Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nr1d1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NR1D1
- Mouse genes Nr1d1
- Rat genes Nr1d1
- Zfish genes nr1d1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr1d1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Nr1d1	IDA		Mouse	PMID:7838158
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr1d1	IDA		Mouse	PMID:7838158
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr1d1	IDA		Mouse	PMID:12150932
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	NR1D1	IDA		Human	PMID:8622974
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	nr1d1	IDA		Zfish	PMID:17496157
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	nr1d1	IMP	ZFIN:ZDB-MRPHLNO-080822-1	Zfish	PMID:17496157
Molecular Function	GO:0070888	E-box binding	Nr1d1	IDA		Mouse	MGI:MGI:3819720\|PMID:18565334
Molecular Function	GO:0020037	heme binding	NR1D1	IDA		Human	PMID:18006707
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:O43257	Human	PMID:17892483
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:Q7Z6Z7	Human	PMID:20534529
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:O75376	Human	PMID:20581824
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:Q99J31	Human	PMID:21874017
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:O54943	Human	PMID:22170608
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:Q16526	Human	PMID:22170608
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:Q8N163	Human	PMID:23398316
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:P06727	Human	PMID:24311788
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:O54943	Human	PMID:24737000
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:O43255	Human	PMID:26392558
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:A0A0S2Z3X1	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:Q969H0	Human	PMID:27238018
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:P48775	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR1D1	IPI	UniProtKB:Q9NZD8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:O08750	Mouse	MGI:MGI:6282946\|PMID:29653076
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:Q8VDP4	Mouse	MGI:MGI:5495335\|PMID:23398316
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:Q99J31	Mouse	MGI:MGI:5303043\|PMID:21874017
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:Q62227	Mouse	MGI:MGI:6275703\|PMID:25212631
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:P07901\|UniProtKB:P11499	Mouse	MGI:MGI:5922302\|PMID:27686098
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:P06493\|UniProtKB:Q969H0	Mouse	MGI:MGI:6282935\|PMID:27238018
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:O54943	Mouse	MGI:MGI:4429726\|PMID:20159955
Molecular Function	GO:0005515	protein binding	Nr1d1	IPI	UniProtKB:P0CAX5	Rat	PMID:21874017\|RGD:8554394
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NR1D1	IDA		Human	PMID:15761026
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NR1D1	IMP		Human	PMID:8622974
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NR1D1	IDA		Human	PMID:19955433
Molecular Function	GO:0043565	sequence-specific DNA binding	nr1d1	IDA		Zfish	PMID:17496157
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR1D1	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	Nr1d1	IDA		Rat	PMID:8474464\|RGD:10448982
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NR1D1	IDA		Human	PMID:18511497
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Nr1d1	IDA		Rat	PMID:8015547\|RGD:10448983
Molecular Function	GO:0001222	transcription corepressor binding	NR1D1	IDA		Human	PMID:15761026
Molecular Function	GO:0001222	transcription corepressor binding	NR1D1	IMP		Human	PMID:18006707
Cellular Component	GO:0000785	chromatin	NR1D1	IDA		Human	PMID:18511497
Cellular Component	GO:0000785	chromatin	nr1d1	IDA		Zfish	PMID:27171500
Cellular Component	GO:0005737	cytoplasm	Nr1d1	IDA		Mouse	MGI:MGI:5303043\|PMID:21874017
Cellular Component	GO:0005737	cytoplasm	Nr1d1	IDA		Mouse	MGI:MGI:6294205\|PMID:29508494
Cellular Component	GO:0005737	cytoplasm	Nr1d1	IDA		Mouse	MGI:MGI:5922302\|PMID:27686098
Cellular Component	GO:0005737	cytoplasm	Nr1d1	IDA		Rat	PMID:24497272\|RGD:10448995
Cellular Component	GO:0030425	dendrite	Nr1d1	IDA		Mouse	MGI:MGI:5303043\|PMID:21874017
Cellular Component	GO:0030425	dendrite	Nr1d1	IDA		Rat	PMID:21874017\|RGD:8554394
Cellular Component	GO:0043197	dendritic spine	Nr1d1	IDA		Mouse	MGI:MGI:5303043\|PMID:21874017
Cellular Component	GO:0043025	neuronal cell body	Nr1d1	IDA		Rat	PMID:21874017\|RGD:8554394
Cellular Component	GO:0016604	nuclear body	NR1D1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nr1d1	IDA		Mouse	MGI:MGI:6294205\|PMID:29508494
Cellular Component	GO:0005634	nucleus	Nr1d1	IDA		Mouse	MGI:MGI:5922302\|PMID:27686098
Cellular Component	GO:0005634	nucleus	Nr1d1	IDA		Mouse	MGI:MGI:5303043\|PMID:21874017
Cellular Component	GO:0005634	nucleus	Nr1d1	IDA		Mouse	PMID:12150932
Biological Process	GO:0006914	autophagy	nr1d1	IMP	ZFIN:ZDB-GENO-161212-1	Zfish	PMID:27171500
Biological Process	GO:0071347	cellular response to interleukin-1	Nr1d1	IDA		Mouse	MGI:MGI:6162161\|PMID:29533925
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NR1D1	IMP		Human	PMID:18511497
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Nr1d1	IDA		Mouse	MGI:MGI:6162161\|PMID:29533925
Biological Process	GO:0042632	cholesterol homeostasis	Nr1d1	IMP		Mouse	MGI:MGI:4360821\|PMID:19721697
Biological Process	GO:0032922	circadian regulation of gene expression	Nr1d1	IMP		Mouse	MGI:MGI:4429726\|PMID:20159955
Biological Process	GO:0032922	circadian regulation of gene expression	nr1d1	IMP	ZFIN:ZDB-GENO-161212-1	Zfish	PMID:27171500
Biological Process	GO:0007623	circadian rhythm	Nr1d1	IEP		Mouse	MGI:MGI:5559671\|PMID:14645221
Biological Process	GO:0007623	circadian rhythm	Nr1d1	IDA		Mouse	PMID:12150932
Biological Process	GO:0007623	circadian rhythm	Nr1d1	IEP		Rat	PMID:24144766\|RGD:10448984
Biological Process	GO:0060086	circadian temperature homeostasis	Nr1d1	IMP		Mouse	MGI:MGI:5527011\|PMID:24162845
Biological Process	GO:0005978	glycogen biosynthetic process	Nr1d1	IMP	UniProtKB:O54943	Mouse	MGI:MGI:4429726\|PMID:20159955
Biological Process	GO:0001678	intracellular glucose homeostasis	NR1D1	IMP		Human	PMID:18006707
Biological Process	GO:0061889	negative regulation of astrocyte activation	Nr1d1	IMP		Mouse	MGI:MGI:6283959\|PMID:30792350
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Nr1d1	IMP		Mouse	MGI:MGI:5527011\|PMID:24162845
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NR1D1	IDA		Human	PMID:15761026
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NR1D1	IMP		Human	PMID:18006707
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NR1D1	IDA		Human	PMID:20070857
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NR1D1	IMP		Human	PMID:21628546
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NR1D1	IDA		Human	PMID:23398316
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:5527011\|PMID:24162845
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IDA		Mouse	MGI:MGI:6282946\|PMID:29653076
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IDA		Mouse	MGI:MGI:6196242\|PMID:30096135
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:4360821\|PMID:19721697
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:3819720\|PMID:18565334
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IDA		Mouse	MGI:MGI:6282985\|PMID:30555544
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:6283959\|PMID:30792350
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IDA		Mouse	MGI:MGI:5303043\|PMID:21874017
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:6294228\|PMID:24794873
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IDA		Mouse	MGI:MGI:5574437\|PMID:24030830
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:3785131\|PMID:18227153
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Nr1d1	IMP		Mouse	MGI:MGI:6283959\|PMID:30792350
Biological Process	GO:0050728	negative regulation of inflammatory response	Nr1d1	IMP		Mouse	MGI:MGI:6162161\|PMID:29533925
Biological Process	GO:1903979	negative regulation of microglial cell activation	Nr1d1	IMP		Mouse	MGI:MGI:6283959\|PMID:30792350
Biological Process	GO:0150079	negative regulation of neuroinflammatory response	Nr1d1	IMP		Mouse	MGI:MGI:6283959\|PMID:30792350
Biological Process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	NR1D1	IMP		Human	PMID:18511497
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NR1D1	IDA		Human	PMID:19955433
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NR1D1	IMP		Human	PMID:18511497
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NR1D1	IDA		Human	PMID:8622974
Biological Process	GO:0009648	photoperiodism	Nr1d1	IEP		Rat	PMID:21076970\|RGD:10448986
Biological Process	GO:0070859	positive regulation of bile acid biosynthetic process	Nr1d1	IMP		Mouse	MGI:MGI:3819720\|PMID:18565334
Biological Process	GO:0070859	positive regulation of bile acid biosynthetic process	Nr1d1	IMP		Mouse	MGI:MGI:4360821\|PMID:19721697
Biological Process	GO:0042753	positive regulation of circadian rhythm	Nr1d1	IDA		Rat	PMID:18946026\|RGD:10448985
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr1d1	IMP		Mouse	MGI:MGI:3819720\|PMID:18565334
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr1d1	IDA		Rat	PMID:22425774\|RGD:8553819
Biological Process	GO:0010498	proteasomal protein catabolic process	Nr1d1	IDA		Mouse	MGI:MGI:5303043\|PMID:21874017
Biological Process	GO:0010498	proteasomal protein catabolic process	Nr1d1	IDA		Mouse	MGI:MGI:3785131\|PMID:18227153
Biological Process	GO:0031648	protein destabilization	Nr1d1	IMP		Mouse	MGI:MGI:5922302\|PMID:27686098
Biological Process	GO:0042752	regulation of circadian rhythm	Nr1d1	IMP		Mouse	MGI:MGI:4360821\|PMID:19721697
Biological Process	GO:0042752	regulation of circadian rhythm	Nr1d1	IMP		Mouse	MGI:MGI:4429726\|PMID:20159955
Biological Process	GO:0042752	regulation of circadian rhythm	Nr1d1	IMP		Mouse	MGI:MGI:6162161\|PMID:29533925
Biological Process	GO:0042752	regulation of circadian rhythm	Nr1d1	IDA		Rat	PMID:22425774\|RGD:8553819
Biological Process	GO:0042749	regulation of circadian sleep/wake cycle	Nr1d1	IMP		Mouse	MGI:MGI:6283959\|PMID:30792350
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nr1d1	IDA		Mouse	PMID:7838158
Biological Process	GO:0045598	regulation of fat cell differentiation	Nr1d1	IMP		Mouse	MGI:MGI:3785131\|PMID:18227153
Biological Process	GO:0010468	regulation of gene expression	nr1d1	IGI	ZFIN:ZDB-GENE-060306-2	Zfish	PMID:27171500
Biological Process	GO:2000489	regulation of hepatic stellate cell activation	Nr1d1	IDA		Rat	PMID:24497272\|RGD:10448995
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Nr1d1	IMP		Mouse	MGI:MGI:5313784\|PMID:22166979
Biological Process	GO:0019216	regulation of lipid metabolic process	Nr1d1	IMP		Mouse	MGI:MGI:4360821\|PMID:19721697
Biological Process	GO:0019216	regulation of lipid metabolic process	Nr1d1	IMP		Mouse	MGI:MGI:5313784\|PMID:22166979
Biological Process	GO:1904059	regulation of locomotor rhythm	nr1d1	IMP	ZFIN:ZDB-GENO-161212-1	Zfish	PMID:27171500
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	Nr1d1	IMP		Mouse	MGI:MGI:5313784\|PMID:22166979
Biological Process	GO:0044321	response to leptin	Nr1d1	IDA		Mouse	MGI:MGI:5313784\|PMID:22166979

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.