Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nr1h2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NR1H2
- Mouse genes Nr1h2
- Rat genes Nr1h2
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr1h2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	NR1H2	IPI	UniProtKB:O95477	Human	PMID:23931754
Molecular Function	GO:0051117	ATPase binding	NR1H2	IPI	UniProtKB:Q86UK0	Human	PMID:23931754
Molecular Function	GO:0031490	chromatin DNA binding	Nr1h2	IDA		Mouse	PMID:29431742
Molecular Function	GO:0003677	DNA binding	Nr1h2	IDA		Mouse	PMID:14739254
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NR1H2	IDA		Human	PMID:9013544
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr1h2	IDA		Rat	PMID:10187832\|RGD:8661622
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr1h2	IMP		Rat	PMID:10187832\|RGD:8661622
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr1h2	IGI	MGI:MGI:98214	Mouse	PMID:7760852
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr1h2	IDA		Mouse	PMID:14739254
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Nr1h2	IDA		Rat	PMID:7892230\|RGD:729016
Molecular Function	GO:0004879	nuclear receptor activity	Nr1h2	IDA		Mouse	PMID:14739254
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Nr1h2	IDA		Mouse	PMID:7760852
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Nr1h2	IDA		Rat	PMID:7892230\|RGD:729016
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Nr1h2	IPI	RGD:3610	Rat	PMID:7971966\|RGD:61674
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P37023	Human	PMID:12393874
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:Q99750	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:Q99750	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P19793	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P48443	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:Q92828	Human	PMID:21331046
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P48443	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P19793	Human	PMID:24561505
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:Q8N163	Human	PMID:25661920
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:O75376	Human	PMID:26120082
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P48443	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	NR1H2	IPI	UniProtKB:P48443	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Nr1h2	IPI	UniProtKB:Q96EB6	Mouse	MGI:MGI:3790014\|PMID:17936707
Molecular Function	GO:0005515	protein binding	Nr1h2	IPI	PR:P41233	Mouse	PMID:23931754
Molecular Function	GO:0005515	protein binding	Nr1h2	IPI	UniProtKB:B2RY21	Mouse	PMID:23931754
Molecular Function	GO:0005515	protein binding	Nr1h2	IPI	RGD:3610	Rat	PMID:9199332\|RGD:1643121
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NR1H2	IDA		Human	PMID:9013544
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr1h2	IMP		Rat	PMID:10187832\|RGD:8661622
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr1h2	IDA		Rat	PMID:7892230\|RGD:729016
Cellular Component	GO:0005737	cytoplasm	NR1H2	IDA		Human	PMID:12393874
Cellular Component	GO:0005634	nucleus	NR1H2	IDA		Human	PMID:12393874
Cellular Component	GO:0005634	nucleus	Nr1h2	IDA		Mouse	MGI:MGI:3822255\|PMID:18806227
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NR1H2	IPI		Human	PMID:27011007
Biological Process	GO:0044255	cellular lipid metabolic process	Nr1h2	IDA		Mouse	PMID:14739254
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h2	IMP		Mouse	MGI:MGI:5553243\|PMID:18055760
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h2	IDA		Mouse	MGI:MGI:3720271\|PMID:17657314
Biological Process	GO:0006351	DNA-templated transcription	Nr1h2	IDA		Mouse	MGI:MGI:3038048\|PMID:14739254
Biological Process	GO:0055088	lipid homeostasis	Nr1h2	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0010887	negative regulation of cholesterol storage	NR1H2	IMP		Human	PMID:17693624
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Nr1h2	IGI	UniProtKB:Q9Z0Y9	Mouse	MGI:MGI:6162335\|PMID:21173252
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NR1H2	IDA		Human	PMID:12393874
Biological Process	GO:0010629	negative regulation of gene expression	Nr1h2	IDA		Rat	PMID:7971966\|RGD:61674
Biological Process	GO:0032369	negative regulation of lipid transport	NR1H2	IMP		Human	PMID:17693624
Biological Process	GO:0048550	negative regulation of pinocytosis	NR1H2	IMP		Human	PMID:17693624
Biological Process	GO:0045861	negative regulation of proteolysis	Nr1h2	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	Nr1h2	IDA		Mouse	MGI:MGI:5548036\|PMID:24206663
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr1h2	IMP		Mouse	MGI:MGI:4453518\|PMID:20388921
Biological Process	GO:0036151	phosphatidylcholine acyl-chain remodeling	Nr1h2	IMP		Mouse	MGI:MGI:5548036\|PMID:24206663
Biological Process	GO:0010875	positive regulation of cholesterol efflux	NR1H2	IMP		Human	PMID:17186944
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Nr1h2	IDA		Mouse	MGI:MGI:3794353\|PMID:16825483
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Nr1h2	IDA		Mouse	MGI:MGI:3720271\|PMID:17657314
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Nr1h2	IGI	MGI:MGI:2676312	Mouse	PMID:23931754
Biological Process	GO:0032376	positive regulation of cholesterol transport	NR1H2	IDA		Human	PMID:16141411
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NR1H2	IDA		Human	PMID:25661920
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	NR1H2	IMP		Human	PMID:17186944
Biological Process	GO:0010628	positive regulation of gene expression	Nr1h2	IDA		Rat	PMID:7971966\|RGD:61674
Biological Process	GO:0090108	positive regulation of high-density lipoprotein particle assembly	Nr1h2	IDA		Mouse	MGI:MGI:3794353\|PMID:16825483
Biological Process	GO:0090108	positive regulation of high-density lipoprotein particle assembly	Nr1h2	IDA		Mouse	MGI:MGI:3720271\|PMID:17657314
Biological Process	GO:0010884	positive regulation of lipid storage	Nr1h2	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0051006	positive regulation of lipoprotein lipase activity	NR1H2	IMP		Human	PMID:17186944
Biological Process	GO:1902895	positive regulation of miRNA transcription	Nr1h2	IDA		Mouse	MGI:MGI:6446466\|PMID:31501273
Biological Process	GO:0090187	positive regulation of pancreatic juice secretion	Nr1h2	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0051247	positive regulation of protein metabolic process	NR1H2	IMP		Human	PMID:17186944
Biological Process	GO:0090340	positive regulation of secretion of lysosomal enzymes	Nr1h2	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H2	IDA		Human	PMID:16141411
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H2	IMP		Human	PMID:17186944
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H2	IDA		Human	PMID:20219900
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H2	IDA		Human	PMID:9013544
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h2	IDA		Mouse	MGI:MGI:3794353\|PMID:16825483
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h2	IDA		Mouse	MGI:MGI:4399022\|PMID:16141411
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h2	IDA		Rat	PMID:10187832\|RGD:8661622
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	NR1H2	IMP		Human	PMID:17186944
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nr1h2	IDA		Mouse	PMID:14739254
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nr1h2	IGI	MGI:MGI:98214	Mouse	PMID:7760852
Biological Process	GO:0031667	response to nutrient levels	Nr1h2	IEP		Rat	PMID:25612518\|RGD:15045599
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Nr1h2	IDA		Rat	PMID:7971966\|RGD:61674

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.