642135
Biological ProcessGO:0006527arginine catabolic processNos1IDARatPMID:1383204|RGD:8553334
Biological ProcessGO:0048148behavioral response to cocaineNos1IMPRatPMID:23579428|RGD:7257653
Biological ProcessGO:0007420brain developmentNos1IEPRatPMID:12727317|RGD:13824994
Biological ProcessGO:0006816calcium ion transportNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0071872cellular response to epinephrine stimulusNos1IMPRatPMID:19278978|RGD:10047220
Biological ProcessGO:0071363cellular response to growth factor stimulusNos1IMPMouseMGI:MGI:4839449|PMID:16427017
Biological ProcessGO:0071260cellular response to mechanical stimulusNos1IMPRatPMID:23619128|RGD:7257608
Biological ProcessGO:0048668collateral sproutingnos1IMPZFIN:ZDB-MRPHLNO-100503-12ZfishPMID:21159953
Biological ProcessGO:0051649establishment of localization in cellNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0045184establishment of protein localizationNos1IDARatPMID:11590170|RGD:12793005
Biological ProcessGO:0007565female pregnancyNos1IEPRatPMID:20630934|RGD:5131941
Biological ProcessGO:0007565female pregnancyNos1IEPRatPMID:23283939|RGD:7257666
Biological ProcessGO:0060218hematopoietic stem cell differentiationnos1IMPZFIN:ZDB-MRPHLNO-100503-13ZfishPMID:19450519
Biological ProcessGO:0060218hematopoietic stem cell differentiationnos1IMPZFIN:ZDB-MRPHLNO-100503-12ZfishPMID:19450519
Biological ProcessGO:0001889liver developmentnos1IMPZFIN:ZDB-MRPHLNO-100503-12ZfishPMID:24388745
Biological ProcessGO:0033555multicellular organismal response to stressNOS1IMPHumanPMID:18391107
Biological ProcessGO:0043066negative regulation of apoptotic processNos1IMPRatPMID:20596694|RGD:5131956
Biological ProcessGO:0045776negative regulation of blood pressureNos1IMPRatPMID:15331368|RGD:1598375
Biological ProcessGO:0051926negative regulation of calcium ion transportNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0008285negative regulation of cell population proliferationNos1IMPRatPMID:20338922|RGD:5131958
Biological ProcessGO:0051481negative regulation of cytosolic calcium ion concentrationNos1IMPRatPMID:23172925|RGD:7257670
Biological ProcessGO:0045822negative regulation of heart contractionNos1IMPRatPMID:15331368|RGD:1598375
Biological ProcessGO:0061875negative regulation of hepatic stellate cell contractionNos1IDARatPMID:10727442|RGD:13824993
Biological ProcessGO:0051346negative regulation of hydrolase activityNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0046676negative regulation of insulin secretionNos1IMPRatPMID:17130471|RGD:1642149
Biological ProcessGO:0034760negative regulation of iron ion transmembrane transportNos1IMPRatPMID:14752097|RGD:13824992
Biological ProcessGO:0043524negative regulation of neuron apoptotic processNos1IMPRatPMID:14752097|RGD:13824992
Biological ProcessGO:0033137negative regulation of peptidyl-serine phosphorylationNos1IMPRatPMID:19278978|RGD:10047220
Biological ProcessGO:0043267negative regulation of potassium ion transportNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0051612negative regulation of serotonin uptakeNos1IDAMouseMGI:MGI:3710710|PMID:17452640
Biological ProcessGO:0045906negative regulation of vasoconstrictionNos1IMPRatPMID:23640592|RGD:7257607
Biological ProcessGO:0006809nitric oxide biosynthetic processNos1IDAMouseMGI:MGI:5582183|PMID:11591728
Biological ProcessGO:0006809nitric oxide biosynthetic processNos1IDAMouseMGI:MGI:3807771|PMID:7545544
Biological ProcessGO:0006809nitric oxide biosynthetic processNos1IDARatPMID:1383204|RGD:8553334
Biological ProcessGO:0006809nitric oxide biosynthetic processNos1IDARatPMID:14966111|RGD:1358520
Biological ProcessGO:0007263nitric oxide mediated signal transductionNos1IMPRatPMID:19278978|RGD:10047220
Biological ProcessGO:0007263nitric oxide mediated signal transductionnos1IMPZFIN:ZDB-GENO-190218-5ZfishPMID:28951000
Biological ProcessGO:0007263nitric oxide mediated signal transductionnos1IMPZFIN:ZDB-MRPHLNO-100503-12ZfishPMID:19450519
Biological ProcessGO:0018119peptidyl-cysteine S-nitrosylationNos1IDAMousePMID:17293453
Biological ProcessGO:0018119peptidyl-cysteine S-nitrosylationNos1IDARatPMID:18591664|RGD:8554165
Biological ProcessGO:0140196positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart processNos1IMPMouseMGI:MGI:3771112|PMID:17242280
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionNos1IMPMouseMGI:MGI:4839449|PMID:16427017
Biological ProcessGO:0035066positive regulation of histone acetylationNos1IMPMouseMGI:MGI:4839449|PMID:16427017
Biological ProcessGO:1900273positive regulation of long-term synaptic potentiationNos1IMPRatPMID:23579428|RGD:7257653
Biological ProcessGO:1901216positive regulation of neuron deathNos1IMPRatPMID:23062100|RGD:7257671
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationNOS1IMPHumanPMID:28089352
Biological ProcessGO:1902307positive regulation of sodium ion transmembrane transportNos1IMPRatPMID:18591664|RGD:8554165
Biological ProcessGO:0098735positive regulation of the force of heart contractionNos1IMPMouseMGI:MGI:3771112|PMID:17242280
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINos1IMPMGI:MGI:1857227MousePMID:12834919
Biological ProcessGO:0006813potassium ion transportNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0008016regulation of heart contractionNos1IMPRatPMID:16537391|RGD:1582129
Biological ProcessGO:0050767regulation of neurogenesisNos1IDAMouseMGI:MGI:5619742|PMID:21960957
Biological ProcessGO:0060078regulation of postsynaptic membrane potentialNos1IMPMousePMID:19038221
Biological ProcessGO:0060078regulation of postsynaptic membrane potentialNos1IDAMousePMID:19038221
Biological ProcessGO:0051930regulation of sensory perception of painNos1IMPRatPMID:17101217|RGD:1642150
Biological ProcessGO:0002028regulation of sodium ion transportNos1IMPMGI:MGI:1857227MousePMID:12074580
Biological ProcessGO:0014823response to activityNos1IEPRatPMID:19793134|RGD:5132589
Biological ProcessGO:0043627response to estrogenNos1IDARatPMID:17553983|RGD:1642139
Biological ProcessGO:0045471response to ethanolNos1IEPRatPMID:12581836|RGD:13824996
Biological ProcessGO:0045471response to ethanolNos1IEPRatPMID:16737454|RGD:1598373
Biological ProcessGO:0009408response to heatNOS1IDAHumanPMID:18048451
Biological ProcessGO:0009408response to heatNos1IEPRatPMID:16950411|RGD:1642129
Biological ProcessGO:0001666response to hypoxiaNOS1IEPHumanPMID:16276418
Biological ProcessGO:0001666response to hypoxiaNos1IEPRatPMID:16276418|RGD:8553323
Biological ProcessGO:0001666response to hypoxiaNos1IEPRatPMID:17442632|RGD:1642143
Biological ProcessGO:0010288response to lead ionNos1IEPRatPMID:19524414|RGD:5132593
Biological ProcessGO:0032496response to lipopolysaccharideNos1IEPRatPMID:20724006|RGD:5131926
Biological ProcessGO:0035094response to nicotineNos1IEPRatPMID:21050840|RGD:5131913
Biological ProcessGO:0071731response to nitric oxideNos1IEPRatPMID:20473255|RGD:5131957
Biological ProcessGO:0031667response to nutrient levelsNos1IEPRatPMID:20079408|RGD:5131982
Biological ProcessGO:0014070response to organic cyclic compoundNos1IEPRatPMID:17611313|RGD:1642137
Biological ProcessGO:0010243response to organonitrogen compoundNos1IEPRatPMID:17310378|RGD:1642145
Biological ProcessGO:0043434response to peptide hormoneNos1IMPRatPMID:20181617|RGD:5131977
Biological ProcessGO:0033197response to vitamin ENos1IEPRatPMID:17200156|RGD:1642147
Biological ProcessGO:0098924retrograde trans-synaptic signaling by nitric oxideNos1IMPMouseMGI:MGI:5140220|PMID:21813683
Biological ProcessGO:0007210serotonin receptor signaling pathwaynos1IMPZFIN:ZDB-GENO-190218-5ZfishPMID:28951000
Biological ProcessGO:0006941striated muscle contractionNos1IMPMGI:MGI:1857227MousePMID:16537391
Biological ProcessGO:0099163synaptic signaling by nitric oxideNos1IMPMousePMID:19038221
Biological ProcessGO:0099163synaptic signaling by nitric oxideNos1IDAMousePMID:19038221
Biological ProcessGO:0042311vasodilationNOS1IDAHumanPMID:18048451
Biological ProcessGO:0042311vasodilationNOS1IMPHumanPMID:18391107
Biological ProcessGO:0042311vasodilationNos1IMPRatPMID:17291465|RGD:1642146
Biological ProcessGO:0021517ventral spinal cord developmentnos1IMPZFIN:ZDB-MRPHLNO-100503-12ZfishPMID:21159953
Biological ProcessGO:0042178xenobiotic catabolic processNos1IMPMGI:MGI:1857227MousePMID:11158245

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory