Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nr1h3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NR1H3
- Mouse genes Nr1h3
- Rat genes Nr1h3
- Zfish genes nr1h3
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr1h3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031490	chromatin DNA binding	Nr1h3	IMP	MGI:MGI:2181380	Mouse	PMID:29431742
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr1h3	IDA		Mouse	MGI:MGI:5572907\|PMID:9013544
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr1h3	IDA		Mouse	PMID:14739254
Molecular Function	GO:0003700	DNA-binding transcription factor activity	nr1h3	IDA		Zfish	PMID:18297735
Molecular Function	GO:0004879	nuclear receptor activity	NR1H3	IDA		Human	PMID:19481530
Molecular Function	GO:0004879	nuclear receptor activity	Nr1h3	IDA		Mouse	MGI:MGI:4399016\|PMID:17107947
Molecular Function	GO:0004879	nuclear receptor activity	Nr1h3	IDA		Mouse	PMID:14739254
Molecular Function	GO:0004879	nuclear receptor activity	nr1h3	IDA		Zfish	PMID:18395439
Molecular Function	GO:0004879	nuclear receptor activity	nr1h3	IDA		Zfish	PMID:18297735
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Nr1h3	IPI	RGD:736929	Rat	PMID:7935418\|RGD:61675
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:O60869	Human	PMID:12040021
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P19793	Human	PMID:15722453
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P37231	Human	PMID:15722453
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q03181	Human	PMID:15722453
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q07869-1	Human	PMID:15722453
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q13227	Human	PMID:19481530
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P19793	Human	PMID:20219900
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P19793	Human	PMID:20682316
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q15788	Human	PMID:20682316
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P48443	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:O43463	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:O60341	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q07869	Human	PMID:24713062
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P28702	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P48443	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q8N163	Human	PMID:25661920
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q96EB6	Human	PMID:25661920
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:Q15788	Human	PMID:25962847
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:O75376	Human	PMID:26120082
Molecular Function	GO:0005515	protein binding	NR1H3	IPI	UniProtKB:P48443	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Nr1h3	IPI	UniProtKB:O88559	Mouse	MGI:MGI:5695430\|PMID:25962847
Molecular Function	GO:0005515	protein binding	Nr1h3	IPI	UniProtKB:Q96EB6	Mouse	MGI:MGI:3790014\|PMID:17936707
Molecular Function	GO:0005515	protein binding	Nr1h3	IPI	PR:Q60974	Mouse	PMID:19052228
Molecular Function	GO:0044877	protein-containing complex binding	Nr1h3	IDA		Rat	PMID:7935418\|RGD:61675
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr1h3	IDA		Mouse	MGI:MGI:5572907\|PMID:9013544
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr1h3	IDA		Mouse	PMID:15319426
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr1h3	IDA		Mouse	PMID:14739254
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr1h3	IDA		Rat	PMID:7935418\|RGD:61675
Molecular Function	GO:0032810	sterol response element binding	NR1H3	IDA		Human	PMID:19628791
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NR1H3	IDA		Human	PMID:18511497
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NR1H3	IDA		Human	PMID:19229075
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Nr1h3	IDA		Mouse	MGI:MGI:4399016\|PMID:17107947
Cellular Component	GO:0000785	chromatin	NR1H3	IDA		Human	PMID:18511497
Cellular Component	GO:0005737	cytoplasm	Nr1h3	IDA		Mouse	MGI:MGI:5800596\|PMID:27383786
Cellular Component	GO:0005737	cytoplasm	Nr1h3	IDA		Rat	PMID:16773041\|RGD:1626246
Cellular Component	GO:0005829	cytosol	NR1H3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NR1H3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NR1H3	IDA		Human	PMID:25661920
Cellular Component	GO:0005634	nucleus	Nr1h3	IMP		Mouse	MGI:MGI:5800596\|PMID:27383786
Cellular Component	GO:0005634	nucleus	Nr1h3	IDA		Mouse	PMID:14739254
Cellular Component	GO:0005634	nucleus	Nr1h3	IDA		Rat	PMID:16773041\|RGD:1626246
Cellular Component	GO:0043235	receptor complex	NR1H3	IDA		Human	PMID:18511497
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NR1H3	EXP		Human	PMID:19167885
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NR1H3	IPI		Human	PMID:25416956
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	NR1H3	IDA		Human	PMID:18511497
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Nr1h3	EXP		Mouse	MGI:MGI:6872266\|PMID:19167885
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Nr1h3	IDA		Mouse	MGI:MGI:4399016\|PMID:17107947
Biological Process	GO:0043277	apoptotic cell clearance	NR1H3	IMP		Human	PMID:19628791
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h3	IEP		Rat	PMID:25263431\|RGD:15045610
Biological Process	GO:0043010	camera-type eye development	nr1h3	IMP	ZFIN:ZDB-MRPHLNO-160301-5	Zfish	PMID:26427652
Biological Process	GO:0044255	cellular lipid metabolic process	Nr1h3	IDA		Mouse	PMID:14739254
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NR1H3	IDA		Human	PMID:18511497
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Nr1h3	IDA		Mouse	MGI:MGI:5009771\|PMID:21187453
Biological Process	GO:0042632	cholesterol homeostasis	NR1H3	IDA		Human	PMID:18511497
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h3	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3720271\|PMID:17657314
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h3	IMP		Mouse	MGI:MGI:5553243\|PMID:18055760
Biological Process	GO:0006351	DNA-templated transcription	Nr1h3	IDA		Mouse	MGI:MGI:3038048\|PMID:14739254
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	nr1h3	IMP	ZFIN:ZDB-MRPHLNO-130312-1	Zfish	ZFIN:ZDB-PUB-131205-6
Biological Process	GO:0009755	hormone-mediated signaling pathway	NR1H3	IDA		Human	PMID:7744246
Biological Process	GO:0008286	insulin receptor signaling pathway	Nr1h3	IEP		Rat	PMID:11781314\|RGD:625467
Biological Process	GO:0055088	lipid homeostasis	Nr1h3	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0055088	lipid homeostasis	Nr1h3	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3720271\|PMID:17657314
Biological Process	GO:0055088	lipid homeostasis	nr1h3	IMP	ZFIN:ZDB-MRPHLNO-130312-1	Zfish	ZFIN:ZDB-PUB-131205-6
Biological Process	GO:0006629	lipid metabolic process	Nr1h3	IEP		Rat	PMID:11781314\|RGD:625467
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:7744246
Biological Process	GO:0010887	negative regulation of cholesterol storage	NR1H3	IMP		Human	PMID:17693624
Biological Process	GO:0010887	negative regulation of cholesterol storage	Nr1h3	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3720271\|PMID:17657314
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Nr1h3	IGI	UniProtKB:Q60644	Mouse	MGI:MGI:6162335\|PMID:21173252
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Nr1h3	IMP		Mouse	PMID:12815040
Biological Process	GO:0050728	negative regulation of inflammatory response	Nr1h3	IDA		Mouse	MGI:MGI:5009771\|PMID:21187453
Biological Process	GO:0032369	negative regulation of lipid transport	NR1H3	IMP		Human	PMID:17693624
Biological Process	GO:0043031	negative regulation of macrophage activation	Nr1h3	IDA		Mouse	MGI:MGI:5009771\|PMID:21187453
Biological Process	GO:0090188	negative regulation of pancreatic juice secretion	Nr1h3	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0048550	negative regulation of pinocytosis	NR1H3	IMP		Human	PMID:17693624
Biological Process	GO:0045861	negative regulation of proteolysis	Nr1h3	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	Nr1h3	IDA		Mouse	MGI:MGI:5548036\|PMID:24206663
Biological Process	GO:0090341	negative regulation of secretion of lysosomal enzymes	Nr1h3	IMP		Mouse	MGI:MGI:3822255\|PMID:18806227
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr1h3	IDA		Mouse	MGI:MGI:5009771\|PMID:21187453
Biological Process	GO:0036151	phosphatidylcholine acyl-chain remodeling	Nr1h3	IMP		Mouse	MGI:MGI:5548036\|PMID:24206663
Biological Process	GO:0010875	positive regulation of cholesterol efflux	NR1H3	IDA		Human	PMID:16141411
Biological Process	GO:0010875	positive regulation of cholesterol efflux	NR1H3	IMP		Human	PMID:17186944
Biological Process	GO:0010875	positive regulation of cholesterol efflux	NR1H3	IDA		Human	PMID:19481530
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Nr1h3	IDA		Mouse	MGI:MGI:3794353\|PMID:16825483
Biological Process	GO:0032376	positive regulation of cholesterol transport	NR1H3	IDA		Human	PMID:16141411
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NR1H3	IMP		Human	PMID:19628791
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NR1H3	IDA		Human	PMID:25661920
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr1h3	IMP		Mouse	MGI:MGI:1927704\|PMID:11090130
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	NR1H3	IMP		Human	PMID:17186944
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	NR1H3	IDA		Human	PMID:23499676
Biological Process	GO:0051006	positive regulation of lipoprotein lipase activity	NR1H3	IMP		Human	PMID:17186944
Biological Process	GO:0051247	positive regulation of protein metabolic process	NR1H3	IMP		Human	PMID:17186944
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	NR1H3	IDA		Human	PMID:18511497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:16141411
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IMP		Human	PMID:17186944
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:18511497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IMP		Human	PMID:19229075
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:19481530
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:20219900
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:20837115
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H3	IDA		Human	PMID:7744246
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h3	IDA		Mouse	MGI:MGI:4399016\|PMID:17107947
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h3	IDA		Mouse	MGI:MGI:3794353\|PMID:16825483
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h3	IDA		Mouse	MGI:MGI:5572907\|PMID:9013544
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h3	IDA		Mouse	MGI:MGI:4399022\|PMID:16141411
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	NR1H3	IMP		Human	PMID:17693624
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nr1h3	IDA		Mouse	PMID:14739254
Biological Process	GO:1904729	regulation of intestinal lipid absorption	nr1h3	IMP	ZFIN:ZDB-GENO-180725-7	Zfish	PMID:28536535
Biological Process	GO:1904729	regulation of intestinal lipid absorption	nr1h3	IMP	ZFIN:ZDB-GENO-180725-8	Zfish	PMID:28536535
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	nr1h3	IDA		Zfish	PMID:18395439
Biological Process	GO:0070723	response to cholesterol	Nr1h3	IEP		Rat	PMID:25263431\|RGD:15045610
Biological Process	GO:0031667	response to nutrient levels	Nr1h3	IEP		Rat	PMID:25263431\|RGD:15045610
Biological Process	GO:0031667	response to nutrient levels	Nr1h3	IEP		Rat	PMID:25612518\|RGD:15045599
Biological Process	GO:0032570	response to progesterone	NR1H3	IDA		Human	PMID:16141411
Biological Process	GO:0055092	sterol homeostasis	Nr1h3	IMP		Mouse	MGI:MGI:3616378\|PMID:16325781
Biological Process	GO:0070328	triglyceride homeostasis	Nr1h3	IMP		Mouse	MGI:MGI:3616378\|PMID:16325781
Biological Process	GO:0070328	triglyceride homeostasis	Nr1h3	IGI	UniProtKB:P08226	Mouse	MGI:MGI:3720271\|PMID:17657314

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.