Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR4A2
  • Mouse genes Nr4a2
  • Rat genes Nr4a2
  • Zfish genes nr4a2a,nr4a2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr4a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Nr4a2	IDA		Mouse	PMID:14671317
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr4a2	IMP		Mouse	MGI:MGI:5572894|PMID:12122012
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr4a2	IDA		Mouse	MGI:MGI:5645213|PMID:10523643
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr4a2	IDA		Mouse	MGI:MGI:5572894|PMID:12122012
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr4a2	IDA		Rat	PMID:8737662|RGD:8553440
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	Nr4a2	IPI	UniProtKB:P04150	Mouse	MGI:MGI:5644026|PMID:15591535
Molecular Function	GO:0005515	protein binding	NR4A2	IPI	UniProtKB:Q5H9L2	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	NR4A2	IPI	UniProtKB:P55273	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	NR4A2	IPI	UniProtKB:P55273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR4A2	IPI	UniProtKB:Q5T2S8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NR4A2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	UniProtKB:Q04207|UniProtKB:Q8CFE3	Mouse	MGI:MGI:3850810|PMID:19345186
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	UniProtKB:O54943	Mouse	MGI:MGI:4429726|PMID:20159955
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	UniProtKB:Q62318	Mouse	MGI:MGI:5644023|PMID:19321449
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	UniProtKB:O09106|UniProtKB:Q60520|UniProtKB:Q8VIJ6|UniProtKB:Q9WU42	Mouse	MGI:MGI:3830409|PMID:19144721
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	PR:P49919	Mouse	PMID:14671317
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	PR:P63017	Mouse	PMID:18346207
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	PR:Q8BPQ7	Mouse	PMID:18784308
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	PR:P12813	Mouse	PMID:10523643
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	UniProtKB:O75798	Mouse	PMID:8961274
Molecular Function	GO:0005515	protein binding	Nr4a2	IPI	PR:P28700	Mouse	PMID:18784308
Molecular Function	GO:0046982	protein heterodimerization activity	Nr4a2	IDA		Mouse	MGI:MGI:5645213|PMID:10523643
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr4a2	IDA		Mouse	PMID:19515692
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr4a2	IDA		Rat	PMID:8737662|RGD:8553440
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nr4a2	IMP		Mouse	MGI:MGI:5572894|PMID:12122012
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr4a2	IDA		Mouse	PMID:8961274
Molecular Function	GO:0043565	sequence-specific DNA binding	Nr4a2	IDA		Rat	PMID:8737662|RGD:8553440
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR4A2	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	Nr4a2	IDA		Rat	PMID:28743636|RGD:126775142
Cellular Component	GO:0000785	chromatin	Nr4a2	IDA		Rat	PMID:32451509|RGD:124713569
Cellular Component	GO:0005737	cytoplasm	Nr4a2	IDA		Rat	PMID:12929136|RGD:1358551
Cellular Component	GO:0016607	nuclear speck	NR4A2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NR4A2	IDA		Human	PMID:17184956
Cellular Component	GO:0005634	nucleus	NR4A2	IDA		Human	PMID:24399192
Cellular Component	GO:0005634	nucleus	Nr4a2	IDA		Mouse	PMID:11749040
Cellular Component	GO:0005634	nucleus	Nr4a2	IDA		Mouse	PMID:18388149
Cellular Component	GO:0005634	nucleus	Nr4a2	IDA		Rat	PMID:12929136|RGD:1358551
Biological Process	GO:0008344	adult locomotory behavior	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:12385813
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	Nr4a2	IDA		Mouse	MGI:MGI:5645213|PMID:10523643
Biological Process	GO:0031668	cellular response to extracellular stimulus	NR4A2	IDA		Human	PMID:7877627
Biological Process	GO:0031668	cellular response to extracellular stimulus	Nr4a2	IDA		Mouse	PMID:8961274
Biological Process	GO:0034599	cellular response to oxidative stress	Nr4a2	IMP		Mouse	PMID:20566846
Biological Process	GO:0021954	central nervous system neuron development	nr4a2a	IMP	ZFIN:ZDB-MRPHLNO-080509-1	Zfish	PMID:18053265
Biological Process	GO:0021953	central nervous system neuron differentiation	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:11113533
Biological Process	GO:0021953	central nervous system neuron differentiation	nr4a2b	IMP	ZFIN:ZDB-MRPHLNO-090630-12	Zfish	PMID:18822380
Biological Process	GO:0021953	central nervous system neuron differentiation	nr4a2a	IGI	ZFIN:ZDB-MRPHLNO-090209-1	Zfish	PMID:18822380
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:10585298
Biological Process	GO:0021987	cerebral cortex development	Nr4a2	IEP		Rat	PMID:21056632|RGD:124713572
Biological Process	GO:0006351	DNA-templated transcription	NR4A2	IDA		Human	PMID:17184956
Biological Process	GO:0006351	DNA-templated transcription	Nr4a2	IDA		Mouse	MGI:MGI:3830409|PMID:19144721
Biological Process	GO:0042416	dopamine biosynthetic process	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:9608532
Biological Process	GO:0042416	dopamine biosynthetic process	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:16782508
Biological Process	GO:0042417	dopamine metabolic process	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:12385813
Biological Process	GO:0071542	dopaminergic neuron differentiation	Nr4a2	IDA		Mouse	MGI:MGI:3830409|PMID:19144721
Biological Process	GO:0071542	dopaminergic neuron differentiation	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:11113533
Biological Process	GO:0071542	dopaminergic neuron differentiation	Nr4a2	IMP	MGI:MGI:3043985	Mouse	PMID:14622207
Biological Process	GO:0071542	dopaminergic neuron differentiation	Nr4a2	IMP	MGI:MGI:3043985	Mouse	PMID:9520484
Biological Process	GO:0071542	dopaminergic neuron differentiation	nr4a2b	IGI	ZFIN:ZDB-MRPHLNO-090209-1	Zfish	PMID:22898306
Biological Process	GO:0071542	dopaminergic neuron differentiation	nr4a2a	IGI	ZFIN:ZDB-MRPHLNO-090209-1	Zfish	PMID:22898306
Biological Process	GO:0045444	fat cell differentiation	Nr4a2	IDA		Mouse	MGI:MGI:5645207|PMID:18945812
Biological Process	GO:0021884	forebrain neuron development	nr4a2b	IMP	ZFIN:ZDB-MRPHLNO-080509-2	Zfish	PMID:18638558
Biological Process	GO:0021884	forebrain neuron development	nr4a2a	IMP	ZFIN:ZDB-MRPHLNO-080509-3	Zfish	PMID:18638558
Biological Process	GO:0010467	gene expression	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:10465447
Biological Process	GO:0051866	general adaptation syndrome	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:12385813
Biological Process	GO:0021986	habenula development	Nr4a2	IMP		Mouse	PMID:19906978
Biological Process	GO:0007611	learning or memory	Nr4a2	IMP		Rat	PMID:17142303|RGD:124713573
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	NR4A2	IMP		Human	PMID:19429166
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Nr4a2	IMP		Mouse	PMID:20566846
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:10585298
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Nr4a2	IMP		Rat	PMID:22294685|RGD:124713574
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NR4A2	IMP		Human	PMID:18463503
Biological Process	GO:0007399	nervous system development	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:11749040
Biological Process	GO:0007399	nervous system development	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:9092472
Biological Process	GO:0051402	neuron apoptotic process	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:10585298
Biological Process	GO:0051402	neuron apoptotic process	Nr4a2	IMP		Mouse	PMID:20566846
Biological Process	GO:0030182	neuron differentiation	Nr4a2	IMP	MGI:MGI:3043985	Mouse	PMID:9520484
Biological Process	GO:0030182	neuron differentiation	Nr4a2	IMP	MGI:MGI:3043985	Mouse	PMID:14622207
Biological Process	GO:0042551	neuron maturation	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:10585298
Biological Process	GO:0001764	neuron migration	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:10585298
Biological Process	GO:0001780	neutrophil homeostasis	nr4a2b	IGI	ZFIN:ZDB-MRPHLNO-090209-1	Zfish	PMID:28637666
Biological Process	GO:0001780	neutrophil homeostasis	nr4a2a	IGI	ZFIN:ZDB-MRPHLNO-090209-1	Zfish	PMID:28637666
Biological Process	GO:0043085	positive regulation of catalytic activity	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:11517332
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr4a2	IDA		Mouse	PMID:8961274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Mouse	MGI:MGI:5572894|PMID:12122012
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Mouse	MGI:MGI:5644023|PMID:19321449
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Mouse	MGI:MGI:5645213|PMID:10523643
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IGI	MGI:MGI:1352460	Mouse	PMID:15155786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Mouse	PMID:15155786
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Mouse	PMID:17394463
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:16782508
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Mouse	PMID:14671317
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr4a2	IDA		Rat	PMID:8737662|RGD:8553440
Biological Process	GO:0009791	post-embryonic development	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:9608532
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:19906978
Biological Process	GO:0042053	regulation of dopamine metabolic process	Nr4a2	IDA		Mouse	PMID:12915123
Biological Process	GO:0010468	regulation of gene expression	Nr4a2	IMP		Mouse	PMID:19515692
Biological Process	GO:0043576	regulation of respiratory gaseous exchange	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:14742729
Biological Process	GO:0001975	response to amphetamine	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:12385813
Biological Process	GO:0001666	response to hypoxia	Nr4a2	IMP	MGI:MGI:2157566	Mouse	PMID:14742729
Biological Process	GO:0010035	response to inorganic substance	Nr4a2	IDA		Rat	PMID:1491694|RGD:8553348
Biological Process	GO:0017085	response to insecticide	Nr4a2	IDA		Rat	PMID:8737662|RGD:8553440
Biological Process	GO:0060041	retina development in camera-type eye	Nr4a2	IEP		Rat	PMID:22714110|RGD:124713571
Biological Process	GO:0006366	transcription by RNA polymerase II	Nr4a2	IMP	MGI:MGI:2429971	Mouse	PMID:16782508

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern