Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR4A1
  • Mouse genes Nr4a1
  • Rat genes Nr4a1
  • Zfish genes nr4a1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr4a1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Nr4a1	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr4a1	IDA		Mouse	PMID:9155013
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr4a1	IDA		Rat	PMID:10523643|RGD:10054079
Molecular Function	GO:0042802	identical protein binding	Nr4a1	IPI	PR:P12813	Mouse	PMID:18388149
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	Nr4a1	IPI	UniProtKB:P04150	Rat	PMID:15591535|RGD:10047331
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P04637	Human	PMID:17139261
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P03120	Human	PMID:18305892
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P10415	Human	PMID:18835031
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:Q9WMX2:PRO_0000037545	Human	PMID:18985028
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:Q99873	Human	PMID:19095693
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:O60888	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P04350	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P43243	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P50552	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:Q9P2G1	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P32189	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P40763	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:O14980	Human	PMID:22427340
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P40305-2	Human	PMID:22427340
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P03120	Human	PMID:22761572
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:Q9Y4D7	Human	PMID:24139859
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P55273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P60370	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:Q17RB8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:Q96JS3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NR4A1	IPI	UniProtKB:P55273	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	UniProtKB:Q04207	Mouse	MGI:MGI:5927454|PMID:25822914
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	UniProtKB:Q62318|UniProtKB:Q7TPV4|UniProtKB:Q8VHR5|UniProtKB:Q9DBD5|UniProtKB:Q9R190	Mouse	MGI:MGI:5644023|PMID:19321449
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	PR:P70365	Mouse	PMID:15155786
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	PR:Q61066	Mouse	PMID:15155786
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	PR:P13405	Mouse	PMID:15701640
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	UniProtKB:O75798	Mouse	PMID:8961274
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	PR:Q06219	Mouse	PMID:10523643
Molecular Function	GO:0005515	protein binding	Nr4a1	IPI	UniProtKB:Q62318	Rat	PMID:19321449|RGD:10047236
Molecular Function	GO:0046982	protein heterodimerization activity	Nr4a1	IDA		Rat	PMID:10523643|RGD:10054079
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr4a1	IDA		Mouse	PMID:18388149
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr4a1	IDA		Mouse	PMID:8961274
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR4A1	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	NR4A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031965	nuclear membrane	NR4A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NR4A1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nr4a1	IDA		Mouse	MGI:MGI:4412441|PMID:18292087
Cellular Component	GO:0005634	nucleus	Nr4a1	IDA		Mouse	PMID:17434920
Cellular Component	GO:0005634	nucleus	Nr4a1	IDA		Mouse	PMID:12815108
Cellular Component	GO:0005634	nucleus	Nr4a1	IDA		Rat	PMID:15942958|RGD:1598733
Cellular Component	GO:0005667	transcription regulator complex	Nr4a1	IDA		Mouse	PMID:9155013
Biological Process	GO:0006915	apoptotic process	Nr4a1	IMP	MGI:MGI:2182325	Mouse	PMID:17434920
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	NR4A1	IDA		Human	PMID:18059339
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	Nr4a1	IDA		Mouse	MGI:MGI:5645213|PMID:10523643
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	NR4A1	IMP		Human	PMID:18059339
Biological Process	GO:0071310	cellular response to organic substance	Nr4a1	IDA		Mouse	PMID:21357543
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	NR4A1	IMP		Human	PMID:18059339
Biological Process	GO:0035767	endothelial cell chemotaxis	NR4A1	IMP		Human	PMID:18059339
Biological Process	GO:0045444	fat cell differentiation	Nr4a1	IDA		Mouse	MGI:MGI:5645207|PMID:18945812
Biological Process	GO:0045786	negative regulation of cell cycle	Nr4a1	IDA		Mouse	MGI:MGI:5645207|PMID:18945812
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Nr4a1	IDA		Mouse	PMID:12815108
Biological Process	GO:0014860	neurotransmitter secretion involved in regulation of skeletal muscle contraction	Nr4a1	IMP		Rat	PMID:29530712|RGD:40924655
Biological Process	GO:0043065	positive regulation of apoptotic process	Nr4a1	IDA		Mouse	PMID:14657025
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr4a1	IDA		Mouse	PMID:8961274
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr4a1	IDA		Mouse	PMID:14657025
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	NR4A1	IMP		Human	PMID:18059339
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR4A1	IDA		Human	PMID:22427340
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IGI	MGI:MGI:97874	Mouse	PMID:15701640
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IGI	MGI:MGI:1276523	Mouse	PMID:15155786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IDA		Mouse	PMID:9155013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IGI	MGI:MGI:1352460	Mouse	PMID:15155786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IMP	MGI:MGI:2182325	Mouse	PMID:28775000
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IDA		Mouse	PMID:8961274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IDA		Mouse	PMID:15155786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IGI	MGI:MGI:1339708	Mouse	PMID:15701640
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IDA		Rat	PMID:10523643|RGD:10054079
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a1	IDA		Rat	PMID:19321449|RGD:10047236
Biological Process	GO:0010906	regulation of glucose metabolic process	nr4a1	IMP	ZFIN:ZDB-GENO-230118-5	Zfish	PMID:35547009
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	Nr4a1	IMP		Rat	PMID:24706823|RGD:10054075
Biological Process	GO:0001975	response to amphetamine	Nr4a1	IMP		Rat	PMID:29530712|RGD:40924655
Biological Process	GO:0051602	response to electrical stimulus	Nr4a1	IEP		Rat	PMID:9630512|RGD:14700867
Biological Process	GO:0032496	response to lipopolysaccharide	Nr4a1	IEP		Rat	PMID:8821744|RGD:14700868
Biological Process	GO:0035914	skeletal muscle cell differentiation	Nr4a1	IMP		Mouse	PMID:22147266
Biological Process	GO:0006366	transcription by RNA polymerase II	Nr4a1	IGI	MGI:MGI:1352460	Mouse	PMID:15155786
Biological Process	GO:0006366	transcription by RNA polymerase II	Nr4a1	IGI	MGI:MGI:1276523	Mouse	PMID:15155786

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern