Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NR5A2
  • Mouse genes Nr5a2
  • Rat genes Nr5a2
  • Zfish genes nr5a2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr5a2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nr5a2	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0003677	DNA binding	NR5A2	IDA		Human	PMID:16289203
Molecular Function	GO:0003677	DNA binding	Nr5a2	IDA		Mouse	PMID:15014077
Molecular Function	GO:0003677	DNA binding	Nr5a2	IDA		Mouse	PMID:16912278
Molecular Function	GO:0003677	DNA binding	nr5a2	IDA		Zfish	PMID:14517294
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Nr5a2	IDA		Mouse	MGI:MGI:2662795|PMID:12456679
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NR5A2	IDA		Human	PMID:15205472
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NR5A2	IDA		Human	PMID:15723037
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NR5A2	IDA		Human	PMID:16289203
Molecular Function	GO:0003700	DNA-binding transcription factor activity	nr5a2	IDA		Zfish	PMID:14517294
Molecular Function	GO:0003690	double-stranded DNA binding	Nr5a2	IDA		Rat	PMID:8668203|RGD:68248
Molecular Function	GO:0004879	nuclear receptor activity	NR5A2	IDA		Human	PMID:15205472
Molecular Function	GO:0004879	nuclear receptor activity	Nr5a2	IDA		Rat	PMID:8668203|RGD:68248
Molecular Function	GO:0005543	phospholipid binding	NR5A2	IDA		Human	PMID:15723037
Molecular Function	GO:0005515	protein binding	NR5A2	IPI	UniProtKB:O60869	Human	PMID:12040021
Molecular Function	GO:0005515	protein binding	NR5A2	IPI	UniProtKB:Q92786	Human	PMID:15143342
Molecular Function	GO:0005515	protein binding	NR5A2	IPI	UniProtKB:Q92786	Human	PMID:15205472
Molecular Function	GO:0005515	protein binding	NR5A2	IPI	UniProtKB:Q92830	Human	PMID:17664281
Molecular Function	GO:0005515	protein binding	NR5A2	IPI	UniProtKB:Q92786	Human	PMID:19264593
Molecular Function	GO:0005515	protein binding	nr5a2	IPI	ZFIN:ZDB-GENE-980526-362,ZFIN:ZDB-GENE-990415-79	Zfish	PMID:28642062
Molecular Function	GO:0005515	protein binding	nr5a2	IPI	ZFIN:ZDB-GENE-040426-2575,ZFIN:ZDB-GENE-990415-79	Zfish	PMID:28642062
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a2	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a2	IDA		Mouse	MGI:MGI:2662795|PMID:12456679
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nr5a2	IDA		Mouse	PMID:15831456
Molecular Function	GO:0043565	sequence-specific DNA binding	NR5A2	IDA		Human	PMID:16289203
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	NR5A2	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	NR5A2	IDA		Human	PMID:15205472
Molecular Function	GO:0001221	transcription coregulator binding	NR5A2	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Cellular Component	GO:0005737	cytoplasm	NR5A2	IDA		Human	PMID:15205472
Cellular Component	GO:0005634	nucleus	NR5A2	IDA		Human	PMID:15143342
Cellular Component	GO:0005634	nucleus	NR5A2	IDA		Human	PMID:15205472
Cellular Component	GO:0005634	nucleus	Nr5a2	IDA		Mouse	PMID:19796622
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	Nr5a2	IDA		Mouse	MGI:MGI:5644022|PMID:19389484
Biological Process	GO:0090425	acinar cell differentiation	Nr5a2	IMP		Mouse	PMID:25063451
Biological Process	GO:0008206	bile acid metabolic process	Nr5a2	IMP	MGI:MGI:3050234	Mouse	PMID:15014077
Biological Process	GO:0097720	calcineurin-mediated signaling	Nr5a2	IMP		Rat	PMID:25057110|RGD:12904895
Biological Process	GO:0051216	cartilage development	nr5a2	IMP	ZFIN:ZDB-MRPHLNO-051025-2	Zfish	PMID:18950725
Biological Process	GO:0051216	cartilage development	nr5a2	IMP	ZFIN:ZDB-MRPHLNO-100428-2	Zfish	PMID:18950725
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Nr5a2	IEP		Mouse	PMID:20439489
Biological Process	GO:0042632	cholesterol homeostasis	Nr5a2	IMP	MGI:MGI:3050234	Mouse	PMID:15014077
Biological Process	GO:0048565	digestive tract development	nr5a2	IMP	ZFIN:ZDB-GENO-180322-2	Zfish	PMID:28642062
Biological Process	GO:0048565	digestive tract development	nr5a2	IMP	ZFIN:ZDB-GENO-180322-3	Zfish	PMID:28642062
Biological Process	GO:0048565	digestive tract development	nr5a2	IMP	ZFIN:ZDB-MRPHLNO-051025-2	Zfish	PMID:28642062
Biological Process	GO:0031017	exocrine pancreas development	nr5a2	IMP	ZFIN:ZDB-GENO-170124-4	Zfish	PMID:27474396
Biological Process	GO:0031017	exocrine pancreas development	nr5a2	IMP	ZFIN:ZDB-GENO-180322-2	Zfish	PMID:28642062
Biological Process	GO:0031017	exocrine pancreas development	nr5a2	IMP	ZFIN:ZDB-MRPHLNO-051025-2	Zfish	PMID:28642062
Biological Process	GO:0031017	exocrine pancreas development	nr5a2	IMP	ZFIN:ZDB-GENO-180322-3	Zfish	PMID:28642062
Biological Process	GO:0061017	hepatoblast differentiation	nr5a2	IMP	ZFIN:ZDB-GENO-170124-4	Zfish	PMID:27474396
Biological Process	GO:0001889	liver development	nr5a2	IMP	ZFIN:ZDB-MRPHLNO-051025-2	Zfish	PMID:28642062
Biological Process	GO:0001889	liver development	nr5a2	IMP	ZFIN:ZDB-GENO-170124-4	Zfish	PMID:27474396
Biological Process	GO:0001889	liver development	nr5a2	IMP	ZFIN:ZDB-GENO-180322-3	Zfish	PMID:28642062
Biological Process	GO:0001889	liver development	nr5a2	IMP	ZFIN:ZDB-GENO-180322-2	Zfish	PMID:28642062
Biological Process	GO:0061113	pancreas morphogenesis	Nr5a2	IMP		Mouse	PMID:25063451
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NR5A2	IDA		Human	PMID:15143342
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Nr5a2	IDA		Mouse	MGI:MGI:6282985|PMID:30555544
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NR5A2	IDA		Human	PMID:15205472
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a2	IGI	UniProtKB:P33242	Mouse	MGI:MGI:5644022|PMID:19389484
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a2	IMP		Mouse	MGI:MGI:4889168|PMID:20937355
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a2	IDA		Mouse	MGI:MGI:2662795|PMID:12456679
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a2	IMP	MGI:MGI:3528835	Mouse	PMID:15831456
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nr5a2	IDA		Mouse	PMID:22977234
Biological Process	GO:0045070	positive regulation of viral genome replication	NR5A2	IDA		Human	PMID:19264593
Biological Process	GO:0042127	regulation of cell population proliferation	Nr5a2	IGI	MGI:MGI:88039	Mouse	PMID:15684064
Biological Process	GO:0006355	regulation of DNA-templated transcription	NR5A2	IDA		Human	PMID:15723037
Biological Process	GO:0006355	regulation of DNA-templated transcription	nr5a2	IGI	ZFIN:ZDB-GENE-030131-9689,ZFIN:ZDB-GENE-980526-362,ZFIN:ZDB-GENE-990415-79	Zfish	PMID:28642062
Biological Process	GO:0006355	regulation of DNA-templated transcription	nr5a2	IGI	ZFIN:ZDB-GENE-040426-2575,ZFIN:ZDB-GENE-980526-176,ZFIN:ZDB-GENE-990415-79	Zfish	PMID:28642062
Biological Process	GO:0006355	regulation of DNA-templated transcription	nr5a2	IGI	ZFIN:ZDB-GENE-980526-176,ZFIN:ZDB-GENE-980526-362,ZFIN:ZDB-GENE-990415-79	Zfish	PMID:28642062

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern