Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOX1
  • Mouse genes Nox1
  • Rat genes Nox1
  • Zfish genes nox1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nox1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	Nox1	IMP		Rat	PMID:28317735|RGD:15023473
Molecular Function	GO:0005515	protein binding	NOX1	IPI	UniProtKB:Q86UR1	Human	PMID:16636067
Molecular Function	GO:0005515	protein binding	NOX1	IPI	UniProtKB:Q8NFA2	Human	PMID:16636067
Molecular Function	GO:0005515	protein binding	NOX1	IPI	UniProtKB:Q0VAB0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nox1	IPI	RGD:620573	Rat	PMID:15322091|RGD:1580287
Molecular Function	GO:0031267	small GTPase binding	NOX1	IPI	UniProtKB:P63000	Human	PMID:16636067
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	NOX1	IMP		Human	PMID:18023288
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:18397177
Cellular Component	GO:0005737	cytoplasm	Nox1	IDA		Mouse	PMID:19471020
Cellular Component	GO:0005769	early endosome	NOX1	IDA		Human	PMID:17673675
Cellular Component	GO:0005768	endosome	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:18397177
Cellular Component	GO:0043020	NADPH oxidase complex	NOX1	IDA		Human	PMID:16636067
Cellular Component	GO:0043020	NADPH oxidase complex	Nox1	IDA		Rat	PMID:15322091|RGD:1580287
Biological Process	GO:0001525	angiogenesis	NOX1	IMP		Human	PMID:11805326
Biological Process	GO:0016477	cell migration	NOX1	IMP		Human	PMID:18023288
Biological Process	GO:0071455	cellular response to hyperoxia	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:1990451	cellular stress response to acidic pH	NOX1	IDA		Human	PMID:10615049
Biological Process	GO:0030198	extracellular matrix organization	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:16386251
Biological Process	GO:0042743	hydrogen peroxide metabolic process	NOX1	IDA		Human	PMID:11331784
Biological Process	GO:0051454	intracellular pH elevation	NOX1	IDA		Human	PMID:10615049
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:0007254	JNK cascade	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:0000165	MAPK cascade	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:0072592	oxygen metabolic process	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:16386251
Biological Process	GO:0008284	positive regulation of cell population proliferation	NOX1	IDA		Human	PMID:10485709
Biological Process	GO:0045726	positive regulation of integrin biosynthetic process	NOX1	IMP		Human	PMID:18023288
Biological Process	GO:0046330	positive regulation of JNK cascade	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:0043410	positive regulation of MAPK cascade	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:19661248
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Nox1	IMP		Rat	PMID:16254042|RGD:1581408
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Nox1	IMP		Rat	PMID:10485709|RGD:633401
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	NOX1	IEP		Human	PMID:11805326
Biological Process	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:16386251
Biological Process	GO:0000302	response to reactive oxygen species	Nox1	IDA		Rat	PMID:11832489|RGD:625378
Biological Process	GO:0007165	signal transduction	Nox1	IDA		Rat	PMID:10485709|RGD:633401
Biological Process	GO:0042554	superoxide anion generation	NOX1	IDA		Human	PMID:10485709
Biological Process	GO:0042554	superoxide anion generation	NOX1	IMP		Human	PMID:18023288
Biological Process	GO:0042554	superoxide anion generation	Nox1	IMP	MGI:MGI:3616995	Mouse	PMID:18397177
Biological Process	GO:0042554	superoxide anion generation	Nox1	IMP		Rat	PMID:10485709|RGD:633401

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern