Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOS2
  • Mouse genes Nos2
  • Rat genes Nos2
  • Zfish genes nos2a,nos2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nos2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	Nos2	IDA		Rat	PMID:15858215|RGD:7777144
Molecular Function	GO:0034618	arginine binding	Nos2	IDA		Mouse	MGI:MGI:3807769|PMID:9271491
Molecular Function	GO:0008013	beta-catenin binding	Nos2	IPI	RGD:70487	Rat	PMID:15858215|RGD:7777144
Molecular Function	GO:0045296	cadherin binding	Nos2	IPI	RGD:69280	Rat	PMID:15858215|RGD:7777144
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	Nos2	IDA		Rat	PMID:12107056|RGD:625635
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	Nos2	IDA		Mouse	MGI:MGI:3807772|PMID:1383204
Molecular Function	GO:0010181	FMN binding	Nos2	IDA		Mouse	MGI:MGI:3807772|PMID:1383204
Molecular Function	GO:0020037	heme binding	Nos2	IDA		Mouse	MGI:MGI:3807772|PMID:1383204
Molecular Function	GO:0020037	heme binding	Nos2	IDA		Mouse	MGI:MGI:3807769|PMID:9271491
Molecular Function	GO:0051879	Hsp90 protein binding	Nos2	IDA		Rat	PMID:15475520|RGD:5132625
Molecular Function	GO:0042802	identical protein binding	Nos2	IPI	RGD:3185	Rat	PMID:16172396|RGD:1580262
Molecular Function	GO:0004517	nitric-oxide synthase activity	NOS2	IDA		Human	PMID:7504305
Molecular Function	GO:0004517	nitric-oxide synthase activity	NOS2	IDA		Human	PMID:7682706
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos2	IDA		Mouse	MGI:MGI:3807769|PMID:9271491
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos2	IDA		Mouse	MGI:MGI:3807772|PMID:1383204
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos2	IDA		Rat	PMID:11788371|RGD:70247
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos2	IDA		Rat	PMID:16172396|RGD:1580262
Molecular Function	GO:0050998	nitric-oxide synthase binding	Nos2	IPI	RGD:3186	Rat	PMID:15858215|RGD:7777144
Molecular Function	GO:0005515	protein binding	NOS2	IPI	UniProtKB:P07901	Human	PMID:12855682
Molecular Function	GO:0005515	protein binding	NOS2	IPI	UniProtKB:Q96A44	Human	PMID:21199876
Molecular Function	GO:0005515	protein binding	NOS2	IPI	UniProtKB:Q96BD6	Human	PMID:21199876
Molecular Function	GO:0005515	protein binding	NOS2	IPI	UniProtKB:Q99619	Human	PMID:21199876
Molecular Function	GO:0005515	protein binding	NOS2	IPI	UniProtKB:P04406	Human	PMID:25417112
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:4949802|PMID:21464294
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:Q76LV2	Mouse	MGI:MGI:3687888|PMID:12855682
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:P07900	Mouse	MGI:MGI:3687888|PMID:12855682
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:O88838|UniProtKB:Q8R5B6|UniProtKB:Q9D5L7	Mouse	MGI:MGI:4820465|PMID:20603330
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:P04441	Mouse	MGI:MGI:4943392|PMID:18003616
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:P35354	Mouse	MGI:MGI:4887336|PMID:16373578
Molecular Function	GO:0005515	protein binding	Nos2	IPI	PR:P57780	Mouse	PMID:12960352
Molecular Function	GO:0005515	protein binding	Nos2	IPI	UniProtKB:Q7TQN4	Rat	PMID:21464294|RGD:13432331
Molecular Function	GO:0042803	protein homodimerization activity	Nos2	IDA		Mouse	MGI:MGI:3807769|PMID:9271491
Molecular Function	GO:0019901	protein kinase binding	Nos2	IPI	RGD:2263	Rat	PMID:17293490|RGD:7240712
Molecular Function	GO:0034617	tetrahydrobiopterin binding	Nos2	IDA		Mouse	MGI:MGI:3807769|PMID:9271491
Cellular Component	GO:0030863	cortical cytoskeleton	Nos2	IDA		Mouse	PMID:12960352
Cellular Component	GO:0005737	cytoplasm	NOS2	IDA		Human	PMID:12085352
Cellular Component	GO:0005737	cytoplasm	NOS2	IDA		Human	PMID:9916929
Cellular Component	GO:0005737	cytoplasm	Nos2	IDA		Mouse	PMID:12960352
Cellular Component	GO:0005737	cytoplasm	Nos2	IDA		Mouse	PMID:11732991
Cellular Component	GO:0005737	cytoplasm	Nos2	IDA		Rat	PMID:11943139|RGD:8554470
Cellular Component	GO:0005737	cytoplasm	Nos2	IDA		Rat	PMID:12085352|RGD:8656007
Cellular Component	GO:0005737	cytoplasm	Nos2	IDA		Rat	PMID:16387842|RGD:1580263
Cellular Component	GO:0005829	cytosol	NOS2	IMP		Human	PMID:7504305
Cellular Component	GO:0005829	cytosol	Nos2	IDA		Rat	PMID:12085352|RGD:8656007
Cellular Component	GO:0005615	extracellular space	Nos2	IDA		Rat	PMID:22019508|RGD:5509038
Cellular Component	GO:0005634	nucleus	Nos2	IDA		Rat	PMID:11943139|RGD:8554470
Cellular Component	GO:0005634	nucleus	Nos2	IDA		Rat	PMID:16387842|RGD:1580263
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nos2	IDA		Mouse	PMID:12960352
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nos2	IDA		Rat	PMID:17293490|RGD:7240712
Cellular Component	GO:0005777	peroxisome	NOS2	IDA		Human	PMID:12085352
Cellular Component	GO:0005777	peroxisome	Nos2	IDA		Rat	PMID:12085352|RGD:8656007
Cellular Component	GO:0005777	peroxisome	Nos2	IDA		Rat	PMID:16172396|RGD:1580262
Cellular Component	GO:0012506	vesicle membrane	Nos2	IDA		Rat	PMID:21448354|RGD:5131895
Biological Process	GO:0007568	aging	Nos2	IEP		Rat	PMID:19543853|RGD:2313213
Biological Process	GO:0006527	arginine catabolic process	NOS2	IDA		Human	PMID:7504305
Biological Process	GO:0006527	arginine catabolic process	Nos2	IDA		Mouse	MGI:MGI:3807772|PMID:1383204
Biological Process	GO:0001974	blood vessel remodeling	Nos2	IMP		Rat	PMID:15800493|RGD:1580261
Biological Process	GO:0071345	cellular response to cytokine stimulus	Nos2	IDA		Rat	PMID:19414010|RGD:10402041
Biological Process	GO:0071347	cellular response to interleukin-1	Nos2	IEP		Rat	PMID:22001142|RGD:5508716
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Nos2	IDA		Mouse	PMID:18025219
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Nos2	IDA		Mouse	PMID:18791161
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Nos2	IEP		Rat	PMID:21975807|RGD:5508737
Biological Process	GO:0071285	cellular response to lithium ion	Nos2	IEP		Rat	PMID:21994254|RGD:5508722
Biological Process	GO:0071407	cellular response to organic cyclic compound	Nos2	IDA		Rat	PMID:19414010|RGD:10402041
Biological Process	GO:0071461	cellular response to redox state	Nos2	IEP		Rat	PMID:21964032|RGD:5508744
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Nos2	IEP		Rat	PMID:21965676|RGD:5508742
Biological Process	GO:0071346	cellular response to type II interferon	Nos2	IDA		Mouse	PMID:18025219
Biological Process	GO:0071305	cellular response to vitamin D	Nos2	IEP		Rat	PMID:18534083|RGD:4891908
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Nos2	IDA		Mouse	PMID:24486487
Biological Process	GO:0019934	cGMP-mediated signaling	Nos2	IDA		Rat	PMID:12107056|RGD:625635
Biological Process	GO:0007623	circadian rhythm	Nos2	IEP		Mouse	MGI:MGI:5308514|PMID:22073225
Biological Process	GO:0042742	defense response to bacterium	NOS2	IMP		Human	PMID:9284131
Biological Process	GO:0042742	defense response to bacterium	Nos2	IMP	MGI:MGI:1857228	Mouse	PMID:12933833
Biological Process	GO:0050829	defense response to Gram-negative bacterium	Nos2	IEP		Rat	PMID:16865779|RGD:1582113
Biological Process	GO:0001935	endothelial cell proliferation	Nos2	IEP		Rat	PMID:15800493|RGD:1580261
Biological Process	GO:0007199	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	Nos2	IDA		Rat	PMID:12107056|RGD:625635
Biological Process	GO:0016137	glycoside metabolic process	Nos2	IEP		Rat	PMID:22006678|RGD:5508715
Biological Process	GO:0090594	inflammatory response to wounding	nos2b	IMP	ZFIN:ZDB-MRPHLNO-160120-1	Zfish	PMID:26444552
Biological Process	GO:0035556	intracellular signal transduction	Nos2	IMP		Rat	PMID:15001568|RGD:1580266
Biological Process	GO:0010629	negative regulation of gene expression	NOS2	IGI	UniProtKB:P29477	Human	PMID:12085352
Biological Process	GO:0010629	negative regulation of gene expression	Nos2	IGI	UniProtKB:P35228	Mouse	MGI:MGI:5319619|PMID:12085352
Biological Process	GO:0042177	negative regulation of protein catabolic process	Nos2	IDA		Mouse	MGI:MGI:4943392|PMID:18003616
Biological Process	GO:0006809	nitric oxide biosynthetic process	NOS2	IDA		Human	PMID:7504305
Biological Process	GO:0006809	nitric oxide biosynthetic process	NOS2	IDA		Human	PMID:7682706
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos2	IDA		Mouse	MGI:MGI:3807769|PMID:9271491
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos2	IDA		Mouse	MGI:MGI:3807772|PMID:1383204
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos2	IDA		Rat	PMID:12826065|RGD:1358527
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos2	IDA		Rat	PMID:16172396|RGD:1580262
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	Nos2	IDA		Mouse	MGI:MGI:4887336|PMID:16373578
Biological Process	GO:0043065	positive regulation of apoptotic process	Nos2	IMP		Rat	PMID:12208351|RGD:4891948
Biological Process	GO:0032755	positive regulation of interleukin-6 production	NOS2	IDA		Human	PMID:19688109
Biological Process	GO:0032757	positive regulation of interleukin-8 production	NOS2	IDA		Human	PMID:19688109
Biological Process	GO:0051712	positive regulation of killing of cells of another organism	NOS2	IMP		Human	PMID:7544003
Biological Process	GO:0032310	prostaglandin secretion	NOS2	IDA		Human	PMID:19688109
Biological Process	GO:0008217	regulation of blood pressure	Nos2	IMP		Rat	PMID:12959638|RGD:1580267
Biological Process	GO:0008217	regulation of blood pressure	Nos2	IMP		Rat	PMID:16650388|RGD:1582114
Biological Process	GO:0042127	regulation of cell population proliferation	Nos2	IGI	MGI:MGI:88039	Mouse	PMID:11731407
Biological Process	GO:0042127	regulation of cell population proliferation	Nos2	IGI	MGI:MGI:88039	Mouse	PMID:11606502
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	NOS2	IDA		Human	PMID:19688109
Biological Process	GO:0008016	regulation of heart contraction	Nos2	IMP		Rat	PMID:16650388|RGD:1582114
Biological Process	GO:0050796	regulation of insulin secretion	NOS2	IMP		Human	PMID:8383325
Biological Process	GO:0014823	response to activity	Nos2	IEP		Rat	PMID:12009427|RGD:625574
Biological Process	GO:0009617	response to bacterium	Nos2	IEP		Mouse	PMID:23012479
Biological Process	GO:0071548	response to dexamethasone	Nos2	IEP		Rat	PMID:21986892|RGD:5508723
Biological Process	GO:0032355	response to estradiol	Nos2	IEP		Rat	PMID:17919391|RGD:4891405
Biological Process	GO:0009750	response to fructose	Nos2	IEP		Rat	PMID:10997722|RGD:152176656
Biological Process	GO:0009749	response to glucose	Nos2	IEP		Rat	PMID:9001735|RGD:152176654
Biological Process	GO:0009749	response to glucose	nos2a	IDA		Zfish	PMID:26276677
Biological Process	GO:0009725	response to hormone	Nos2	IEP		Rat	PMID:21107779|RGD:4891169
Biological Process	GO:0001666	response to hypoxia	Nos2	IDA		Mouse	PMID:12960352
Biological Process	GO:0035902	response to immobilization stress	Nos2	IEP		Rat	PMID:21986672|RGD:5508724
Biological Process	GO:0032496	response to lipopolysaccharide	Nos2	IDA		Mouse	MGI:MGI:5308514|PMID:22073225
Biological Process	GO:0032496	response to lipopolysaccharide	Nos2	IEP		Rat	PMID:9686345|RGD:4139908
Biological Process	GO:0032496	response to lipopolysaccharide	nos2a	IDA		Zfish	PMID:19501636
Biological Process	GO:0032496	response to lipopolysaccharide	nos2b	IDA		Zfish	PMID:19501636
Biological Process	GO:0009612	response to mechanical stimulus	Nos2	IEP		Rat	PMID:19329460|RGD:4891378
Biological Process	GO:0090649	response to oxygen-glucose deprivation	Nos2	IEP		Rat	PMID:10997722|RGD:152176656
Biological Process	GO:0034612	response to tumor necrosis factor	Nos2	IMP		Rat	PMID:19802525|RGD:4891376
Biological Process	GO:0009611	response to wounding	nos2a	IDA		Zfish	PMID:19501636
Biological Process	GO:0009611	response to wounding	nos2b	IDA		Zfish	PMID:19501636
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Nos2	IEP		Rat	PMID:15602748|RGD:1582142
Biological Process	GO:0007165	signal transduction	Nos2	IDA		Rat	PMID:12107056|RGD:625635
Biological Process	GO:0006801	superoxide metabolic process	Nos2	IMP	MGI:MGI:1857228	Mouse	PMID:12933833
Biological Process	GO:0036269	swimming behavior	nos2b	IMP	ZFIN:ZDB-GENO-221201-1	Zfish	PMID:33200539
Biological Process	GO:0042060	wound healing	Nos2	IEP		Rat	PMID:20973902|RGD:8693621

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern