Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOTUM
  • Mouse genes Notum
  • Rat genes Notum
  • Zfish genes notum1a,notum1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Notum

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016298	lipase activity	Notum	IDA		Mouse	PMID:30622831
Molecular Function	GO:1990699	palmitoleyl hydrolase activity	NOTUM	IDA		Human	PMID:25731175
Molecular Function	GO:1990699	palmitoleyl hydrolase activity	Notum	IDA		Mouse	MGI:MGI:5640887|PMID:25771893
Molecular Function	GO:0005515	protein binding	NOTUM	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Biological Process	GO:0009952	anterior/posterior pattern specification	notum1a	IMP		Zfish	PMID:23293289
Biological Process	GO:0060348	bone development	NOTUM	IMP		Human	PMID:30622831
Biological Process	GO:0060348	bone development	Notum	IMP	MGI:MGI:4214308	Mouse	PMID:30622831
Biological Process	GO:0060348	bone development	Notum	IMP		Mouse	PMID:30622831
Biological Process	GO:0060348	bone development	Notum	IMP		Rat	PMID:30622831|RGD:127285401
Biological Process	GO:0006507	GPI anchor release	notum1a	IDA		Zfish	PMID:22669824
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Notum	IDA		Mouse	PMID:30622831
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	notum1a	IGI	ZFIN:ZDB-GENE-980526-526,ZFIN:ZDB-MRPHLNO-120807-4	Zfish	PMID:22669824
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	notum1a	IGI	ZFIN:ZDB-MRPHLNO-120725-2	Zfish	PMID:22669824
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	notum1a	IDA		Zfish	PMID:22669824
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	notum1a	IGI	ZFIN:ZDB-MRPHLNO-120724-1	Zfish	PMID:22669824
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	NOTUM	IDA		Human	PMID:25731175
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Notum	IDA		Mouse	MGI:MGI:5640887|PMID:25771893
Biological Process	GO:0021532	neural tube patterning	notum1a	IMP	ZFIN:ZDB-MRPHLNO-120807-5	Zfish	PMID:22669824
Biological Process	GO:1990697	protein depalmitoleylation	NOTUM	IDA		Human	PMID:25731175
Biological Process	GO:1990697	protein depalmitoleylation	Notum	IDA		Mouse	MGI:MGI:5640887|PMID:25771893
Biological Process	GO:0030500	regulation of bone mineralization	NOTUM	IDA		Human	PMID:30622831
Biological Process	GO:0030500	regulation of bone mineralization	NOTUM	IMP		Human	PMID:30622831
Biological Process	GO:0030500	regulation of bone mineralization	Notum	IDA		Mouse	PMID:30622831
Biological Process	GO:0030500	regulation of bone mineralization	Notum	IMP		Mouse	PMID:30622831

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern