Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPC2
  • Mouse genes Npc2
  • Rat genes Npc2
  • Zfish genes npc2.1,npc2.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	NPC2	IDA		Human	PMID:17018531
Molecular Function	GO:0015485	cholesterol binding	NPC2	IDA		Human	PMID:18772377
Molecular Function	GO:0015485	cholesterol binding	NPC2	IDA		Human	PMID:27238017
Molecular Function	GO:0015485	cholesterol binding	Npc2	IMP		Mouse	MGI:MGI:5465528|PMID:21315718
Molecular Function	GO:0120020	cholesterol transfer activity	NPC2	IDA		Human	PMID:18772377
Molecular Function	GO:0120020	cholesterol transfer activity	NPC2	IDA		Human	PMID:25339683
Molecular Function	GO:0120020	cholesterol transfer activity	NPC2	IDA		Human	PMID:27238017
Molecular Function	GO:0019899	enzyme binding	NPC2	IPI	UniProtKB:Q86SQ9	Human	PMID:15110773
Molecular Function	GO:0005515	protein binding	NPC2	IPI	UniProtKB:Q96PU5	Human	PMID:19664597
Molecular Function	GO:0005515	protein binding	NPC2	IPI	UniProtKB:O15118	Human	PMID:20674861
Molecular Function	GO:0005515	protein binding	NPC2	IPI	UniProtKB:Q9UHC9	Human	PMID:22095670
Molecular Function	GO:0005515	protein binding	NPC2	IPI	UniProtKB:O15118	Human	PMID:27238017
Molecular Function	GO:0005515	protein binding	NPC2	IPI	UniProtKB:Q7Z3B1	Human	PMID:27940359
Cellular Component	GO:0070062	extracellular exosome	NPC2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	NPC2	IMP		Human	PMID:15937921
Cellular Component	GO:0005615	extracellular space	Npc2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005764	lysosome	NPC2	IDA		Human	PMID:25339683
Cellular Component	GO:0005764	lysosome	NPC2	IDA		Human	PMID:11125141
Cellular Component	GO:0005764	lysosome	NPC2	IDA		Human	PMID:15937921
Cellular Component	GO:0005764	lysosome	Npc2	IDA		Mouse	PMID:21289032
Cellular Component	GO:0005764	lysosome	Npc2	IDA		Mouse	PMID:29514215
Biological Process	GO:0008015	blood circulation	npc2.1	IMP	ZFIN:ZDB-GENO-220304-7	Zfish	PMID:33722902
Biological Process	GO:0008015	blood circulation	npc2.1	IMP	ZFIN:ZDB-GENO-220304-5	Zfish	PMID:33722902
Biological Process	GO:0007417	central nervous system development	npc2.1	IMP	ZFIN:ZDB-GENO-220304-5	Zfish	PMID:33722902
Biological Process	GO:0007417	central nervous system development	npc2.1	IMP	ZFIN:ZDB-GENO-220304-7	Zfish	PMID:33722902
Biological Process	GO:0033344	cholesterol efflux	NPC2	IDA		Human	PMID:16141411
Biological Process	GO:0033344	cholesterol efflux	NPC2	IDA		Human	PMID:25339683
Biological Process	GO:0033344	cholesterol efflux	Npc2	IMP		Mouse	MGI:MGI:5465528|PMID:21315718
Biological Process	GO:0042632	cholesterol homeostasis	NPC2	IDA		Human	PMID:12719428
Biological Process	GO:0042632	cholesterol homeostasis	NPC2	IMP		Human	PMID:15937921
Biological Process	GO:0010878	cholesterol storage	Npc2	IMP	MGI:MGI:3044774	Mouse	PMID:21289032
Biological Process	GO:0030301	cholesterol transport	NPC2	IDA		Human	PMID:17018531
Biological Process	GO:0030301	cholesterol transport	NPC2	IDA		Human	PMID:18772377
Biological Process	GO:0030301	cholesterol transport	Npc2	IMP		Mouse	MGI:MGI:5465528|PMID:21315718
Biological Process	GO:0010467	gene expression	Npc2	IMP	MGI:MGI:3044774	Mouse	PMID:21289032
Biological Process	GO:0006954	inflammatory response	npc2.1	IMP	ZFIN:ZDB-GENO-220401-1	Zfish	PMID:33986646
Biological Process	GO:0032367	intracellular cholesterol transport	NPC2	IGI	UniProtKB:Q96E22	Human	PMID:19723497
Biological Process	GO:0032367	intracellular cholesterol transport	NPC2	IMP		Human	PMID:15937921
Biological Process	GO:0032367	intracellular cholesterol transport	NPC2	IDA		Human	PMID:17018531
Biological Process	GO:0032367	intracellular cholesterol transport	NPC2	IDA		Human	PMID:18823126
Biological Process	GO:0032367	intracellular cholesterol transport	NPC2	IMP		Human	PMID:27238017
Biological Process	GO:0032367	intracellular cholesterol transport	Npc2	IMP		Mouse	MGI:MGI:3763329|PMID:17018531
Biological Process	GO:0032366	intracellular sterol transport	NPC2	IDA		Human	PMID:17018531
Biological Process	GO:0061744	motor behavior	npc2.1	IMP	ZFIN:ZDB-GENO-220401-1	Zfish	PMID:33986646
Biological Process	GO:0042552	myelination	npc2.1	IMP	ZFIN:ZDB-GENO-220401-1	Zfish	PMID:33986646
Biological Process	GO:0048570	notochord morphogenesis	npc2.1	IMP	ZFIN:ZDB-GENO-220304-7	Zfish	PMID:33722902
Biological Process	GO:0048570	notochord morphogenesis	npc2.1	IMP	ZFIN:ZDB-GENO-220304-5	Zfish	PMID:33722902
Biological Process	GO:0071599	otic vesicle development	npc2.1	IMP	ZFIN:ZDB-GENO-220304-5	Zfish	PMID:33722902
Biological Process	GO:0071599	otic vesicle development	npc2.1	IMP	ZFIN:ZDB-GENO-220304-7	Zfish	PMID:33722902
Biological Process	GO:0032475	otolith formation	npc2.1	IMP	ZFIN:ZDB-GENO-220304-5	Zfish	PMID:33722902
Biological Process	GO:0032475	otolith formation	npc2.1	IMP	ZFIN:ZDB-GENO-220304-7	Zfish	PMID:33722902
Biological Process	GO:0009615	response to virus	NPC2	IEP		Human	PMID:16548883
Biological Process	GO:0016125	sterol metabolic process	Npc2	IMP	MGI:MGI:3044774	Mouse	PMID:21289032
Biological Process	GO:0015918	sterol transport	Npc2	IMP	MGI:MGI:3044774	Mouse	PMID:21289032

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern