Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR2E1
  • Mouse genes Nr2e1
  • Rat genes Nr2e1
  • Zfish genes nr2e1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr2e1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr2e1	IDA		Mouse	PMID:19555662
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nr2e1	IDA		Mouse	PMID:14702088
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:10706625
Molecular Function	GO:0019899	enzyme binding	Nr2e1	IPI	UniProtKB:Q6ZQ88	Mouse	MGI:MGI:4461095|PMID:20123967
Molecular Function	GO:0042826	histone deacetylase binding	Nr2e1	IPI	UniProtKB:Q9Z2V6	Mouse	MGI:MGI:4461095|PMID:20123967
Molecular Function	GO:0005515	protein binding	Nr2e1	IPI	UniProtKB:O88895|UniProtKB:Q9Z2V6	Mouse	MGI:MGI:6092585|PMID:17873065
Molecular Function	GO:0005515	protein binding	Nr2e1	IPI	PR:O35126	Mouse	PMID:16702404
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr2e1	IDA		Mouse	PMID:16702404
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR2E1	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Nr2e1	IDA		Mouse	PMID:17901127
Biological Process	GO:0002118	aggressive behavior	Nr2e1	IMP	MGI:MGI:2181426,MGI:MGI:3764730	Mouse	PMID:17953618
Biological Process	GO:0002118	aggressive behavior	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:14994267
Biological Process	GO:0002118	aggressive behavior	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0002118	aggressive behavior	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:16000615
Biological Process	GO:0021764	amygdala development	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0001525	angiogenesis	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16424942
Biological Process	GO:0021960	anterior commissure morphogenesis	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:11997145
Biological Process	GO:0006915	apoptotic process	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0043615	astrocyte cell migration	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:15371513
Biological Process	GO:0048708	astrocyte differentiation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:0001662	behavioral fear response	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0007420	brain development	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:14994267
Biological Process	GO:0043010	camera-type eye development	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:15371513
Biological Process	GO:0043010	camera-type eye development	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:16000615
Biological Process	GO:0007049	cell cycle	Nr2e1	IMP		Mouse	PMID:17901127
Biological Process	GO:0045165	cell fate commitment	Nr2e1	IGI	MGI:MGI:97490	Mouse	PMID:15229646
Biological Process	GO:0008283	cell population proliferation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:0008283	cell population proliferation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0021987	cerebral cortex development	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:11997145
Biological Process	GO:0021987	cerebral cortex development	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:16000615
Biological Process	GO:0021987	cerebral cortex development	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0021987	cerebral cortex development	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:15950290
Biological Process	GO:0021895	cerebral cortex neuron differentiation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12902391
Biological Process	GO:0021895	cerebral cortex neuron differentiation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:15950290
Biological Process	GO:0021542	dentate gyrus development	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0021542	dentate gyrus development	Nr2e1	IMP	MGI:MGI:2181426	Mouse	PMID:17953618
Biological Process	GO:0030198	extracellular matrix organization	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16424942
Biological Process	GO:0021872	forebrain generation of neurons	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:9394001
Biological Process	GO:0021819	layer formation in cerebral cortex	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:15385616
Biological Process	GO:0060291	long-term synaptic potentiation	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:16289828
Biological Process	GO:0043066	negative regulation of apoptotic process	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:15385616
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0045665	negative regulation of neuron differentiation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0045665	negative regulation of neuron differentiation	Nr2e1	IMP		Mouse	PMID:17901127
Biological Process	GO:0045665	negative regulation of neuron differentiation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0045665	negative regulation of neuron differentiation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr2e1	IMP		Mouse	MGI:MGI:4461095|PMID:20123967
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr2e1	IDA		Mouse	PMID:14702088
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:10706625
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nr2e1	IDA		Mouse	PMID:16702404
Biological Process	GO:0061351	neural precursor cell proliferation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0061351	neural precursor cell proliferation	Nr2e1	IMP		Mouse	MGI:MGI:61253
Biological Process	GO:0061351	neural precursor cell proliferation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:15385616
Biological Process	GO:0007405	neuroblast proliferation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0030182	neuron differentiation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:0030182	neuron differentiation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0030182	neuron differentiation	Nr2e1	IMP		Mouse	PMID:17901127
Biological Process	GO:0021772	olfactory bulb development	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0021772	olfactory bulb development	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:11997145
Biological Process	GO:0045766	positive regulation of angiogenesis	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16424942
Biological Process	GO:0045787	positive regulation of cell cycle	Nr2e1	IMP		Mouse	PMID:17901127
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Nr2e1	IMP		Mouse	MGI:MGI:4461095|PMID:20123967
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Nr2e1	IMP		Mouse	MGI:MGI:61253
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Nr2e1	IMP		Mouse	MGI:MGI:4461095|PMID:20123967
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16424942
Biological Process	GO:0051128	regulation of cellular component organization	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16424942
Biological Process	GO:0048814	regulation of dendrite morphogenesis	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:16289828
Biological Process	GO:0060164	regulation of timing of neuron differentiation	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:15385616
Biological Process	GO:0060041	retina development in camera-type eye	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:11997145
Biological Process	GO:0060041	retina development in camera-type eye	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0035176	social behavior	Nr2e1	IMP	MGI:MGI:2176490	Mouse	PMID:11997145
Biological Process	GO:0035019	somatic stem cell population maintenance	Nr2e1	IMP	MGI:MGI:3764730,MGI:MGI:3807544	Mouse	PMID:18794344
Biological Process	GO:0035019	somatic stem cell population maintenance	Nr2e1	IMP	MGI:MGI:2151350	Mouse	PMID:12527005
Biological Process	GO:0035019	somatic stem cell population maintenance	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:14702088
Biological Process	GO:0007601	visual perception	Nr2e1	IMP	MGI:MGI:2176560	Mouse	PMID:16702404
Biological Process	GO:0007601	visual perception	Nr2e1	IMP		Mouse	PMID:10706625

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern