Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOX4
  • Mouse genes Nox4
  • Rat genes Nox4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nox4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0072341	modified amino acid binding	NOX4	IDA		Human	PMID:20031578
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	Nox4	IDA		Rat	PMID:11348997|RGD:632514
Molecular Function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	Nox4	IDA		Rat	PMID:15322091|RGD:1580287
Molecular Function	GO:0005515	protein binding	NOX4	IPI	UniProtKB:O00206	Human	PMID:15356101
Molecular Function	GO:0005515	protein binding	NOX4	IPI	UniProtKB:O00206	Human	PMID:17064675
Molecular Function	GO:0005515	protein binding	Nox4	IPI	RGD:620573	Rat	PMID:15322091|RGD:1580287
Molecular Function	GO:1990782	protein tyrosine kinase binding	Nox4	IPI	UniProtKB:P06241	Mouse	MGI:MGI:5811735|PMID:27525436
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	Nox4	IMP		Mouse	MGI:MGI:5009390|PMID:17942966
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	Nox4	IMP		Mouse	PMID:11098048
Cellular Component	GO:0016324	apical plasma membrane	Nox4	IDA		Rat	PMID:19536508|RGD:2317856
Cellular Component	GO:0071944	cell periphery	Nox4	IDA		Mouse	MGI:MGI:3795840|PMID:18431508
Cellular Component	GO:0005925	focal adhesion	Nox4	IDA		Rat	PMID:17511984|RGD:2324670
Cellular Component	GO:0005739	mitochondrion	Nox4	IDA		Mouse	MGI:MGI:5499941|PMID:23624625
Cellular Component	GO:0005739	mitochondrion	Nox4	IDA		Rat	PMID:19706525|RGD:2324657
Cellular Component	GO:0005739	mitochondrion	Nox4	IDA		Rat	PMID:27525436|RGD:13601987
Cellular Component	GO:0043020	NADPH oxidase complex	Nox4	IDA		Rat	PMID:15322091|RGD:1580287
Cellular Component	GO:0005634	nucleus	Nox4	IDA		Rat	PMID:27525436|RGD:13601987
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	Nox4	IDA		Rat	PMID:27525436|RGD:13601987
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nox4	IDA		Mouse	MGI:MGI:3795840|PMID:18431508
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nox4	IDA		Rat	PMID:27525436|RGD:13601987
Cellular Component	GO:0001725	stress fiber	Nox4	IDA		Rat	PMID:17511984|RGD:2324670
Biological Process	GO:0007568	aging	Nox4	IEP		Rat	PMID:19221493|RGD:2324660
Biological Process	GO:0045453	bone resorption	Nox4	IMP		Mouse	PMID:11098048
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nox4	IMP		Mouse	PMID:16775014
Biological Process	GO:0000902	cell morphogenesis	Nox4	IMP		Mouse	MGI:MGI:3694159|PMID:10869423
Biological Process	GO:0071320	cellular response to cAMP	Nox4	IEP		Rat	PMID:18418428|RGD:2324669
Biological Process	GO:0071480	cellular response to gamma radiation	Nox4	IEP		Rat	PMID:18640264|RGD:2317861
Biological Process	GO:0071333	cellular response to glucose stimulus	Nox4	IEP		Mouse	MGI:MGI:3795840|PMID:18431508
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Nox4	IEP		Rat	PMID:18845355|RGD:2324663
Biological Process	GO:0010467	gene expression	NOX4	IMP		Human	PMID:23144758
Biological Process	GO:0003015	heart process	NOX4	IGI	UniProtKB:P06241	Human	PMID:27525436
Biological Process	GO:0003015	heart process	Nox4	IGI	UniProtKB:P39688	Mouse	MGI:MGI:5811735|PMID:27525436
Biological Process	GO:0050667	homocysteine metabolic process	NOX4	IDA		Human	PMID:20031578
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nox4	IMP		Mouse	MGI:MGI:3694159|PMID:10869423
Biological Process	GO:0043065	positive regulation of apoptotic process	Nox4	IMP		Rat	PMID:18848961|RGD:2324662
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Nox4	IMP		Mouse	MGI:MGI:5009390|PMID:17942966
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Nox4	IMP		Mouse	MGI:MGI:5009390|PMID:17942966
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	Nox4	IMP		Rat	PMID:27279484|RGD:151347625
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Nox4	IMP		Mouse	MGI:MGI:5009390|PMID:17942966
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Nox4	IMP		Mouse	MGI:MGI:5009390|PMID:17942966
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Nox4	IDA		Mouse	MGI:MGI:5811735|PMID:27525436
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Nox4	IMP		Rat	PMID:15848200|RGD:2324674
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Nox4	IMP		Rat	PMID:18567639|RGD:2324665
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Nox4	IMP		Rat	PMID:17511984|RGD:2324670
Biological Process	GO:0072593	reactive oxygen species metabolic process	Nox4	IMP		Mouse	MGI:MGI:5009390|PMID:17942966
Biological Process	GO:0001666	response to hypoxia	Nox4	IEP		Rat	PMID:20185631|RGD:2324656
Biological Process	GO:0042554	superoxide anion generation	Nox4	IDA		Mouse	MGI:MGI:3694159|PMID:10869423
Biological Process	GO:0006801	superoxide metabolic process	NOX4	IDA		Human	PMID:18760347
Biological Process	GO:0006801	superoxide metabolic process	Nox4	IDA		Rat	PMID:15322091|RGD:1580287
Biological Process	GO:0006801	superoxide metabolic process	Nox4	IMP		Rat	PMID:15322091|RGD:1580287

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern