Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRF1
  • Mouse genes Nrf1
  • Rat genes Nrf1
  • Zfish genes nrf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NRF1	IDA		Human	PMID:19674972
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NRF1	IMP		Human	PMID:19674972
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	NRF1	IDA		Human	PMID:23525105
Molecular Function	GO:0005515	protein binding	NRF1	IPI	UniProtKB:P24385	Human	PMID:16864783
Molecular Function	GO:0005515	protein binding	NRF1	IPI	UniProtKB:Q02446	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NRF1	IPI	UniProtKB:Q12933	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NRF1	IPI	UniProtKB:Q14192	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NRF1	IPI	UniProtKB:Q7Z3K3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NRF1	IPI	UniProtKB:Q9NRC8	Human	PMID:25792330
Molecular Function	GO:0005515	protein binding	Nrf1	IPI	UniProtKB:P56558	Mouse	MGI:MGI:5700276|PMID:26231763
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NRF1	IDA		Human	PMID:19674972
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NRF1	IDA		Human	PMID:23525105
Cellular Component	GO:0005737	cytoplasm	Nrf1	IDA		Rat	PMID:16753268|RGD:2302407
Cellular Component	GO:0005829	cytosol	NRF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	NRF1	HDA		Human	PMID:19056867
Cellular Component	GO:0005654	nucleoplasm	NRF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nrf1	IDA		Rat	PMID:18062988|RGD:2302402
Biological Process	GO:0031100	animal organ regeneration	Nrf1	IEP		Rat	PMID:9501001|RGD:2298959
Biological Process	GO:0070417	cellular response to cold	nrf1	IDA		Zfish	PMID:16990399
Biological Process	GO:0007005	mitochondrion organization	Nrf1	IMP		Mouse	PMID:11134350
Biological Process	GO:0003407	neural retina development	nrf1	IMP		Zfish	PMID:9778497|ZFIN:ZDB-PUB-990105-7
Biological Process	GO:0003407	neural retina development	nrf1	IMP	ZFIN:ZDB-GENO-001221-3	Zfish	PMID:9778497
Biological Process	GO:0045494	photoreceptor cell maintenance	nrf1	IMP	ZFIN:ZDB-GENO-001221-3	Zfish	PMID:9778497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NRF1	IMP		Human	PMID:19674972
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NRF1	IMP		Human	PMID:23525105
Biological Process	GO:0014823	response to activity	nrf1	IDA		Zfish	PMID:16990399
Biological Process	GO:0051602	response to electrical stimulus	Nrf1	IDA		Rat	PMID:9575220|RGD:2302406
Biological Process	GO:0032355	response to estradiol	Nrf1	IEP		Rat	PMID:15994367|RGD:2302405
Biological Process	GO:0051593	response to folic acid	Nrf1	IEP		Rat	PMID:17709439|RGD:2302403
Biological Process	GO:0001666	response to hypoxia	Nrf1	IEP		Rat	PMID:18078825|RGD:2302401
Biological Process	GO:0032496	response to lipopolysaccharide	Nrf1	IEP		Rat	PMID:18062988|RGD:2302402
Biological Process	GO:0060041	retina development in camera-type eye	nrf1	IMP	ZFIN:ZDB-GENO-001221-3	Zfish	PMID:15716491
Biological Process	GO:0001895	retina homeostasis	nrf1	IMP	ZFIN:ZDB-GENO-001221-3	Zfish	PMID:9778497

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern