Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR3C2
  • Mouse genes Nr3c2
  • Rat genes Nr3c2
  • Zfish genes nr3c2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr3c2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Nr3c2	IMP		Rat	PMID:8618925|RGD:1601060
Molecular Function	GO:0003690	double-stranded DNA binding	Nr3c2	IDA		Rat	PMID:8618925|RGD:1601060
Molecular Function	GO:0035035	histone acetyltransferase binding	Nr3c2	IPI	RGD:1348463	Rat	PMID:10847590|RGD:152975666
Molecular Function	GO:0042802	identical protein binding	Nr3c2	IPI	RGD:3094	Rat	PMID:8618925|RGD:1601060
Molecular Function	GO:0003707	nuclear steroid receptor activity	Nr3c2	IMP		Rat	PMID:17260968|RGD:1600931
Molecular Function	GO:0003707	nuclear steroid receptor activity	nr3c2	IDA		Zfish	PMID:20932876
Molecular Function	GO:0005515	protein binding	NR3C2	IPI	UniProtKB:P48552	Human	PMID:11518808
Molecular Function	GO:0005515	protein binding	Nr3c2	IPI	PR:P11499	Mouse	PMID:11809749
Molecular Function	GO:0005515	protein binding	Nr3c2	IPI	UniProtKB:P84022	Rat	PMID:12902338|RGD:12793020
Molecular Function	GO:0044877	protein-containing complex binding	Nr3c2	IDA		Rat	PMID:8618925|RGD:1601060
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr3c2	IDA		Rat	PMID:8618925|RGD:1601060
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr3c2	IDA		Rat	PMID:8690788|RGD:1601056
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR3C2	IDA		Human	PMID:28473536
Molecular Function	GO:0005496	steroid binding	Nr3c2	IDA		Mouse	PMID:11809749
Molecular Function	GO:0005496	steroid binding	Nr3c2	IMP		Rat	PMID:17260968|RGD:1600931
Molecular Function	GO:1990239	steroid hormone binding	nr3c2	IDA		Zfish	PMID:29970600
Molecular Function	GO:0001223	transcription coactivator binding	Nr3c2	IPI	RGD:732737	Rat	PMID:10847590|RGD:152975666
Cellular Component	GO:0005737	cytoplasm	Nr3c2	IDA		Rat	PMID:16188378|RGD:1601051
Cellular Component	GO:0005737	cytoplasm	Nr3c2	IDA		Rat	PMID:17260968|RGD:1600931
Cellular Component	GO:0098982	GABA-ergic synapse	Nr3c2	EXP		Mouse	PMID:18547242
Cellular Component	GO:0098982	GABA-ergic synapse	Nr3c2	IDA		Mouse	PMID:18547242
Cellular Component	GO:0098978	glutamatergic synapse	Nr3c2	IDA		Mouse	PMID:18547242
Cellular Component	GO:0098978	glutamatergic synapse	Nr3c2	EXP		Mouse	PMID:18547242
Cellular Component	GO:0098978	glutamatergic synapse	Nr3c2	IDA		Rat	PMID:21179518|RGD:4892203
Cellular Component	GO:0005654	nucleoplasm	NR3C2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nr3c2	IDA		Rat	PMID:16188378|RGD:1601051
Cellular Component	GO:0005634	nucleus	Nr3c2	IDA		Rat	PMID:17260968|RGD:1600931
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Nr3c2	IDA		Rat	PMID:21179518|RGD:4892203
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Nr3c2	IDA		Rat	PMID:21179518|RGD:4892203
Cellular Component	GO:0043235	receptor complex	NR3C2	IDA		Human	PMID:23382219
Biological Process	GO:0038166	angiotensin-activated signaling pathway	Nr3c2	IMP		Mouse	PMID:24206662
Biological Process	GO:1904045	cellular response to aldosterone	Nr3c2	IMP		Rat	PMID:10847590|RGD:152975666
Biological Process	GO:0071387	cellular response to cortisol stimulus	nr3c2	IMP	ZFIN:ZDB-GENO-200928-2	Zfish	PMID:31246274
Biological Process	GO:0006883	intracellular sodium ion homeostasis	Nr3c2	IMP	MGI:MGI:2441654	Mouse	PMID:9689096
Biological Process	GO:0033555	multicellular organismal response to stress	nr3c2	IEP		Zfish	PMID:25748166
Biological Process	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	nr3c2	IGI	ZFIN:ZDB-GENO-210727-10,ZFIN:ZDB-CRISPR-201102-9,ZFIN:ZDB-CRISPR-201102-10,ZFIN:ZDB-CRISPR-201102-11,ZFIN:ZDB-CRISPR-201102-12	Zfish	PMID:32379754
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NR3C2	IMP		Human	PMID:30769772
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr3c2	IMP		Rat	PMID:10847590|RGD:152975666
Biological Process	GO:0055075	potassium ion homeostasis	Nr3c2	IMP		Mouse	PMID:24206662
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Nr3c2	IDA		Mouse	PMID:18547242
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Nr3c2	EXP		Mouse	PMID:18547242
Biological Process	GO:0002017	regulation of blood volume by renal aldosterone	Nr3c2	IMP		Mouse	PMID:24206662
Biological Process	GO:0042127	regulation of cell population proliferation	Nr3c2	IDA		Rat	PMID:16115202|RGD:1601054
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Nr3c2	IDA		Mouse	PMID:18547242
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	Nr3c2	EXP		Mouse	PMID:18547242
Biological Process	GO:1904451	regulation of potassium:proton exchanging ATPase activity	Nr3c2	IDA		Mouse	PMID:24206662
Biological Process	GO:0035812	renal sodium excretion	Nr3c2	IMP	MGI:MGI:2441654	Mouse	PMID:9689096
Biological Process	GO:0048545	response to steroid hormone	nr3c2	IDA		Zfish	PMID:29970600
Biological Process	GO:0007165	signal transduction	Nr3c2	IMP		Mouse	PMID:24206662

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern