Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nptn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NPTN
- Mouse genes Nptn
- Rat genes Nptn
- Zfish genes nptna,nptnb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nptn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	Nptn	IDA		Rat	PMID:10759566\|RGD:8553916
Molecular Function	GO:0005515	protein binding	NPTN	IPI	UniProtKB:P20020	Human	PMID:30190470
Molecular Function	GO:0005515	protein binding	Nptn	IPI	UniProtKB:G5E829\|UniProtKB:Q6Q477	Mouse	MGI:MGI:6114568\|PMID:28827723
Molecular Function	GO:0044325	transmembrane transporter binding	Nptn	IPI	RGD:2650	Rat	PMID:22389504\|RGD:9835374
Molecular Function	GO:0005105	type 1 fibroblast growth factor receptor binding	Nptn	IDA		Rat	PMID:19952283\|RGD:2325174
Cellular Component	GO:0009986	cell surface	NPTN	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	Nptn	IDA		Rat	PMID:10759566\|RGD:8553916
Cellular Component	GO:0030425	dendrite	Nptn	IDA		Rat	PMID:22389504\|RGD:9835374
Cellular Component	GO:0098982	GABA-ergic synapse	Nptn	IDA		Rat	PMID:22389504\|RGD:9835374
Cellular Component	GO:0098982	GABA-ergic synapse	Nptn	EXP		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0098982	GABA-ergic synapse	Nptn	IDA		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Nptn	EXP		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Nptn	IDA		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0001772	immunological synapse	Nptn	IDA		Mouse	MGI:MGI:6114568\|PMID:28827723
Cellular Component	GO:0060077	inhibitory synapse	Nptn	IDA		Rat	PMID:22389504\|RGD:9835374
Cellular Component	GO:0014069	postsynaptic density	Nptn	IDA		Rat	PMID:10759566\|RGD:8553916
Cellular Component	GO:0098839	postsynaptic density membrane	Nptn	IDA		Rat	PMID:3224275\|RGD:13702266
Cellular Component	GO:0048787	presynaptic active zone membrane	Nptn	EXP		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0048787	presynaptic active zone membrane	Nptn	IDA		Rat	PMID:23622064\|RGD:13702180
Cellular Component	GO:0042734	presynaptic membrane	Nptn	IDA		Rat	PMID:11431460\|RGD:8554780
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Nptn	EXP		Rat	PMID:10759566\|RGD:8553916
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Nptn	IDA		Rat	PMID:10759566\|RGD:8553916
Cellular Component	GO:0097060	synaptic membrane	Nptn	IDA		Rat	PMID:22389504\|RGD:9835374
Cellular Component	GO:0097060	synaptic membrane	Nptn	IDA		Rat	PMID:1573391\|RGD:9835379
Biological Process	GO:1904861	excitatory synapse assembly	Nptn	IMP	MGI:MGI:5621191	Mouse	PMID:24554721
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Nptn	IDA		Rat	PMID:10759566\|RGD:8553916
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Nptn	IMP		Mouse	MGI:MGI:6114568\|PMID:28827723
Biological Process	GO:0060291	long-term synaptic potentiation	Nptn	IDA		Rat	PMID:16925595\|RGD:8554143
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Nptn	IMP	MGI:MGI:5621191	Mouse	PMID:24554721
Biological Process	GO:0001818	negative regulation of cytokine production	Nptn	IMP		Mouse	MGI:MGI:6114568\|PMID:28827723
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Nptn	IDA		Rat	PMID:19952283\|RGD:2325174
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Nptn	IDA		Rat	PMID:21480899\|RGD:9835376
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Nptn	IDA		Rat	PMID:19952283\|RGD:2325174
Biological Process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	Nptn	IDA		Rat	PMID:19952283\|RGD:2325174
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	Nptn	IMP		Rat	PMID:10759566\|RGD:8553916
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Nptn	IMP		Rat	PMID:10759566\|RGD:8553916
Biological Process	GO:0010976	positive regulation of neuron projection development	Nptn	IDA		Rat	PMID:19952283\|RGD:2325174
Biological Process	GO:0010976	positive regulation of neuron projection development	Nptn	IDA		Rat	PMID:21480899\|RGD:9835376
Biological Process	GO:1903829	positive regulation of protein localization	Nptn	IMP		Rat	PMID:22389504\|RGD:9835374
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Nptn	IDA		Rat	PMID:16925595\|RGD:8554143
Biological Process	GO:1902683	regulation of receptor localization to synapse	Nptn	IMP	MGI:MGI:5621191	Mouse	PMID:24554721
Biological Process	GO:0048545	response to steroid hormone	nptna	IEP		Zfish	PMID:28265462
Biological Process	GO:0050808	synapse organization	Nptn	IMP	MGI:MGI:5621191	Mouse	PMID:24554721
Biological Process	GO:0099557	trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	Nptn	EXP		Rat	PMID:10759566\|RGD:8553916
Biological Process	GO:0099557	trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	Nptn	IDA		Rat	PMID:10759566\|RGD:8553916
Biological Process	GO:0008542	visual learning	Nptn	IDA		Rat	PMID:21480899\|RGD:9835376

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.