Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOTCH3
  • Mouse genes Notch3
  • Rat genes Notch3
  • Zfish genes notch3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Notch3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	NOTCH3	HDA		Human	PMID:25468996
Molecular Function	GO:0019899	enzyme binding	Notch3	IPI	UniProtKB:Q9NWT6	Mouse	MGI:MGI:5318027|PMID:17573339
Molecular Function	GO:0042802	identical protein binding	NOTCH3	IPI	UniProtKB:Q9UM47	Human	PMID:26051713
Molecular Function	GO:0005515	protein binding	NOTCH3	IPI	UniProtKB:O00548	Human	PMID:11006133
Molecular Function	GO:0005515	protein binding	NOTCH3	IPI	UniProtKB:P78504	Human	PMID:11006133
Molecular Function	GO:0005515	protein binding	NOTCH3	IPI	UniProtKB:Q92585	Human	PMID:11101851
Molecular Function	GO:0005515	protein binding	NOTCH3	IPI	UniProtKB:P25786	Human	PMID:17292860
Molecular Function	GO:0005515	protein binding	NOTCH3	IPI	UniProtKB:Q9R1P4	Human	PMID:17292860
Molecular Function	GO:0005515	protein binding	NOTCH3	IPI	UniProtKB:P86480	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Notch3	IPI	UniProtKB:Q9QXX0	Mouse	MGI:MGI:1347427|PMID:10551863
Molecular Function	GO:0005515	protein binding	Notch3	IPI	UniProtKB:Q77CA8	Mouse	MGI:MGI:5693363|PMID:21191019
Molecular Function	GO:0005515	protein binding	Notch3	IPI	PR:P31266	Mouse	PMID:9111338
Molecular Function	GO:0038023	signaling receptor activity	NOTCH3	IMP		Human	PMID:15350543
Cellular Component	GO:0015629	actin cytoskeleton	NOTCH3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	NOTCH3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NOTCH3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Notch3	IDA		Mouse	MGI:MGI:5693363|PMID:21191019
Cellular Component	GO:0005886	plasma membrane	NOTCH3	IDA		Human	PMID:15350543
Cellular Component	GO:0005886	plasma membrane	Notch3	IDA		Mouse	PMID:17079689
Cellular Component	GO:0043235	receptor complex	NOTCH3	IDA		Human	PMID:23382219
Biological Process	GO:0060842	arterial endothelial cell differentiation	notch3	IMP	ZFIN:ZDB-GENO-131003-1	Zfish	PMID:24598161
Biological Process	GO:0048844	artery morphogenesis	Notch3	IMP	MGI:MGI:2687010	Mouse	PMID:23117660
Biological Process	GO:0097746	blood vessel diameter maintenance	notch3	IMP	ZFIN:ZDB-GENO-131121-3	Zfish	PMID:23720232
Biological Process	GO:0097746	blood vessel diameter maintenance	notch3	IMP	ZFIN:ZDB-GENO-131204-5	Zfish	PMID:23720232
Biological Process	GO:0048514	blood vessel morphogenesis	notch3	IMP	ZFIN:ZDB-GENO-131204-5	Zfish	PMID:23720232
Biological Process	GO:0048514	blood vessel morphogenesis	notch3	IMP	ZFIN:ZDB-GENO-131121-3	Zfish	PMID:23720232
Biological Process	GO:0035907	dorsal aorta development	notch3	IGI	ZFIN:ZDB-GENO-131003-1,ZFIN:ZDB-MRPHLNO-140808-3	Zfish	PMID:24598161
Biological Process	GO:0035907	dorsal aorta development	notch3	IGI	ZFIN:ZDB-MRPHLNO-070614-5,ZFIN:ZDB-MRPHLNO-140808-3	Zfish	PMID:25230933
Biological Process	GO:0035907	dorsal aorta development	notch3	IGI	ZFIN:ZDB-GENO-131003-1,ZFIN:ZDB-MRPHLNO-070328-2	Zfish	PMID:24598161
Biological Process	GO:0035907	dorsal aorta development	notch3	IMP	ZFIN:ZDB-GENO-131003-1	Zfish	PMID:24598161
Biological Process	GO:0030900	forebrain development	Notch3	IGI	MGI:MGI:97363	Mouse	PMID:16120638
Biological Process	GO:0072104	glomerular capillary formation	Notch3	IEP		Mouse	MGI:MGI:3576186|PMID:15821257
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	notch3	IMP	ZFIN:ZDB-MRPHLNO-070614-5	Zfish	PMID:25230933
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	notch3	IGI	ZFIN:ZDB-MRPHLNO-070614-5,ZFIN:ZDB-MRPHLNO-081030-1	Zfish	PMID:25230933
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	notch3	IGI	ZFIN:ZDB-MRPHLNO-070614-5,ZFIN:ZDB-MRPHLNO-140808-3	Zfish	PMID:25230933
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	notch3	IGI	ZFIN:ZDB-GENO-100412-15,ZFIN:ZDB-MRPHLNO-070614-5	Zfish	PMID:25230933
Biological Process	GO:0001889	liver development	notch3	IGI	ZFIN:ZDB-GENE-011128-3	Zfish	PMID:15509774
Biological Process	GO:0001889	liver development	notch3	IGI	ZFIN:ZDB-GENE-000329-4	Zfish	PMID:15509774
Biological Process	GO:0001889	liver development	notch3	IMP		Zfish	PMID:15509774
Biological Process	GO:0035633	maintenance of blood-brain barrier	notch3	IMP	ZFIN:ZDB-GENO-131003-1	Zfish	PMID:24306108
Biological Process	GO:0045596	negative regulation of cell differentiation	Notch3	IMP		Mouse	PMID:15064243
Biological Process	GO:0050768	negative regulation of neurogenesis	notch3	IGI	ZFIN:ZDB-MRPHLNO-041207-4,ZFIN:ZDB-MRPHLNO-041207-7	Zfish	PMID:20118921
Biological Process	GO:0050768	negative regulation of neurogenesis	notch3	IEP		Zfish	PMID:20534844
Biological Process	GO:0045665	negative regulation of neuron differentiation	Notch3	IMP		Mouse	PMID:15064243
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Notch3	IMP	MGI:MGI:2687010	Mouse	PMID:23117660
Biological Process	GO:0001840	neural plate development	notch3	IGI	ZFIN:ZDB-MRPHLNO-041207-4,ZFIN:ZDB-MRPHLNO-041207-7	Zfish	PMID:17134690
Biological Process	GO:0014016	neuroblast differentiation	Notch3	IMP		Mouse	PMID:15064243
Biological Process	GO:0030182	neuron differentiation	Notch3	IMP		Mouse	PMID:15064243
Biological Process	GO:0048663	neuron fate commitment	Notch3	IGI	MGI:MGI:97363	Mouse	PMID:16120638
Biological Process	GO:0097150	neuronal stem cell population maintenance	notch3	IMP	ZFIN:ZDB-GENO-131003-1	Zfish	PMID:23863484
Biological Process	GO:0007219	Notch signaling pathway	Notch3	IDA		Mouse	MGI:MGI:4367619|PMID:19855400
Biological Process	GO:0007219	Notch signaling pathway	Notch3	IDA		Rat	PMID:11925448|RGD:632418
Biological Process	GO:0007219	Notch signaling pathway	notch3	IGI	ZFIN:ZDB-MRPHLNO-041207-4,ZFIN:ZDB-MRPHLNO-041207-7	Zfish	PMID:19056830
Biological Process	GO:0014003	oligodendrocyte development	notch3	IMP	ZFIN:ZDB-GENO-131121-3	Zfish	PMID:23720232
Biological Process	GO:0048709	oligodendrocyte differentiation	notch3	IMP	ZFIN:ZDB-GENO-131121-3	Zfish	PMID:23720232
Biological Process	GO:0048709	oligodendrocyte differentiation	notch3	IMP	ZFIN:ZDB-GENO-131204-5	Zfish	PMID:23720232
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	notch3	IGI	ZFIN:ZDB-MRPHLNO-041207-4,ZFIN:ZDB-MRPHLNO-041207-7,ZFIN:ZDB-MRPHLNO-070508-1	Zfish	PMID:19084503
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Notch3	IDA		Mouse	MGI:MGI:4367619|PMID:19855400
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Notch3	IMP	MGI:MGI:2687010	Mouse	PMID:23117660
Biological Process	GO:0048793	pronephros development	notch3	IMP	ZFIN:ZDB-MRPHLNO-070611-3	Zfish	PMID:17287248
Biological Process	GO:0006355	regulation of DNA-templated transcription	Notch3	IDA		Rat	PMID:11971902|RGD:625426
Biological Process	GO:0048259	regulation of receptor-mediated endocytosis	notch3	IGI	ZFIN:ZDB-MRPHLNO-041207-4,ZFIN:ZDB-MRPHLNO-041207-7	Zfish	PMID:19056830
Biological Process	GO:0043114	regulation of vascular permeability	notch3	IMP	ZFIN:ZDB-GENO-131003-1	Zfish	PMID:24306108
Biological Process	GO:0021654	rhombomere boundary formation	notch3	IGI	ZFIN:ZDB-GENO-110113-7,ZFIN:ZDB-MRPHLNO-041207-7	Zfish	PMID:19705151
Biological Process	GO:0061056	sclerotome development	notch3	IGI	ZFIN:ZDB-MRPHLNO-070614-5,ZFIN:ZDB-MRPHLNO-081030-1	Zfish	PMID:25230933
Biological Process	GO:0061056	sclerotome development	notch3	IGI	ZFIN:ZDB-GENO-100412-15,ZFIN:ZDB-MRPHLNO-070614-5	Zfish	PMID:25230933
Biological Process	GO:0061056	sclerotome development	notch3	IMP	ZFIN:ZDB-MRPHLNO-070614-5	Zfish	PMID:25230933
Biological Process	GO:0035019	somatic stem cell population maintenance	notch3	IEP		Zfish	PMID:20534844
Biological Process	GO:0098725	symmetric cell division	notch3	IMP		Zfish	PMID:23863484
Biological Process	GO:0042246	tissue regeneration	Notch3	IEP		Rat	PMID:16118793|RGD:1581404
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	notch3	IGI	ZFIN:ZDB-GENE-990415-173	Zfish	PMID:24768892
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	notch3	IGI	ZFIN:ZDB-GENE-990415-173,ZFIN:ZDB-GENE-990415-183	Zfish	PMID:24768892
Biological Process	GO:0042060	wound healing	Notch3	IEP		Rat	PMID:11549580|RGD:13506277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern