Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPC1L1
  • Mouse genes Npc1l1
  • Rat genes Npc1l1
  • Zfish genes npc1l1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npc1l1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	NPC1L1	IDA		Human	PMID:21602275
Molecular Function	GO:0015485	cholesterol binding	NPC1L1	IDA		Human	PMID:34407950
Molecular Function	GO:1901363	heterocyclic compound binding	Npc1l1	IPI	CHEBI:49040	Rat	PMID:15928087|RGD:1642188
Molecular Function	GO:0031489	myosin V binding	NPC1L1	IPI	UniProtKB:Q9ULV0	Human	PMID:19542231
Molecular Function	GO:0005515	protein binding	NPC1L1	IPI	UniProtKB:Q7L804	Human	PMID:19542231
Molecular Function	GO:0005515	protein binding	NPC1L1	IPI	UniProtKB:P61916	Human	PMID:22095670
Molecular Function	GO:0005515	protein binding	NPC1L1	IPI	UniProtKB:P49757	Human	PMID:24336247
Molecular Function	GO:0005515	protein binding	NPC1L1	IPI	UniProtKB:Q9UHB6	Human	PMID:29880681
Molecular Function	GO:0005515	protein binding	Npc1l1	IPI	UniProtKB:P21271	Mouse	MGI:MGI:6160379|PMID:29880681
Molecular Function	GO:0005515	protein binding	Npc1l1	IPI	UniProtKB:Q9ERG0	Mouse	MGI:MGI:6160379|PMID:29880681
Molecular Function	GO:0042803	protein homodimerization activity	NPC1L1	IDA		Human	PMID:34407950
Molecular Function	GO:0031267	small GTPase binding	NPC1L1	IPI	UniProtKB:P62491	Human	PMID:19542231
Molecular Function	GO:0008431	vitamin E binding	NPC1L1	IDA		Human	PMID:28315682
Cellular Component	GO:0016324	apical plasma membrane	Npc1l1	IDA		Rat	PMID:17135346|RGD:151665736
Cellular Component	GO:0031526	brush border membrane	Npc1l1	IDA		Rat	PMID:15777641|RGD:1642189
Cellular Component	GO:0005886	plasma membrane	NPC1L1	IDA		Human	PMID:19325169
Cellular Component	GO:0005886	plasma membrane	NPC1L1	IDA		Human	PMID:24336247
Biological Process	GO:0071501	cellular response to sterol depletion	NPC1L1	IDA		Human	PMID:19325169
Biological Process	GO:0006695	cholesterol biosynthetic process	NPC1L1	IMP		Human	PMID:17140581
Biological Process	GO:0042632	cholesterol homeostasis	Npc1l1	IMP	MGI:MGI:3043784	Mouse	PMID:14976318
Biological Process	GO:0070508	cholesterol import	Npc1l1	IDA		Rat	PMID:17135346|RGD:151665736
Biological Process	GO:0030301	cholesterol transport	NPC1L1	IMP		Human	PMID:17140581
Biological Process	GO:0030301	cholesterol transport	NPC1L1	IMP		Human	PMID:24336247
Biological Process	GO:0030301	cholesterol transport	Npc1l1	IMP		Mouse	MGI:MGI:3041314|PMID:14976318
Biological Process	GO:0030299	intestinal cholesterol absorption	NPC1L1	IMP		Human	PMID:17140581
Biological Process	GO:0030299	intestinal cholesterol absorption	Npc1l1	IMP		Mouse	MGI:MGI:3041314|PMID:14976318
Biological Process	GO:0042157	lipoprotein metabolic process	NPC1L1	IMP		Human	PMID:17140581
Biological Process	GO:0014850	response to muscle activity	Npc1l1	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0009410	response to xenobiotic stimulus	Npc1l1	IEP		Rat	PMID:17109865|RGD:1598661
Biological Process	GO:0042360	vitamin E metabolic process	NPC1L1	IDA		Human	PMID:28315682
Biological Process	GO:0051180	vitamin transport	NPC1L1	IDA		Human	PMID:18403720
Biological Process	GO:0051180	vitamin transport	NPC1L1	IDA		Human	PMID:28315682
Biological Process	GO:0051180	vitamin transport	Npc1l1	IDA		Rat	PMID:18403720|RGD:152025526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern