Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPR2
  • Mouse genes Npr2
  • Rat genes Npr2
  • Zfish genes npr2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004383	guanylate cyclase activity	NPR2	IDA		Human	PMID:1672777
Molecular Function	GO:0004383	guanylate cyclase activity	NPR2	IMP		Human	PMID:26980729
Molecular Function	GO:0004383	guanylate cyclase activity	Npr2	IDA		Mouse	PMID:26522847
Molecular Function	GO:0004383	guanylate cyclase activity	Npr2	IDA		Mouse	PMID:29199951
Molecular Function	GO:0004383	guanylate cyclase activity	Npr2	IDA		Mouse	PMID:14514678
Molecular Function	GO:0042562	hormone binding	NPR2	IPI	UniProtKB:P23582	Human	PMID:1672777
Molecular Function	GO:0042802	identical protein binding	Npr2	IPI	PR:Q6VVW5	Mouse	PMID:14514678
Molecular Function	GO:0016941	natriuretic peptide receptor activity	NPR2	IDA		Human	PMID:1660465
Molecular Function	GO:0016941	natriuretic peptide receptor activity	NPR2	IDA		Human	PMID:1672777
Molecular Function	GO:0016941	natriuretic peptide receptor activity	NPR2	IMP		Human	PMID:26980729
Molecular Function	GO:0016941	natriuretic peptide receptor activity	Npr2	IDA		Mouse	PMID:14514678
Molecular Function	GO:0017046	peptide hormone binding	NPR2	IPI	UniProtKB:P23582	Human	PMID:1660465
Molecular Function	GO:0017046	peptide hormone binding	NPR2	IPI	UniProtKB:P23582	Human	PMID:26980729
Molecular Function	GO:0017046	peptide hormone binding	Npr2	IMP		Rat	PMID:16537417|RGD:1601488
Molecular Function	GO:0005515	protein binding	NPR2	IPI	UniProtKB:P20594,UniProtKB:P23582	Human	PMID:16870210
Cellular Component	GO:0005929	cilium	Npr2	IDA		Mouse	PMID:28054671
Cellular Component	GO:0005737	cytoplasm	Npr2	IDA		Mouse	PMID:23127564
Cellular Component	GO:0043005	neuron projection	Npr2	IDA		Mouse	PMID:23127564
Cellular Component	GO:0005634	nucleus	Npr2	IDA		Mouse	PMID:23127564
Cellular Component	GO:0005886	plasma membrane	NPR2	IDA		Human	PMID:24001744
Cellular Component	GO:0005886	plasma membrane	NPR2	IDA		Human	PMID:24471569
Cellular Component	GO:0005886	plasma membrane	NPR2	IDA		Human	PMID:26980729
Cellular Component	GO:0005886	plasma membrane	Npr2	IDA		Rat	PMID:7552344|RGD:1626243
Biological Process	GO:0060466	activation of meiosis involved in egg activation	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0060466	activation of meiosis involved in egg activation	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22987720
Biological Process	GO:0060466	activation of meiosis involved in egg activation	Npr2	IMP	MGI:MGI:5911053	Mouse	PMID:26522847
Biological Process	GO:0007409	axonogenesis	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:17954614
Biological Process	GO:0007409	axonogenesis	Npr2	IMP	MGI:MGI:5567995	Mouse	PMID:30249793
Biological Process	GO:0060385	axonogenesis involved in innervation	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:25473838
Biological Process	GO:0008015	blood circulation	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096
Biological Process	GO:0001568	blood vessel development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096
Biological Process	GO:0001974	blood vessel remodeling	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:32394795
Biological Process	GO:0060348	bone development	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:624676
Biological Process	GO:0098868	bone growth	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0098868	bone growth	Npr2	IMP	MGI:MGI:5911053	Mouse	PMID:29199951
Biological Process	GO:0098868	bone growth	Npr2	IMP	MGI:MGI:5567995	Mouse	PMID:30249793
Biological Process	GO:0061939	c-di-GMP signaling	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:20616347
Biological Process	GO:0061939	c-di-GMP signaling	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:23127564
Biological Process	GO:0060038	cardiac muscle cell proliferation	npr2	IMP	ZFIN:ZDB-MRPHLNO-140401-2,ZFIN:ZDB-MRPHLNO-150206-2	Zfish	PMID:24353062
Biological Process	GO:0051216	cartilage development	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:15722353
Biological Process	GO:0051216	cartilage development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0071321	cellular response to cGMP	Npr2	IMP	MGI:MGI:5911053	Mouse	PMID:26522847
Biological Process	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	NPR2	IEP		Human	PMID:14687666
Biological Process	GO:1901653	cellular response to peptide	Npr2	IMP	MGI:MGI:2152891	Mouse	PMID:28054671
Biological Process	GO:0006182	cGMP biosynthetic process	NPR2	IDA		Human	PMID:1672777
Biological Process	GO:0046068	cGMP metabolic process	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:15722353
Biological Process	GO:0019934	cGMP-mediated signaling	Npr2	IDA		Rat	PMID:14691198|RGD:1601491
Biological Process	GO:0007268	chemical synaptic transmission	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:17954614
Biological Process	GO:0002062	chondrocyte differentiation	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0035988	chondrocyte proliferation	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0051276	chromosome organization	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22696190
Biological Process	GO:0048668	collateral sprouting	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:17954614
Biological Process	GO:0048668	collateral sprouting	Npr2	IMP	MGI:MGI:5567995	Mouse	PMID:24431432
Biological Process	GO:0048668	collateral sprouting	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:25473838
Biological Process	GO:0001549	cumulus cell differentiation	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22696190
Biological Process	GO:0048565	digestive tract development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096
Biological Process	GO:0048546	digestive tract morphogenesis	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:20616347
