Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPHP4
  • Mouse genes Nphp4
  • Rat genes Nphp4
  • Zfish genes nphp4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nphp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:O15259	Human	PMID:12244321
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:O15259	Human	PMID:15661758
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q14289	Human	PMID:15661758
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q68CZ1-2	Human	PMID:17558407
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q96KN7	Human	PMID:21224891
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:O15259	Human	PMID:21357692
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:O15259	Human	PMID:21565611
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q15051	Human	PMID:21565611
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q68CZ1	Human	PMID:21565611
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q6IE81	Human	PMID:22654112
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q9UPV0	Human	PMID:22863007
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:O15259	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q96KN7	Human	PMID:26638075
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q9ULD6	Human	PMID:26644512
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:O15259	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q68CZ1-2	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	NPHP4	IPI	UniProtKB:Q9Y265	Human	PMID:29959317
Molecular Function	GO:0005515	protein binding	Nphp4	IPI	UniProtKB:Q9QY53	Mouse	MGI:MGI:5013991|PMID:21565611
Molecular Function	GO:0005515	protein binding	Nphp4	IPI	UniProtKB:Q8CG73	Mouse	MGI:MGI:5013991|PMID:21565611
Molecular Function	GO:0005515	protein binding	Nphp4	IPI	MGI:MGI:2144877	Mouse	PMID:29899041
Molecular Function	GO:0005515	protein binding	Nphp4	IPI	PR:Q9R0X5	Mouse	PMID:20664800
Cellular Component	GO:0005911	cell-cell junction	NPHP4	IDA		Human	PMID:21565611
Cellular Component	GO:0005814	centriole	Nphp4	IDA		Mouse	PMID:29038301
Cellular Component	GO:0005813	centrosome	NPHP4	IDA		Human	PMID:21399614
Cellular Component	GO:0036064	ciliary basal body	Nphp4	IDA		Rat	PMID:17558407|RGD:11537356
Cellular Component	GO:0097546	ciliary base	Nphp4	IDA		Mouse	PMID:20169535
Cellular Component	GO:0035869	ciliary transition zone	Nphp4	IDA		Mouse	PMID:20169535
Cellular Component	GO:0005737	cytoplasm	Nphp4	IDA		Mouse	MGI:MGI:5013991|PMID:21565611
Cellular Component	GO:0005829	cytosol	NPHP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	NPHP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	NPHP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NPHP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032391	photoreceptor connecting cilium	Nphp4	IDA		Mouse	PMID:21078623
Cellular Component	GO:0120206	photoreceptor distal connecting cilium	Nphp4	IDA		Mouse	PMID:29899041
Cellular Component	GO:0097470	ribbon synapse	Nphp4	IDA		Mouse	PMID:21078623
Biological Process	GO:0003401	axis elongation	nphp4	IGI	ZFIN:ZDB-GENO-070305-2,ZFIN:ZDB-MRPHLNO-110808-1	Zfish	PMID:21498478
Biological Process	GO:0003401	axis elongation	nphp4	IGI	ZFIN:ZDB-MRPHLNO-041217-5,ZFIN:ZDB-MRPHLNO-110808-1	Zfish	PMID:21498478
Biological Process	GO:0035844	cloaca development	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110808-1	Zfish	PMID:21498478
Biological Process	GO:0035844	cloaca development	nphp4	IGI	ZFIN:ZDB-MRPHLNO-080929-3	Zfish	PMID:21498478
Biological Process	GO:0035844	cloaca development	nphp4	IGI	ZFIN:ZDB-MRPHLNO-110908-2,ZFIN:ZDB-MRPHLNO-110908-4	Zfish	PMID:21596840
Biological Process	GO:0035844	cloaca development	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110908-2	Zfish	PMID:21596840
Biological Process	GO:0060028	convergent extension involved in axis elongation	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110808-1	Zfish	PMID:21498478
Biological Process	GO:0060028	convergent extension involved in axis elongation	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110808-2	Zfish	PMID:21498478
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-3	Zfish	PMID:22550138
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-1	Zfish	PMID:22550138
Biological Process	GO:0071907	determination of digestive tract left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-2	Zfish	PMID:22550138
Biological Process	GO:0061371	determination of heart left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-1	Zfish	PMID:22550138
Biological Process	GO:0061371	determination of heart left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-3	Zfish	PMID:22550138
Biological Process	GO:0061371	determination of heart left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-2	Zfish	PMID:22550138
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-3	Zfish	PMID:22550138
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-1	Zfish	PMID:22550138
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-2	Zfish	PMID:22550138
Biological Process	GO:0071910	determination of liver left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-1	Zfish	PMID:22550138
Biological Process	GO:0071910	determination of liver left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-3	Zfish	PMID:22550138
Biological Process	GO:0071910	determination of liver left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-2	Zfish	PMID:22550138
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-2	Zfish	PMID:22550138
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-1	Zfish	PMID:22550138
Biological Process	GO:0035469	determination of pancreatic left/right asymmetry	nphp4	IMP	ZFIN:ZDB-MRPHLNO-141111-3	Zfish	PMID:22550138
Biological Process	GO:0030317	flagellated sperm motility	Nphp4	IMP	MGI:MGI:3032515	Mouse	PMID:21078623
Biological Process	GO:0070121	Kupffer's vesicle development	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110908-2	Zfish	PMID:21596840
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	NPHP4	IDA		Human	PMID:22654112
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110808-1	Zfish	PMID:21498478
Biological Process	GO:0045494	photoreceptor cell maintenance	Nphp4	IMP	MGI:MGI:3032515	Mouse	PMID:21078623
Biological Process	GO:0035845	photoreceptor cell outer segment organization	Nphp4	IMP	MGI:MGI:3032515	Mouse	PMID:21078623
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	NPHP4	IMP		Human	PMID:19755384
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	nphp4	IDA		Zfish	PMID:21498478
Biological Process	GO:0039021	pronephric glomerulus development	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110808-1	Zfish	PMID:35482924
Biological Process	GO:0048793	pronephros development	nphp4	IGI	ZFIN:ZDB-MRPHLNO-110908-2,ZFIN:ZDB-MRPHLNO-110908-3	Zfish	PMID:21596840
Biological Process	GO:0048793	pronephros development	nphp4	IMP	ZFIN:ZDB-MRPHLNO-110908-2	Zfish	PMID:21596840
Biological Process	GO:0072114	pronephros morphogenesis	nphp4	IGI	ZFIN:ZDB-MRPHLNO-080929-3	Zfish	PMID:21498478
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	nphp4	IGI	ZFIN:ZDB-MRPHLNO-110808-1,ZFIN:ZDB-MRPHLNO-120809-6	Zfish	PMID:22654112
Biological Process	GO:0060041	retina development in camera-type eye	Nphp4	IMP		Mouse	PMID:21052544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern