Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOTCH4
  • Mouse genes Notch4
  • Rat genes Notch4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Notch4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005112	Notch binding	Notch4	IPI	PR:Q01705	Mouse	PMID:24667410
Molecular Function	GO:0005515	protein binding	NOTCH4	IPI	UniProtKB:Q92585	Human	PMID:11101851
Molecular Function	GO:0005515	protein binding	NOTCH4	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NOTCH4	IPI	UniProtKB:Q86Y01	Human	PMID:7671825
Molecular Function	GO:0005515	protein binding	Notch4	IPI	UniProtKB:Q93794	Mouse	MGI:MGI:4418643|PMID:9389650
Molecular Function	GO:0005515	protein binding	Notch4	IPI	PR:Q9QXT5	Mouse	PMID:20947685
Molecular Function	GO:0005515	protein binding	Notch4	IPI	PR:P31266	Mouse	PMID:9111338
Molecular Function	GO:0005515	protein binding	Notch4	IPI	PR:Q9JI71	Mouse	PMID:20947685
Cellular Component	GO:0009986	cell surface	NOTCH4	IDA		Human	PMID:11823422
Cellular Component	GO:0031410	cytoplasmic vesicle	Notch4	IDA		Mouse	PMID:24667410
Cellular Component	GO:0005783	endoplasmic reticulum	Notch4	IDA		Mouse	PMID:24667410
Cellular Component	GO:0005634	nucleus	Notch4	IDA		Rat	PMID:21209419|RGD:155663486
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Notch4	IMP		Mouse	MGI:MGI:1934537|PMID:11344305
Biological Process	GO:0045446	endothelial cell differentiation	Notch4	IDA		Rat	PMID:10964583|RGD:1304484
Biological Process	GO:0001886	endothelial cell morphogenesis	Notch4	IDA		Rat	PMID:10964583|RGD:1304484
Biological Process	GO:0001837	epithelial to mesenchymal transition	NOTCH4	IMP		Human	PMID:17984306
Biological Process	GO:0001554	luteolysis	Notch4	IEP		Rat	PMID:21209419|RGD:155663486
Biological Process	GO:0030879	mammary gland development	NOTCH4	IDA		Human	PMID:9576833
Biological Process	GO:0001763	morphogenesis of a branching structure	Notch4	IMP		Mouse	MGI:MGI:1934537|PMID:11344305
Biological Process	GO:0060354	negative regulation of cell adhesion molecule production	NOTCH4	IMP		Human	PMID:17984306
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	NOTCH4	IMP		Human	PMID:17984306
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	Notch4	IMP		Mouse	MGI:MGI:1934537|PMID:11344305
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Notch4	IDA		Mouse	PMID:24667410
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NOTCH4	IMP		Human	PMID:17984306
Biological Process	GO:0045766	positive regulation of angiogenesis	Notch4	IMP	MGI:MGI:1929139	Mouse	PMID:24667410
Biological Process	GO:0045766	positive regulation of angiogenesis	Notch4	IMP	MGI:MGI:4842905	Mouse	PMID:24667410
Biological Process	GO:1903849	positive regulation of aorta morphogenesis	Notch4	IMP		Mouse	PMID:18952909
Biological Process	GO:0008593	regulation of Notch signaling pathway	Notch4	IGI	MGI:MGI:97363	Mouse	PMID:24667410
Biological Process	GO:0032880	regulation of protein localization	Notch4	IDA		Mouse	PMID:24667410
Biological Process	GO:0070613	regulation of protein processing	Notch4	IDA		Mouse	PMID:24667410
Biological Process	GO:0001944	vasculature development	Notch4	IMP		Mouse	MGI:MGI:1934537|PMID:11344305
Biological Process	GO:0048845	venous blood vessel morphogenesis	Notch4	IMP		Mouse	PMID:18952909
Biological Process	GO:0042060	wound healing	Notch4	IEP		Rat	PMID:11549580|RGD:13506277

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern