Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPPC
  • Mouse genes Nppc
  • Rat genes Nppc
  • Zfish genes nppc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nppc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	Nppc	IDA		Rat	PMID:12746286|RGD:1580115
Molecular Function	GO:0005179	hormone activity	Nppc	IDA		Rat	PMID:14691198|RGD:1601491
Molecular Function	GO:0051427	hormone receptor binding	NPPC	IPI	UniProtKB:P20594	Human	PMID:1660465
Molecular Function	GO:0005102	signaling receptor binding	NPPC	IPI	UniProtKB:P20594	Human	PMID:1672777
Molecular Function	GO:0005102	signaling receptor binding	NPPC	IPI	UniProtKB:P17342	Human	PMID:16870210
Molecular Function	GO:0005102	signaling receptor binding	NPPC	IPI	UniProtKB:P20594	Human	PMID:16870210
Molecular Function	GO:0005102	signaling receptor binding	NPPC	IPI	UniProtKB:P20594	Human	PMID:26980729
Molecular Function	GO:0005102	signaling receptor binding	Nppc	IDA		Mouse	PMID:14514678
Cellular Component	GO:0005615	extracellular space	Nppc	IDA		Rat	PMID:16677483|RGD:1642268
Cellular Component	GO:0032991	protein-containing complex	NPPC	IDA		Human	PMID:16870210
Cellular Component	GO:0030141	secretory granule	Nppc	IDA		Rat	PMID:19666697|RGD:7327142
Biological Process	GO:0001525	angiogenesis	Nppc	IMP		Mouse	PMID:30586761
Biological Process	GO:0001525	angiogenesis	Nppc	IMP	MGI:MGI:5660304	Mouse	PMID:30586761
Biological Process	GO:0048513	animal organ development	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:17439653
Biological Process	GO:0001974	blood vessel remodeling	Nppc	IMP		Mouse	PMID:30586761
Biological Process	GO:0001974	blood vessel remodeling	Nppc	IMP	MGI:MGI:5660304	Mouse	PMID:30586761
Biological Process	GO:0061939	c-di-GMP signaling	Nppc	IDA		Mouse	PMID:23127564
Biological Process	GO:1904588	cellular response to glycoprotein	Nppc	IDA		Mouse	PMID:22987720
Biological Process	GO:0006182	cGMP biosynthetic process	NPPC	IDA		Human	PMID:1672777
Biological Process	GO:0006182	cGMP biosynthetic process	Nppc	IMP		Mouse	MGI:MGI:2177134|PMID:11259675
Biological Process	GO:0019934	cGMP-mediated signaling	Nppc	IDA		Rat	PMID:14691198|RGD:1601491
Biological Process	GO:0051276	chromosome organization	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:22696190
Biological Process	GO:0001549	cumulus cell differentiation	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:22696190
Biological Process	GO:0035483	gastric emptying	Nppc	IDA		Mouse	PMID:23127564
Biological Process	GO:0003418	growth plate cartilage chondrocyte differentiation	Nppc	IMP		Mouse	MGI:MGI:2177134|PMID:11259675
Biological Process	GO:0003419	growth plate cartilage chondrocyte proliferation	Nppc	IMP		Mouse	MGI:MGI:2177134|PMID:11259675
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Nppc	IDA		Mouse	PMID:28054671
Biological Process	GO:0051321	meiotic cell cycle	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:20947764
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:22696190
Biological Process	GO:0071965	multicellular organismal locomotion	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:29501420
Biological Process	GO:0008285	negative regulation of cell population proliferation	Nppc	IDA		Rat	PMID:17562543|RGD:1642298
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Nppc	IDA		Rat	PMID:12746286|RGD:1580115
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	Nppc	IDA		Rat	PMID:12746286|RGD:1580115
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	NPPC	IDA		Human	PMID:20947764
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:20947764
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:29501420
Biological Process	GO:1900194	negative regulation of oocyte maturation	NPPC	IDA		Human	PMID:20947764
Biological Process	GO:1900194	negative regulation of oocyte maturation	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:20947764
Biological Process	GO:0048599	oocyte development	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:22696190
Biological Process	GO:0001541	ovarian follicle development	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:22696190
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Nppc	IDA		Rat	PMID:12746286|RGD:1580115
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Nppc	IDA		Rat	PMID:9663691|RGD:13461752
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Nppc	IDA		Rat	PMID:17562543|RGD:1642298
Biological Process	GO:1900721	positive regulation of uterine smooth muscle relaxation	Nppc	IDA		Rat	PMID:9663691|RGD:13461752
Biological Process	GO:0009791	post-embryonic development	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:17439653
Biological Process	GO:0006457	protein folding	NPPC	IDA		Human	PMID:16870210
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	NPPC	IDA		Human	PMID:1672777
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	Nppc	IDA		Rat	PMID:17951249|RGD:8553616
Biological Process	GO:0040014	regulation of multicellular organism growth	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:17439653
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	Nppc	IEP		Rat	PMID:11742834|RGD:70639
Biological Process	GO:0022414	reproductive process	Nppc	IMP	UniProtKB:P23582	Mouse	PMID:20947764
Biological Process	GO:0048678	response to axon injury	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:29501420
Biological Process	GO:0036293	response to decreased oxygen levels	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:29501420
Biological Process	GO:0045471	response to ethanol	Nppc	IEP		Rat	PMID:9042593|RGD:1642295
Biological Process	GO:0001666	response to hypoxia	Nppc	IEP		Rat	PMID:16677483|RGD:1642268
Biological Process	GO:0002931	response to ischemia	Nppc	IMP		Mouse	PMID:30586761
Biological Process	GO:0002931	response to ischemia	Nppc	IMP	MGI:MGI:5660304	Mouse	PMID:30586761
Biological Process	GO:0090649	response to oxygen-glucose deprivation	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:29501420
Biological Process	GO:0009611	response to wounding	Nppc	IMP		Mouse	PMID:29501420
Biological Process	GO:0009611	response to wounding	Nppc	IMP	MGI:MGI:2388899	Mouse	PMID:29501420
Biological Process	GO:0009410	response to xenobiotic stimulus	Nppc	IEP		Rat	PMID:11476746|RGD:1642293

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern