Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nppb

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NPPB
- Mouse genes Nppb
- Rat genes Nppb
- Zfish genes nppb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nppb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	Nppb	IDA		Rat	PMID:7552344\|RGD:1626243
Molecular Function	GO:0051427	hormone receptor binding	NPPB	IPI	UniProtKB:P17342	Human	PMID:1660465
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:P25788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:P57678	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NPPB	IPI	UniProtKB:Q9UJW9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nppb	IPI	UniProtKB:P05125	Mouse	PMID:33245046
Molecular Function	GO:0005102	signaling receptor binding	NPPB	IPI	UniProtKB:P16066	Human	PMID:12727915
Molecular Function	GO:0005102	signaling receptor binding	NPPB	IDA		Human	PMID:1672777
Molecular Function	GO:0005102	signaling receptor binding	NPPB	IPI	UniProtKB:P17342	Human	PMID:16870210
Cellular Component	GO:0005737	cytoplasm	Nppb	IDA		Rat	PMID:16270351\|RGD:1626336
Cellular Component	GO:0005615	extracellular space	Nppb	IDA		Rat	PMID:17332063\|RGD:1642264
Cellular Component	GO:0005634	nucleus	Nppb	IDA		Rat	PMID:16270351\|RGD:1626336
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nppb	IDA		Rat	PMID:16270351\|RGD:1626336
Cellular Component	GO:0032991	protein-containing complex	NPPB	IDA		Human	PMID:16870210
Cellular Component	GO:0032991	protein-containing complex	NPPB	IDA		Human	PMID:23382219
Cellular Component	GO:0030133	transport vesicle	Nppb	IDA		Rat	PMID:21403100\|RGD:5685657
Biological Process	GO:0036302	atrioventricular canal development	nppb	IGI	ZFIN:ZDB-GENO-190118-2	Zfish	PMID:29752386
Biological Process	GO:1905072	cardiac jelly development	nppb	IGI	ZFIN:ZDB-GENO-190118-2	Zfish	PMID:29752386
Biological Process	GO:0060038	cardiac muscle cell proliferation	nppb	IMP	ZFIN:ZDB-MRPHLNO-150205-1	Zfish	PMID:24353062
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Nppb	IDA		Mouse	PMID:24137001
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	Nppb	IEP		Rat	PMID:7657802\|RGD:1580138
Biological Process	GO:0071260	cellular response to mechanical stimulus	Nppb	IEP		Rat	PMID:21812548\|RGD:5685655
Biological Process	GO:0071260	cellular response to mechanical stimulus	Nppb	IEP		Rat	PMID:23617620\|RGD:7297055
Biological Process	GO:0006182	cGMP biosynthetic process	NPPB	IDA		Human	PMID:1672777
Biological Process	GO:0060976	coronary vasculature development	Nppb	IDA		Mouse	PMID:33245046
Biological Process	GO:0001935	endothelial cell proliferation	Nppb	IDA		Mouse	PMID:33245046
Biological Process	GO:0007507	heart development	Nppb	IEP		Rat	PMID:8027030\|RGD:1580142
Biological Process	GO:0048872	homeostasis of number of cells	Nppb	IDA		Mouse	PMID:33245046
Biological Process	GO:0006954	inflammatory response	Nppb	IEP		Rat	PMID:15081310\|RGD:1580141
Biological Process	GO:0000165	MAPK cascade	Nppb	IDA		Mouse	PMID:33245046
Biological Process	GO:0030308	negative regulation of cell growth	Nppb	IDA		Rat	PMID:17487460\|RGD:2324687
Biological Process	GO:1904055	negative regulation of cholangiocyte proliferation	Nppb	IDA		Rat	PMID:28416225\|RGD:14701038
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Nppb	IDA		Rat	PMID:19104909\|RGD:2324682
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Nppb	IDA		Rat	PMID:21403100\|RGD:5685657
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	Nppb	IDA		Rat	PMID:8289999\|RGD:7247315
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Nppb	IDA		Rat	PMID:7552344\|RGD:1626243
Biological Process	GO:1903816	positive regulation of collecting lymphatic vessel constriction	Nppb	IDA		Rat	PMID:23897233\|RGD:9685538
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Nppb	IDA		Rat	PMID:8289999\|RGD:7247315
Biological Process	GO:0035810	positive regulation of urine volume	Nppb	IDA		Rat	PMID:8289999\|RGD:7247315
Biological Process	GO:0006457	protein folding	NPPB	IDA		Human	PMID:16870210
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	NPPB	IDA		Human	PMID:1672777
Biological Process	GO:0051592	response to calcium ion	Nppb	IEP		Rat	PMID:17332063\|RGD:1642264
Biological Process	GO:0001666	response to hypoxia	Nppb	IEP		Rat	PMID:17822384\|RGD:1642261
Biological Process	GO:0032496	response to lipopolysaccharide	Nppb	IEP		Rat	PMID:22224641\|RGD:5685643
Biological Process	GO:0031667	response to nutrient levels	Nppb	IDA		Mouse	PMID:33245046
Biological Process	GO:0014070	response to organic cyclic compound	Nppb	IEP		Rat	PMID:17673002\|RGD:1642263
Biological Process	GO:0070482	response to oxygen levels	Nppb	IDA		Mouse	PMID:33245046
Biological Process	GO:0043434	response to peptide hormone	Nppb	IEP		Rat	PMID:17919123\|RGD:2324686
Biological Process	GO:0009410	response to xenobiotic stimulus	Nppb	IEP		Rat	PMID:17767048\|RGD:1642262

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.