Biological Process	GO:0001958	endochondral ossification	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:15572448
Biological Process	GO:0001958	endochondral ossification	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:15722353
Biological Process	GO:0001958	endochondral ossification	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22987720
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Npr2	IMP	MGI:MGI:5911053	Mouse	PMID:26522847
Biological Process	GO:0097194	execution phase of apoptosis	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:25012822
Biological Process	GO:0030540	female genitalia development	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:15572448
Biological Process	GO:0035483	gastric emptying	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:23127564
Biological Process	GO:0035112	genitalia morphogenesis	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:25012822
Biological Process	GO:0007281	germ cell development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:25012822
Biological Process	GO:0003417	growth plate cartilage development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0003417	growth plate cartilage development	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0060173	limb development	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:15572448
Biological Process	GO:0035108	limb morphogenesis	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0001945	lymph vessel development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096
Biological Process	GO:0000165	MAPK cascade	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0051321	meiotic cell cycle	Npr2	IMP	MGI:MGI:2152891	Mouse	PMID:20947764
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22987720
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22696190
Biological Process	GO:0035264	multicellular organism growth	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:15572448
Biological Process	GO:0035264	multicellular organism growth	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:15722353
Biological Process	GO:0035264	multicellular organism growth	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0035264	multicellular organism growth	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0035264	multicellular organism growth	Npr2	IMP	MGI:MGI:5567995	Mouse	PMID:30249793
Biological Process	GO:0032504	multicellular organism reproduction	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0051447	negative regulation of meiotic cell cycle	Npr2	IMP	MGI:MGI:2152891	Mouse	PMID:20947764
Biological Process	GO:1900194	negative regulation of oocyte maturation	Npr2	IMP	MGI:MGI:2152891	Mouse	PMID:20947764
Biological Process	GO:0021675	nerve development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096
Biological Process	GO:0051402	neuron apoptotic process	Npr2	IMP		Mouse	PMID:29501420
Biological Process	GO:0019228	neuronal action potential	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:25473838
Biological Process	GO:0048599	oocyte development	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22696190
Biological Process	GO:0001541	ovarian follicle development	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22696190
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	Npr2	IDA		Rat	PMID:7552344|RGD:1626243
Biological Process	GO:0036342	post-anal tail morphogenesis	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:17728275
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	NPR2	IDA		Human	PMID:1672777
Biological Process	GO:0007168	receptor guanylyl cyclase signaling pathway	NPR2	IMP		Human	PMID:26980729
Biological Process	GO:0072001	renal system development	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:31220449
Biological Process	GO:0022414	reproductive process	Npr2	IMP	MGI:MGI:2152891	Mouse	PMID:20947764
Biological Process	GO:0071774	response to fibroblast growth factor	Npr2	IMP	MGI:MGI:5911053	Mouse	PMID:29199951
Biological Process	GO:0009725	response to hormone	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:20616347
Biological Process	GO:0034699	response to luteinizing hormone	Npr2	IMP	MGI:MGI:5911053	Mouse	PMID:26522847
Biological Process	GO:1902074	response to salt	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:31220449
Biological Process	GO:0009611	response to wounding	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:31220449
Biological Process	GO:0007605	sensory perception of sound	Npr2	IMP	MGI:MGI:5567993	Mouse	PMID:30275816
Biological Process	GO:0007338	single fertilization	Npr2	IMP	MGI:MGI:4358115	Mouse	PMID:23065701
Biological Process	GO:0007338	single fertilization	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:22696190
Biological Process	GO:0007338	single fertilization	Npr2	IMP	MGI:MGI:2152891	Mouse	PMID:28054671
Biological Process	GO:0048745	smooth muscle tissue development	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096
Biological Process	GO:0007283	spermatogenesis	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:25012822
Biological Process	GO:0001964	startle response	Npr2	IMP	MGI:MGI:5567993	Mouse	PMID:30275816
Biological Process	GO:0007033	vacuole organization	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:25012822
Biological Process	GO:0061042	vascular wound healing	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:32394795
Biological Process	GO:0001570	vasculogenesis	Npr2	IMP	MGI:MGI:3522129	Mouse	PMID:32394795
Biological Process	GO:0021562	vestibulocochlear nerve development	Npr2	IMP	MGI:MGI:5567993	Mouse	PMID:30275816
Biological Process	GO:0021562	vestibulocochlear nerve development	Npr2	IMP		Mouse	PMID:30275816
Biological Process	GO:0021647	vestibulocochlear nerve maturation	Npr2	IMP	MGI:MGI:1856702	Mouse	PMID:25473838
Biological Process	GO:0050872	white fat cell differentiation	Npr2	IMP	MGI:MGI:3774275	Mouse	PMID:32901096

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern