Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR1H4
  • Mouse genes Nr1h4
  • Rat genes Nr1h4
  • Zfish genes nr1h4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr1h4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032052	bile acid binding	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Molecular Function	GO:0032052	bile acid binding	Nr1h4	IDA		Rat	PMID:12718893|RGD:1625198
Molecular Function	GO:0032052	bile acid binding	Nr1h4	IPI	CHEBI:43602	Rat	PMID:12718893|RGD:1625198
Molecular Function	GO:0032052	bile acid binding	Nr1h4	IPI	CHEBI:73676	Rat	PMID:12718893|RGD:1625198
Molecular Function	GO:0032052	bile acid binding	nr1h4	IDA		Zfish	PMID:18362391
Molecular Function	GO:0038181	bile acid receptor activity	NR1H4	IDA		Human	PMID:10334992
Molecular Function	GO:0038181	bile acid receptor activity	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Molecular Function	GO:0038181	bile acid receptor activity	Nr1h4	IDA		Rat	PMID:12718893|RGD:1625198
Molecular Function	GO:1902122	chenodeoxycholic acid binding	NR1H4	IDA		Human	PMID:10334992
Molecular Function	GO:1902122	chenodeoxycholic acid binding	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Molecular Function	GO:0003677	DNA binding	Nr1h4	IDA		Rat	PMID:11533040|RGD:70562
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NR1H4	IDA		Human	PMID:21757002
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NR1H4	IDA		Human	PMID:24211198
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NR1H4	IDA		Human	PMID:27471003
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr1h4	IDA		Mouse	PMID:27471003
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr1h4	IDA		Rat	PMID:11533040|RGD:70562
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr1h4	IGI	MGI:MGI:98214	Mouse	PMID:7760852
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NR1H4	IDA		Human	PMID:21757002
Molecular Function	GO:0003690	double-stranded DNA binding	Nr1h4	IDA		Rat	PMID:15047603|RGD:1625080
Molecular Function	GO:0004879	nuclear receptor activity	NR1H4	IDA		Human	PMID:23767959
Molecular Function	GO:0004879	nuclear receptor activity	NR1H4	IDA		Human	PMID:27471003
Molecular Function	GO:0004879	nuclear receptor activity	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Molecular Function	GO:0004879	nuclear receptor activity	Nr1h4	IDA		Mouse	PMID:27471003
Molecular Function	GO:0004879	nuclear receptor activity	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Molecular Function	GO:0004879	nuclear receptor activity	nr1h4	IDA		Zfish	PMID:18362391
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Nr1h4	IDA		Mouse	PMID:7760852
Molecular Function	GO:0042277	peptide binding	Nr1h4	IDA		Rat	PMID:12718893|RGD:1625198
Molecular Function	GO:0005515	protein binding	NR1H4	IPI	UniProtKB:Q96GM5	Human	PMID:12917342
Molecular Function	GO:0005515	protein binding	NR1H4	IPI	UniProtKB:Q15788	Human	PMID:14684751
Molecular Function	GO:0005515	protein binding	NR1H4	IPI	UniProtKB:Q15466	Human	PMID:15317749
Molecular Function	GO:0005515	protein binding	NR1H4	IPI	UniProtKB:O75151	Human	PMID:21532585
Molecular Function	GO:0005515	protein binding	NR1H4	IPI	UniProtKB:Q8WTS6	Human	PMID:22345554
Molecular Function	GO:0005515	protein binding	Nr1h4	IPI	UniProtKB:O70343-1|UniProtKB:O70343-1	Mouse	MGI:MGI:3027686|PMID:14729567
Molecular Function	GO:0044877	protein-containing complex binding	Nr1h4	IDA		Rat	PMID:11533040|RGD:70562
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NR1H4	IDA		Human	PMID:21757002
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr1h4	IDA		Rat	PMID:11533040|RGD:70562
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NR1H4	IDA		Human	PMID:23767959
Molecular Function	GO:0043565	sequence-specific DNA binding	NR1H4	IDA		Human	PMID:12815072
Molecular Function	GO:0001221	transcription coregulator binding	NR1H4	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Cellular Component	GO:0000791	euchromatin	NR1H4	IDA		Human	PMID:21757002
Cellular Component	GO:0005634	nucleus	Nr1h4	IDA		Rat	PMID:12492453|RGD:1625206
Cellular Component	GO:0005634	nucleus	Nr1h4	IDA		Rat	PMID:23331901|RGD:15042883
Cellular Component	GO:0005634	nucleus	Nr1h4	IDA		Rat	PMID:27939985|RGD:15036816
Cellular Component	GO:0043235	receptor complex	NR1H4	IDA		Human	PMID:10334992
Cellular Component	GO:0043235	receptor complex	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IMP		Rat	PMID:19136377|RGD:15042882
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IEP		Rat	PMID:27090119|RGD:15090804
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IEP		Rat	PMID:28827769|RGD:15045609
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IEP		Rat	PMID:29138817|RGD:15042871
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IDA		Rat	PMID:29235094|RGD:15042872
Biological Process	GO:0015721	bile acid and bile salt transport	Nr1h4	IMP		Rat	PMID:30068870|RGD:15042870
Biological Process	GO:0008206	bile acid metabolic process	Nr1h4	IMP	MGI:MGI:2679472	Mouse	PMID:12917447
Biological Process	GO:0008206	bile acid metabolic process	Nr1h4	IDA		Rat	PMID:12754200|RGD:1625079
Biological Process	GO:0008206	bile acid metabolic process	Nr1h4	IMP		Rat	PMID:27993716|RGD:14701034
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IMP		Rat	PMID:19136377|RGD:15042882
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IEP		Rat	PMID:27090119|RGD:15090804
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IEP		Rat	PMID:29138817|RGD:15042871
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IDA		Rat	PMID:29235094|RGD:15042872
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IEP		Rat	PMID:30061734|RGD:15092071
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IMP		Rat	PMID:30068870|RGD:15042870
Biological Process	GO:0038183	bile acid signaling pathway	Nr1h4	IEP		Rat	PMID:30223280|RGD:15045612
Biological Process	GO:0007043	cell-cell junction assembly	Nr1h4	IMP		Mouse	MGI:MGI:3620334|PMID:16473946
Biological Process	GO:1903413	cellular response to bile acid	NR1H4	IDA		Human	PMID:10334992
Biological Process	GO:1903413	cellular response to bile acid	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Biological Process	GO:0071398	cellular response to fatty acid	NR1H4	IDA		Human	PMID:20447400
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0071417	cellular response to organonitrogen compound	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Nr1h4	IEP		Rat	PMID:27090119|RGD:15090804
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Nr1h4	IDA		Rat	PMID:29235094|RGD:15042872
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h4	IMP		Mouse	MGI:MGI:2449876|PMID:12421815
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h4	IMP		Rat	PMID:19136377|RGD:15042882
Biological Process	GO:0042632	cholesterol homeostasis	Nr1h4	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0042742	defense response to bacterium	Nr1h4	IDA		Mouse	MGI:MGI:3620334|PMID:16473946
Biological Process	GO:0048565	digestive tract development	Nr1h4	IEP		Rat	PMID:11984532|RGD:1625207
Biological Process	GO:0055089	fatty acid homeostasis	Nr1h4	IMP		Mouse	MGI:MGI:3622042|PMID:16557297
Biological Process	GO:0042593	glucose homeostasis	Nr1h4	IDA		Mouse	MGI:MGI:3027686|PMID:14729567
Biological Process	GO:0042593	glucose homeostasis	Nr1h4	IEP		Rat	PMID:28946907|RGD:14928331
Biological Process	GO:0072574	hepatocyte proliferation	Nr1h4	IEP		Rat	PMID:29138817|RGD:15042871
Biological Process	GO:0038185	intracellular bile acid receptor signaling pathway	NR1H4	IDA		Human	PMID:10334992
Biological Process	GO:0038185	intracellular bile acid receptor signaling pathway	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Biological Process	GO:0001678	intracellular glucose homeostasis	Nr1h4	IDA		Mouse	MGI:MGI:3640632|PMID:16446356
Biological Process	GO:0030522	intracellular receptor signaling pathway	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0035356	intracellular triglyceride homeostasis	NR1H4	IDA		Human	PMID:20447400
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Nr1h4	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0010876	lipid localization	Nr1h4	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0097421	liver regeneration	Nr1h4	IEP		Rat	PMID:29138817|RGD:15042871
Biological Process	GO:0043066	negative regulation of apoptotic process	NR1H4	IDA		Human	PMID:20447400
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Nr1h4	IMP		Rat	PMID:15980055|RGD:1625201
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	NR1H4	IDA		Human	PMID:21242261
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0050728	negative regulation of inflammatory response	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0032692	negative regulation of interleukin-1 production	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Nr1h4	IDA		Mouse	MGI:MGI:5708041|PMID:21242261
Biological Process	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr1h4	IMP		Rat	PMID:15860571|RGD:1600916
Biological Process	GO:0010868	negative regulation of triglyceride biosynthetic process	Nr1h4	IMP		Rat	PMID:29148806|RGD:15042869
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	NR1H4	IDA		Human	PMID:21242261
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0032689	negative regulation of type II interferon production	NR1H4	IDA		Human	PMID:21242261
Biological Process	GO:0032689	negative regulation of type II interferon production	Nr1h4	IMP		Mouse	MGI:MGI:5707586|PMID:18972444
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	NR1H4	IDA		Human	PMID:27471003
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	Nr1h4	IDA		Mouse	PMID:27471003
Biological Process	GO:0007219	Notch signaling pathway	Nr1h4	IDA		Mouse	PMID:25446530
Biological Process	GO:1904179	positive regulation of adipose tissue development	Nr1h4	IMP		Mouse	MGI:MGI:3640632|PMID:16446356
Biological Process	GO:2001250	positive regulation of ammonia assimilation cycle	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NR1H4	IDA		Human	PMID:27471003
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr1h4	IDA		Mouse	PMID:27471003
Biological Process	GO:0010628	positive regulation of gene expression	Nr1h4	IMP		Rat	PMID:27993716|RGD:14701034
Biological Process	GO:0010628	positive regulation of gene expression	Nr1h4	IMP		Rat	PMID:29148806|RGD:15042869
Biological Process	GO:2000213	positive regulation of glutamate metabolic process	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Nr1h4	IDA		Mouse	MGI:MGI:3640632|PMID:16446356
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Nr1h4	IMP		Mouse	MGI:MGI:4457989|PMID:20447400
Biological Process	GO:0032740	positive regulation of interleukin-17 production	NR1H4	IDA		Human	PMID:21242261
Biological Process	GO:1905695	positive regulation of phosphatidic acid biosynthetic process	NR1H4	IDA		Human	PMID:23767959
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H4	IMP		Human	PMID:21757002
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR1H4	IDA		Human	PMID:23767959
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h4	IDA		Mouse	PMID:24211198
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h4	IDA		Rat	PMID:11533040|RGD:70562
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr1h4	IMP		Rat	PMID:17065154|RGD:1625199
Biological Process	GO:0120188	regulation of bile acid secretion	Nr1h4	IEP		Rat	PMID:27090119|RGD:15090804
Biological Process	GO:0006109	regulation of carbohydrate metabolic process	Nr1h4	IMP		Rat	PMID:15564327|RGD:1625077
Biological Process	GO:0006355	regulation of DNA-templated transcription	nr1h4	IDA		Zfish	PMID:18362391
Biological Process	GO:0010468	regulation of gene expression	Nr1h4	IMP		Rat	PMID:15980055|RGD:1625201
Biological Process	GO:0010468	regulation of gene expression	Nr1h4	IEP		Rat	PMID:27090119|RGD:15090804
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	NR1H4	IDA		Human	PMID:20447400
Biological Process	GO:0010883	regulation of lipid storage	Nr1h4	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0010988	regulation of low-density lipoprotein particle clearance	NR1H4	IDA		Human	PMID:12660231
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	NR1H4	IDA		Human	PMID:10334992
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nr1h4	IGI	MGI:MGI:98214	Mouse	PMID:7760852
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Nr1h4	IDA		Rat	PMID:10334992|RGD:15090836
Biological Process	GO:0034255	regulation of urea metabolic process	Nr1h4	IMP		Mouse	MGI:MGI:5306122|PMID:21757002
Biological Process	GO:0070723	response to cholesterol	Nr1h4	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0043627	response to estrogen	Nr1h4	IEP		Rat	PMID:27090119|RGD:15090804
Biological Process	GO:0045471	response to ethanol	Nr1h4	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:1901557	response to fenofibrate	Nr1h4	IEP		Rat	PMID:30257410|RGD:15090799
Biological Process	GO:0009749	response to glucose	Nr1h4	IEP		Rat	PMID:15047603|RGD:1625080
Biological Process	GO:0032496	response to lipopolysaccharide	Nr1h4	IEP		Rat	PMID:12492453|RGD:1625206
Biological Process	GO:0071873	response to norepinephrine	Nr1h4	IMP		Rat	PMID:19418582|RGD:15042868
Biological Process	GO:0031667	response to nutrient levels	Nr1h4	IEP		Rat	PMID:23117815|RGD:15045604
Biological Process	GO:0031667	response to nutrient levels	Nr1h4	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0031667	response to nutrient levels	Nr1h4	IEP		Rat	PMID:25612518|RGD:15045599
Biological Process	GO:0031667	response to nutrient levels	Nr1h4	IEP		Rat	PMID:30257410|RGD:15090799
Biological Process	GO:0014070	response to organic cyclic compound	Nr1h4	IEP		Rat	PMID:27939985|RGD:15036816
Biological Process	GO:0009410	response to xenobiotic stimulus	Nr1h4	IEP		Rat	PMID:29091898|RGD:15090820
Biological Process	GO:0009410	response to xenobiotic stimulus	Nr1h4	IEP		Rat	PMID:30308196|RGD:15042865
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	NR1H4	IDA		Human	PMID:19864602
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	Nr1h4	IMP		Mouse	MGI:MGI:5486235|PMID:23372731
Biological Process	GO:0006366	transcription by RNA polymerase II	Nr1h4	IDA		Mouse	PMID:24211198
Biological Process	GO:0070328	triglyceride homeostasis	Nr1h4	IDA		Mouse	MGI:MGI:5706917|PMID:12891557
Biological Process	GO:0070328	triglyceride homeostasis	Nr1h4	IMP		Rat	PMID:19136377|RGD:15042882
Biological Process	GO:0070328	triglyceride homeostasis	Nr1h4	IEP		Rat	PMID:23117815|RGD:15045604

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern