Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Notch2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NOTCH2
- Mouse genes Notch2
- Rat genes Notch2
- Zfish genes notch2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Notch2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Notch2	IPI	UniProtKB:Q9NWT6	Mouse	MGI:MGI:5318027\|PMID:17573339
Molecular Function	GO:0051059	NF-kappaB binding	Notch2	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:3814108\|PMID:18710934
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:O00548	Human	PMID:10079256
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:Q92585	Human	PMID:11101851
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:O00548	Human	PMID:11823422
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:P21741	Human	PMID:18469519
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:Q9NR00	Human	PMID:25985737
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:P62877,UniProtKB:P63208,UniProtKB:Q13616,UniProtKB:Q969H0	Human	PMID:29149593
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:Q9UPX6	Human	PMID:29329397
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:P0DPK3	Human	PMID:29856954
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:P0DPK4	Human	PMID:29856954
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:Q7Z3S9	Human	PMID:29856954
Molecular Function	GO:0005515	protein binding	NOTCH2	IPI	UniProtKB:P59773	Human	PMID:32954300
Molecular Function	GO:0005515	protein binding	Notch2	IPI	UniProtKB:Q9QXX0	Mouse	MGI:MGI:1347427\|PMID:10551863
Molecular Function	GO:0005515	protein binding	Notch2	IPI	UniProtKB:Q61483\|UniProtKB:Q9QYE5	Mouse	MGI:MGI:3691907\|PMID:12496659
Molecular Function	GO:0005515	protein binding	Notch2	IPI	UniProtKB:Q61483\|UniProtKB:Q9QXX0\|UniProtKB:Q9QYE5	Mouse	MGI:MGI:3029032\|PMID:10958687
Molecular Function	GO:0005515	protein binding	Notch2	IPI	PR:000049940	Mouse	PMID:34635817
Molecular Function	GO:0005515	protein binding	Notch2	IPI	PR:P31266	Mouse	PMID:9111338
Molecular Function	GO:0005515	protein binding	Notch2	IPI	PR:Q8R516	Mouse	PMID:34635817
Molecular Function	GO:0005515	protein binding	Notch2	IPI	PR:A2AFI6	Mouse	PMID:34635817
Molecular Function	GO:0005515	protein binding	Notch2	IPI	PR:O88516	Mouse	PMID:34635817
Cellular Component	GO:0009986	cell surface	NOTCH2	IDA		Human	PMID:9244302
Cellular Component	GO:0005929	cilium	Notch2	IDA		Mouse	PMID:21703454
Cellular Component	GO:0016020	membrane	NOTCH2	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	NOTCH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NOTCH2	IDA		Human	PMID:1303260
Cellular Component	GO:0005634	nucleus	Notch2	IDA		Mouse	MGI:MGI:3691907\|PMID:12496659
Cellular Component	GO:0005886	plasma membrane	NOTCH2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	NOTCH2	IDA		Human	PMID:29329397
Cellular Component	GO:0005886	plasma membrane	NOTCH2	IDA		Human	PMID:9244302
Cellular Component	GO:0005886	plasma membrane	Notch2	IDA		Mouse	PMID:34635817
Cellular Component	GO:0043235	receptor complex	NOTCH2	IDA		Human	PMID:23382219
Biological Process	GO:0032148	activation of protein kinase B activity	Notch2	IDA		Mouse	PMID:34635817
Biological Process	GO:0009887	animal organ morphogenesis	NOTCH2	IEP		Human	PMID:12531696
Biological Process	GO:0060413	atrial septum morphogenesis	NOTCH2	IMP		Human	PMID:16773578
Biological Process	GO:0030509	BMP signaling pathway	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23676271
Biological Process	GO:0046849	bone remodeling	NOTCH2	IMP		Human	PMID:21378985
Biological Process	GO:0046849	bone remodeling	NOTCH2	IMP		Human	PMID:21378989
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	notch2	IGI	ZFIN:ZDB-GENO-980202-1068,ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:20431122
Biological Process	GO:0001709	cell fate determination	Notch2	IDA		Rat	PMID:1295745\|RGD:69906
Biological Process	GO:0008283	cell population proliferation	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23676271
Biological Process	GO:0071228	cellular response to tumor cell	NOTCH2	IDA		Human	PMID:11306509
Biological Process	GO:1990705	cholangiocyte proliferation	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0061073	ciliary body morphogenesis	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23676271
Biological Process	GO:0042742	defense response to bacterium	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23913046
Biological Process	GO:0007368	determination of left/right symmetry	Notch2	IMP	MGI:MGI:1933205	Mouse	PMID:12730124
Biological Process	GO:0030326	embryonic limb morphogenesis	Notch2	IGI	MGI:MGI:97363	Mouse	PMID:16169548
Biological Process	GO:0031018	endocrine pancreas development	notch2	IMP	ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:26963759
Biological Process	GO:0060325	face morphogenesis	notch2	IGI	ZFIN:ZDB-GENO-980202-1068,ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:20431122
Biological Process	GO:0072104	glomerular capillary formation	Notch2	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0042593	glucose homeostasis	notch2	IMP	ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:26963759
Biological Process	GO:0001947	heart looping	Notch2	IGI	UniProtKB:Q01705	Mouse	MGI:MGI:2661305\|PMID:12730124
Biological Process	GO:0072574	hepatocyte proliferation	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0006959	humoral immune response	Notch2	IGI	MGI:MGI:97363	Mouse	PMID:17658279
Biological Process	GO:0001701	in utero embryonic development	Notch2	IMP	MGI:MGI:1857783	Mouse	PMID:17359302
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Notch2	IGI	MGI:MGI:97363	Mouse	PMID:17658279
Biological Process	GO:0032633	interleukin-4 production	Notch2	IGI	MGI:MGI:97363	Mouse	PMID:17658279
Biological Process	GO:0035622	intrahepatic bile duct development	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0070986	left/right axis specification	Notch2	IGI	UniProtKB:Q01705	Mouse	MGI:MGI:2661305\|PMID:12730124
Biological Process	GO:0001889	liver development	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0001889	liver development	notch2	IGI	ZFIN:ZDB-GENE-000329-5	Zfish	PMID:15509774
Biological Process	GO:0001889	liver development	notch2	IGI	ZFIN:ZDB-GENE-011128-3	Zfish	PMID:15509774
Biological Process	GO:0072576	liver morphogenesis	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0001946	lymphangiogenesis	notch2	IMP	ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:20466977
Biological Process	GO:0002315	marginal zone B cell differentiation	Notch2	IMP		Mouse	MGI:MGI:3838059\|PMID:19217325
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	Notch2	IMP	MGI:MGI:1933205	Mouse	PMID:11861489
Biological Process	GO:0035264	multicellular organism growth	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0043011	myeloid dendritic cell differentiation	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23913046
Biological Process	GO:0010629	negative regulation of gene expression	NOTCH2	IDA		Human	PMID:11306509
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23676271
Biological Process	GO:0007219	Notch signaling pathway	NOTCH2	IDA		Human	PMID:11306509
Biological Process	GO:0007219	Notch signaling pathway	NOTCH2	IDA		Human	PMID:25985737
Biological Process	GO:0007219	Notch signaling pathway	Notch2	IDA		Mouse	PMID:34635817
Biological Process	GO:1990798	pancreas regeneration	notch2	IMP	ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:26963759
Biological Process	GO:0060674	placenta blood vessel development	Notch2	IMP	MGI:MGI:1857783	Mouse	PMID:17359302
Biological Process	GO:0001890	placenta development	Notch2	IMP	MGI:MGI:1857783	Mouse	PMID:17359302
Biological Process	GO:0072015	podocyte development	Notch2	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0043065	positive regulation of apoptotic process	Notch2	IGI	MGI:MGI:97363	Mouse	PMID:16169548
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23676271
Biological Process	GO:0008284	positive regulation of cell population proliferation	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:23676271
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	NOTCH2	IDA		Human	PMID:11306509
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	NOTCH2	IDA		Human	PMID:18469519
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	Notch2	IDA		Mouse	MGI:MGI:3814108\|PMID:18710934
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	NOTCH2	IDA		Human	PMID:11306509
Biological Process	GO:0072014	proximal tubule development	Notch2	IEP		Mouse	MGI:MGI:3576186\|PMID:15821257
Biological Process	GO:0003184	pulmonary valve morphogenesis	NOTCH2	IMP		Human	PMID:16773578
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	NOTCH2	IDA		Human	PMID:18469519
Biological Process	GO:2001204	regulation of osteoclast development	NOTCH2	IMP		Human	PMID:29149593
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Notch2	IMP	MGI:MGI:3617328	Mouse	PMID:25446530
Biological Process	GO:0042246	tissue regeneration	Notch2	IEP		Rat	PMID:16118793\|RGD:1581404
Biological Process	GO:0042246	tissue regeneration	notch2	IEP		Zfish	PMID:16205622
Biological Process	GO:0001944	vasculature development	notch2	IMP	ZFIN:ZDB-GENO-150508-1	Zfish	PMID:25230933
Biological Process	GO:0001944	vasculature development	notch2	IMP	ZFIN:ZDB-MRPHLNO-150129-1	Zfish	PMID:25230933
Biological Process	GO:0042060	wound healing	Notch2	IDA		Mouse	MGI:MGI:3691907\|PMID:12496659
Biological Process	GO:0042060	wound healing	Notch2	IEP		Rat	PMID:11549580\|RGD:13506277

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.