Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPY2R
  • Mouse genes Npy2r
  • Rat genes Npy2r
  • Zfish genes npy2r,npy2rl
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Npy2r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042923	neuropeptide binding	npy2r	IPI	UniProtKB:Q9I8P2	Zfish	PMID:16257457
Molecular Function	GO:0042923	neuropeptide binding	npy2r	IPI	UniProtKB:Q9I8P3	Zfish	PMID:16257457
Molecular Function	GO:0042923	neuropeptide binding	npy2rl	IDA		Zfish	PMID:21855645
Molecular Function	GO:0004983	neuropeptide Y receptor activity	Npy2r	IDA		Mouse	PMID:10698177
Molecular Function	GO:0004983	neuropeptide Y receptor activity	Npy2r	IDA		Rat	PMID:11408607|RGD:633494
Molecular Function	GO:0001601	peptide YY receptor activity	Npy2r	IDA		Mouse	PMID:10698177
Molecular Function	GO:0001601	peptide YY receptor activity	Npy2r	IDA		Rat	PMID:11408607|RGD:633494
Molecular Function	GO:0005515	protein binding	NPY2R	IPI	UniProtKB:P10082	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	NPY2R	IPI	UniProtKB:A5PKU2	Human	PMID:32296183
Cellular Component	GO:0005929	cilium	NPY2R	IDA		Human	PMID:28154160
Cellular Component	GO:0016020	membrane	Npy2r	IDA		Rat	PMID:11408607|RGD:633494
Cellular Component	GO:0097730	non-motile cilium	Npy2r	IDA		Mouse	PMID:24316073
Cellular Component	GO:0005886	plasma membrane	Npy2r	IDA		Rat	PMID:11985613|RGD:1642590
Cellular Component	GO:0005886	plasma membrane	Npy2r	IDA		Rat	PMID:16231000|RGD:1625497
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Npy2r	IDA		Mouse	PMID:24316073
Biological Process	GO:0007568	aging	Npy2r	IEP		Rat	PMID:21595512|RGD:10448272
Biological Process	GO:0001662	behavioral fear response	Npy2r	IMP		Rat	PMID:11830176|RGD:633496
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	NPY2R	IMP		Human	PMID:19593212
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Npy2r	IMP		Mouse	PMID:24316073
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Npy2r	IMP		Rat	PMID:11408607|RGD:633494
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	Npy2r	IDA		Rat	PMID:12055128|RGD:1642608
Biological Process	GO:2000252	negative regulation of feeding behavior	Npy2r	IDA		Rat	PMID:17671099|RGD:1642504
Biological Process	GO:0031645	negative regulation of nervous system process	Npy2r	IDA		Rat	PMID:16190896|RGD:1642508
Biological Process	GO:0051048	negative regulation of secretion	Npy2r	IMP		Rat	PMID:11408607|RGD:633494
Biological Process	GO:0050805	negative regulation of synaptic transmission	Npy2r	IDA		Rat	PMID:15295007|RGD:1642503
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Npy2r	IMP		Rat	PMID:16190896|RGD:1642508
Biological Process	GO:0007218	neuropeptide signaling pathway	Npy2r	IDA		Mouse	MGI:MGI:1353743|PMID:10698177
Biological Process	GO:0007263	nitric oxide mediated signal transduction	Npy2r	IMP		Rat	PMID:11711887|RGD:1642593
Biological Process	GO:0003151	outflow tract morphogenesis	NPY2R	IMP		Human	PMID:19593212
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Npy2r	IDA		Rat	PMID:15342191|RGD:1580787
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	Npy2r	IDA		Rat	PMID:16378653|RGD:1642507
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Npy2r	IDA		Rat	PMID:17143304|RGD:1642310
Biological Process	GO:0033603	positive regulation of dopamine secretion	Npy2r	IMP		Rat	PMID:17382974|RGD:1642505
Biological Process	GO:0002793	positive regulation of peptide secretion	Npy2r	IDA		Rat	PMID:17143304|RGD:1642310
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Npy2r	IMP		Rat	PMID:10422644|RGD:1642606
Biological Process	GO:0051930	regulation of sensory perception of pain	Npy2r	IDA		Rat	PMID:17143304|RGD:1642310
Biological Process	GO:0046903	secretion	Npy2r	IMP		Rat	PMID:11408607|RGD:633494

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern