Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPC1
  • Mouse genes Npc1
  • Rat genes Npc1
  • Zfish genes npc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	NPC1	IDA		Human	PMID:18772377
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:O75351	Human	PMID:16757520
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:Q5BJF2	Human	PMID:19583955
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:P61916	Human	PMID:20674861
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:Q03135	Human	PMID:25285302
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:X5HMX4	Human	PMID:26771495
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:P61916	Human	PMID:27238017
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:P87666	Human	PMID:27238017
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:Q6IAA8,UniProtKB:Q7L523,UniProtKB:Q8NBW4,UniProtKB:Q9HB90	Human	PMID:28336668
Molecular Function	GO:0005515	protein binding	NPC1	IPI	UniProtKB:P0DTC9	Human	PMID:34450201
Molecular Function	GO:0005515	protein binding	Npc1	IPI	UniProtKB:A0A0F6B1Q8	Mouse	MGI:MGI:6810806|PMID:34237247
Molecular Function	GO:0005515	protein binding	Npc1	IPI	UniProtKB:P79345	Mouse	MGI:MGI:5305553|PMID:22065762
Molecular Function	GO:0005515	protein binding	Npc1	IPI	PR:P46467	Mouse	PMID:16757520
Cellular Component	GO:0005783	endoplasmic reticulum	NPC1	IDA		Human	PMID:12554680
Cellular Component	GO:0005768	endosome	Npc1	IDA		Mouse	PMID:10787428
Cellular Component	GO:0005768	endosome	Npc1	IDA		Mouse	PMID:16757520
Cellular Component	GO:0070062	extracellular exosome	NPC1	HDA		Human	PMID:19056867
Cellular Component	GO:0005576	extracellular region	Npc1	IDA		Mouse	MGI:MGI:5305553|PMID:22065762
Cellular Component	GO:0005794	Golgi apparatus	Npc1	IDA		Mouse	PMID:10787428
Cellular Component	GO:0005765	lysosomal membrane	NPC1	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	NPC1	IDA		Human	PMID:28784760
Cellular Component	GO:0005765	lysosomal membrane	NPC1	IDA		Human	PMID:9927649
Cellular Component	GO:0005764	lysosome	Npc1	IDA		Mouse	MGI:MGI:5305553|PMID:22065762
Cellular Component	GO:0005764	lysosome	Npc1	IDA		Mouse	MGI:MGI:5292275|PMID:21896731
Cellular Component	GO:0005764	lysosome	Npc1	IDA		Mouse	PMID:21289032
Cellular Component	GO:0005764	lysosome	Npc1	IDA		Mouse	PMID:10787428
Cellular Component	GO:0016020	membrane	NPC1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Npc1	IDA		Mouse	PMID:10787428
Cellular Component	GO:0045121	membrane raft	Npc1	IDA		Mouse	PMID:10787428
Cellular Component	GO:0005635	nuclear envelope	NPC1	IDA		Human	PMID:12554680
Cellular Component	GO:0005635	nuclear envelope	Npc1	IDA		Mouse	PMID:20457914
Cellular Component	GO:0048471	perinuclear region of cytoplasm	NPC1	IDA		Human	PMID:12554680
Cellular Component	GO:0005886	plasma membrane	NPC1	IDA		Human	PMID:10821832
Cellular Component	GO:0005886	plasma membrane	Npc1	IDA		Mouse	PMID:10787428
Cellular Component	GO:0031982	vesicle	Npc1	IDA		Mouse	PMID:10787428
Biological Process	GO:0007628	adult walking behavior	Npc1	IGI	MGI:MGI:97180	Mouse	PMID:19074461
Biological Process	GO:0006914	autophagy	NPC1	IGI	UniProtKB:P10636	Human	PMID:19074461
Biological Process	GO:0008015	blood circulation	npc1	IMP	ZFIN:ZDB-GENO-220304-2	Zfish	PMID:33722902
Biological Process	GO:0019725	cellular homeostasis	npc1	IMP	ZFIN:ZDB-GENO-190205-9	Zfish	PMID:29897878
Biological Process	GO:0019725	cellular homeostasis	npc1	IMP	ZFIN:ZDB-GENO-190205-8	Zfish	PMID:29897878
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Npc1	IDA		Mouse	PMID:10787428
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	Npc1	IDA		Mouse	PMID:10787428
Biological Process	GO:0007417	central nervous system development	npc1	IMP	ZFIN:ZDB-GENO-220304-2	Zfish	PMID:33722902
Biological Process	GO:0033344	cholesterol efflux	NPC1	IDA		Human	PMID:16141411
Biological Process	GO:0033344	cholesterol efflux	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:17148552
Biological Process	GO:0042632	cholesterol homeostasis	NPC1	IDA		Human	PMID:12719428
Biological Process	GO:0042632	cholesterol homeostasis	NPC1	IMP		Human	PMID:28784760
Biological Process	GO:0042632	cholesterol homeostasis	NPC1	IMP		Human	PMID:9211849
Biological Process	GO:0042632	cholesterol homeostasis	NPC1	IMP		Human	PMID:9927649
Biological Process	GO:0042632	cholesterol homeostasis	Npc1	IMP		Mouse	MGI:MGI:5292275|PMID:21896731
Biological Process	GO:0042632	cholesterol homeostasis	npc1	IMP	ZFIN:ZDB-GENO-190205-9	Zfish	PMID:29897878
Biological Process	GO:0042632	cholesterol homeostasis	npc1	IMP	ZFIN:ZDB-GENO-190205-8	Zfish	PMID:29897878
Biological Process	GO:0010878	cholesterol storage	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21697390
Biological Process	GO:0030301	cholesterol transport	NPC1	IDA		Human	PMID:18772377
Biological Process	GO:0030301	cholesterol transport	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21697390
Biological Process	GO:0030301	cholesterol transport	npc1	IMP	ZFIN:ZDB-MRPHLNO-110810-1	Zfish	PMID:25860611
Biological Process	GO:0043009	chordate embryonic development	npc1	IMP	ZFIN:ZDB-MRPHLNO-110810-1	Zfish	PMID:23010472
Biological Process	GO:2000900	cyclodextrin metabolic process	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21697390
Biological Process	GO:0006897	endocytosis	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:15078881
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	npc1	IMP	ZFIN:ZDB-MRPHLNO-110810-1	Zfish	PMID:21576600
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	npc1	IMP	ZFIN:ZDB-MRPHLNO-110810-2	Zfish	PMID:21576600
Biological Process	GO:0051649	establishment of localization in cell	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:17148552
Biological Process	GO:0090150	establishment of protein localization to membrane	NPC1	IDA		Human	PMID:23360953
Biological Process	GO:0010467	gene expression	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:29463856
Biological Process	GO:0010467	gene expression	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21289032
Biological Process	GO:0032367	intracellular cholesterol transport	NPC1	IMP		Human	PMID:27238017
Biological Process	GO:0032367	intracellular cholesterol transport	NPC1	IMP		Human	PMID:28784760
Biological Process	GO:0032367	intracellular cholesterol transport	NPC1	IMP		Human	PMID:9211849
Biological Process	GO:0006629	lipid metabolic process	npc1	IMP	ZFIN:ZDB-GENO-220819-1	Zfish	PMID:34061502
Biological Process	GO:0019915	lipid storage	npc1	IMP	ZFIN:ZDB-GENO-220819-1	Zfish	PMID:34061502
Biological Process	GO:0001889	liver development	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21289032
Biological Process	GO:0016236	macroautophagy	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:17468177
Biological Process	GO:0016236	macroautophagy	Npc1	IGI	MGI:MGI:1891828	Mouse	PMID:17468177
Biological Process	GO:0035855	megakaryocyte development	npc1	IMP	ZFIN:ZDB-MRPHLNO-110810-1	Zfish	PMID:23010472
Biological Process	GO:0031579	membrane raft organization	NPC1	IMP		Human	PMID:23360953
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Npc1	IMP		Rat	PMID:22147702|RGD:7247589
Biological Process	GO:0016242	negative regulation of macroautophagy	Npc1	IGI	MGI:MGI:1891828	Mouse	PMID:17468177
Biological Process	GO:0016242	negative regulation of macroautophagy	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:17468177
Biological Process	GO:1904262	negative regulation of TORC1 signaling	NPC1	IDA		Human	PMID:28336668
Biological Process	GO:0022008	neurogenesis	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21697390
Biological Process	GO:0048570	notochord morphogenesis	npc1	IMP	ZFIN:ZDB-GENO-220304-2	Zfish	PMID:33722902
Biological Process	GO:0071599	otic vesicle development	npc1	IMP	ZFIN:ZDB-GENO-220304-2	Zfish	PMID:33722902
Biological Process	GO:0032475	otolith formation	npc1	IMP	ZFIN:ZDB-GENO-220304-2	Zfish	PMID:33722902
Biological Process	GO:0012501	programmed cell death	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21697390
Biological Process	GO:0006486	protein glycosylation	NPC1	IDA		Human	PMID:10821832
Biological Process	GO:0006486	protein glycosylation	Npc1	IDA		Mouse	MGI:MGI:5305553|PMID:22065762
Biological Process	GO:0032383	regulation of intracellular cholesterol transport	npc1	IMP	ZFIN:ZDB-MRPHLNO-110810-1	Zfish	PMID:33079236
Biological Process	GO:0046686	response to cadmium ion	Npc1	IDA		Rat	PMID:12890491|RGD:632349
Biological Process	GO:0001666	response to hypoxia	npc1	IDA		Zfish	PMID:15994372
Biological Process	GO:0009410	response to xenobiotic stimulus	Npc1	IDA		Mouse	PMID:10787428
Biological Process	GO:0016125	sterol metabolic process	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21289032
Biological Process	GO:0016125	sterol metabolic process	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21697390
Biological Process	GO:0015918	sterol transport	Npc1	IMP	MGI:MGI:1857409	Mouse	PMID:21289032
Biological Process	GO:0046718	viral entry into host cell	NPC1	IMP		Human	PMID:21866101
Biological Process	GO:0046718	viral entry into host cell	NPC1	IMP		Human	PMID:21866103
Biological Process	GO:0046718	viral entry into host cell	Npc1	IMP		Mouse	MGI:MGI:5619456|PMID:21866101
Biological Process	GO:0046718	viral entry into host cell	Npc1	IMP		Mouse	MGI:MGI:5289741|PMID:21866103

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern