Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPR1
  • Mouse genes Npr1
  • Rat genes Npr1
  • Zfish genes npr1a,npr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004383	guanylate cyclase activity	NPR1	IDA		Human	PMID:1672777
Molecular Function	GO:0004383	guanylate cyclase activity	Npr1	IDA		Mouse	PMID:16430226
Molecular Function	GO:0004383	guanylate cyclase activity	Npr1	IDA		Mouse	PMID:11997476
Molecular Function	GO:0004383	guanylate cyclase activity	Npr1	IMP	MGI:MGI:2386604	Mouse	PMID:11997476
Molecular Function	GO:0004383	guanylate cyclase activity	Npr1	IDA		Rat	PMID:1679239|RGD:729136
Molecular Function	GO:0042562	hormone binding	NPR1	IPI	UniProtKB:P16860	Human	PMID:12547834
Molecular Function	GO:0016941	natriuretic peptide receptor activity	NPR1	IDA		Human	PMID:1660465
Molecular Function	GO:0016941	natriuretic peptide receptor activity	NPR1	IDA		Human	PMID:1672777
Molecular Function	GO:0017046	peptide hormone binding	NPR1	IPI	UniProtKB:P01160	Human	PMID:1660465
Molecular Function	GO:0005515	protein binding	Npr1	IPI	RGD:735057	Rat	PMID:11071862|RGD:1299631
Cellular Component	GO:0005886	plasma membrane	Npr1	IDA		Rat	PMID:7552344|RGD:1626243
Cellular Component	GO:0043235	receptor complex	NPR1	IDA		Human	PMID:23382219
Biological Process	GO:0007411	axon guidance	npr1a	IMP	ZFIN:ZDB-GENO-190108-10	Zfish	PMID:29385124
Biological Process	GO:0060038	cardiac muscle cell proliferation	npr1a	IMP	ZFIN:ZDB-MRPHLNO-140401-2,ZFIN:ZDB-MRPHLNO-150206-2	Zfish	PMID:24353062
Biological Process	GO:0007166	cell surface receptor signaling pathway	Npr1	IMP		Rat	PMID:12082097|RGD:1580144
Biological Process	GO:0006182	cGMP biosynthetic process	NPR1	IDA		Human	PMID:1672777
Biological Process	GO:0006182	cGMP biosynthetic process	Npr1	IMP	MGI:MGI:2386604	Mouse	MGI:MGI:2179542|PMID:11997476
Biological Process	GO:0019934	cGMP-mediated signaling	Npr1	IMP		Rat	PMID:12217425|RGD:729410
Biological Process	GO:0019934	cGMP-mediated signaling	Npr1	IMP		Rat	PMID:2563900|RGD:729265
Biological Process	GO:0042417	dopamine metabolic process	Npr1	IMP		Rat	PMID:15544851|RGD:1580153
Biological Process	GO:0035556	intracellular signal transduction	Npr1	IDA		Rat	PMID:11788449|RGD:70580
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Npr1	IMP		Rat	PMID:19104909|RGD:2324682
Biological Process	GO:0071678	olfactory bulb axon guidance	npr1b	IMP	ZFIN:ZDB-GENO-200504-7	Zfish	PMID:26732841
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Npr1	IDA		Rat	PMID:7552344|RGD:1626243
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	NPR1	IDA		Human	PMID:1672777
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	Npr1	IDA		Rat	PMID:7552344|RGD:1626243
Biological Process	GO:0008217	regulation of blood pressure	Npr1	IDA		Mouse	MGI:MGI:2660983|PMID:12727932

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern