Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nppa

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NPPA
- Mouse genes Nppa
- Rat genes Nppa
- Zfish genes nppa
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nppa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	Nppa	IDA		Rat	PMID:12608696\|RGD:1626242
Molecular Function	GO:0005179	hormone activity	Nppa	IDA		Rat	PMID:7552344\|RGD:1626243
Molecular Function	GO:0051427	hormone receptor binding	NPPA	IPI	UniProtKB:P16066	Human	PMID:1660465
Molecular Function	GO:0051427	hormone receptor binding	NPPA	IPI	UniProtKB:P17342	Human	PMID:1660465
Molecular Function	GO:0005184	neuropeptide hormone activity	NPPA	IMP		Human	PMID:19646991
Molecular Function	GO:0071855	neuropeptide receptor binding	NPPA	IMP		Human	PMID:19646991
Molecular Function	GO:0005515	protein binding	NPPA	IPI	UniProtKB:P43365	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NPPA	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NPPA	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPPA	IPI	UniProtKB:P43365	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPPA	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nppa	IPI	UniProtKB:P40753	Mouse	PMID:33245046
Molecular Function	GO:0005102	signaling receptor binding	NPPA	IDA		Human	PMID:1672777
Molecular Function	GO:0005102	signaling receptor binding	NPPA	IPI	UniProtKB:P17342	Human	PMID:16870210
Molecular Function	GO:0005102	signaling receptor binding	Nppa	IDA		Rat	PMID:11751587\|RGD:70434
Cellular Component	GO:0005903	brush border	Nppa	IDA		Rat	PMID:1372667\|RGD:14929205
Cellular Component	GO:0062023	collagen-containing extracellular matrix	NPPA	HDA		Human	PMID:27559042
Cellular Component	GO:0005737	cytoplasm	Nppa	IDA		Mouse	PMID:12738802
Cellular Component	GO:0005737	cytoplasm	Nppa	IDA		Rat	PMID:16270351\|RGD:1626336
Cellular Component	GO:0005615	extracellular space	Nppa	IDA		Mouse	PMID:15452027
Cellular Component	GO:0098690	glycinergic synapse	Nppa	EXP		Rat	PMID:24060848\|RGD:155230794
Cellular Component	GO:0098690	glycinergic synapse	Nppa	IDA		Rat	PMID:24060848\|RGD:155230794
Cellular Component	GO:0098690	glycinergic synapse	Nppa	IMP		Rat	PMID:24060848\|RGD:155230794
Cellular Component	GO:0042629	mast cell granule	Nppa	IDA		Rat	PMID:16246270\|RGD:1579983
Cellular Component	GO:0005634	nucleus	Nppa	IDA		Rat	PMID:16270351\|RGD:1626336
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nppa	IDA		Rat	PMID:16270351\|RGD:1626336
Cellular Component	GO:0032991	protein-containing complex	NPPA	IDA		Human	PMID:16870210
Biological Process	GO:0036302	atrioventricular canal development	nppa	IGI	ZFIN:ZDB-GENO-190118-2	Zfish	PMID:29752386
Biological Process	GO:1905072	cardiac jelly development	nppa	IGI	ZFIN:ZDB-GENO-190118-2	Zfish	PMID:29752386
Biological Process	GO:0060038	cardiac muscle cell proliferation	nppa	IMP	ZFIN:ZDB-MRPHLNO-140401-1	Zfish	PMID:24353062
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Nppa	IMP	MGI:MGI:1857231	Mouse	PMID:15452027
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Nppa	IDA		Mouse	PMID:24137001
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Nppa	IMP	MGI:MGI:1857231	Mouse	PMID:14985074
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Nppa	IEP		Rat	PMID:7657802\|RGD:1580138
Biological Process	GO:1904385	cellular response to angiotensin	Nppa	IEP		Rat	PMID:27249171\|RGD:155646134
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Nppa	IEP		Rat	PMID:27249171\|RGD:155646134
Biological Process	GO:0071260	cellular response to mechanical stimulus	Nppa	IEP		Rat	PMID:23617620\|RGD:7297055
Biological Process	GO:0006182	cGMP biosynthetic process	NPPA	IDA		Human	PMID:1672777
Biological Process	GO:0006182	cGMP biosynthetic process	Nppa	IMP		Rat	PMID:10559136\|RGD:619660
Biological Process	GO:0019934	cGMP-mediated signaling	Nppa	IDA		Rat	PMID:12217425\|RGD:729410
Biological Process	GO:0007565	female pregnancy	Nppa	IMP		Mouse	MGI:MGI:5319447\|PMID:22437503
Biological Process	GO:0045776	negative regulation of blood pressure	Nppa	IMP	MGI:MGI:1857231	Mouse	PMID:23542788
Biological Process	GO:0045776	negative regulation of blood pressure	Nppa	IMP	MGI:MGI:1857231	Mouse	PMID:26536903
Biological Process	GO:0045776	negative regulation of blood pressure	Nppa	IMP		Mouse	PMID:23981445
Biological Process	GO:0030308	negative regulation of cell growth	Nppa	IMP		Rat	PMID:16010968\|RGD:1580001
Biological Process	GO:1903815	negative regulation of collecting lymphatic vessel constriction	Nppa	IDA		Rat	PMID:23897233\|RGD:9685538
Biological Process	GO:0043508	negative regulation of JUN kinase activity	NPPA	IDA		Human	PMID:22399583
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Nppa	IDA		Rat	PMID:2136863\|RGD:7247720
Biological Process	GO:0007218	neuropeptide signaling pathway	NPPA	IDA		Human	PMID:19646991
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	NPPA	IMP		Human	PMID:19646991
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Nppa	IDA		Rat	PMID:12608696\|RGD:1626242
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Nppa	IDA		Rat	PMID:7552344\|RGD:1626243
Biological Process	GO:1902261	positive regulation of delayed rectifier potassium channel activity	NPPA	IDA		Human	PMID:19646991
Biological Process	GO:1902261	positive regulation of delayed rectifier potassium channel activity	NPPA	IDA		Human	PMID:8301666
Biological Process	GO:1902261	positive regulation of delayed rectifier potassium channel activity	Nppa	IDA		Rat	PMID:8301666\|RGD:10047161
Biological Process	GO:0010460	positive regulation of heart rate	NPPA	IMP		Human	PMID:19646991
Biological Process	GO:1903595	positive regulation of histamine secretion by mast cell	Nppa	IDA		Rat	PMID:9663691\|RGD:13461752
Biological Process	GO:1903766	positive regulation of potassium ion export across plasma membrane	NPPA	IDA		Human	PMID:19646991
Biological Process	GO:1903766	positive regulation of potassium ion export across plasma membrane	NPPA	IDA		Human	PMID:8301666
Biological Process	GO:1903766	positive regulation of potassium ion export across plasma membrane	Nppa	IDA		Rat	PMID:8301666\|RGD:10047161
Biological Process	GO:0006457	protein folding	NPPA	IDA		Human	PMID:16870210
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	NPPA	IDA		Human	PMID:1672777
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	Nppa	IDA		Rat	PMID:17951249\|RGD:8553616
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	NPPA	IMP		Human	PMID:19646991
Biological Process	GO:0008217	regulation of blood pressure	NPPA	IDA		Human	PMID:6230082
Biological Process	GO:0008217	regulation of blood pressure	NPPA	IDA		Human	PMID:6547996
Biological Process	GO:0008217	regulation of blood pressure	Nppa	IMP		Mouse	MGI:MGI:5319447\|PMID:22437503
Biological Process	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Nppa	IDA		Rat	PMID:8301666\|RGD:10047161
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	Nppa	IDA		Rat	PMID:8301666\|RGD:10047161
Biological Process	GO:0001666	response to hypoxia	Nppa	IEP		Rat	PMID:2136863\|RGD:7247720
Biological Process	GO:0032868	response to insulin	Nppa	IEP		Rat	PMID:16828931\|RGD:2313587
Biological Process	GO:0036376	sodium ion export across plasma membrane	Nppa	IMP	MGI:MGI:1857231	Mouse	PMID:23542788
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Nppa	EXP		Rat	PMID:24060848\|RGD:155230794
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Nppa	IDA		Rat	PMID:24060848\|RGD:155230794
Biological Process	GO:0099538	synaptic signaling via neuropeptide	Nppa	IMP		Rat	PMID:24060848\|RGD:155230794

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.