Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRG1
  • Mouse genes Nrg1
  • Rat genes Nrg1
  • Zfish genes nrg1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045499	chemorepellent activity	Nrg1	IDA		Mouse	PMID:22376909
Molecular Function	GO:0005176	ErbB-2 class receptor binding	Nrg1	IGI	MGI:MGI:104771	Mouse	PMID:9247262
Molecular Function	GO:0005176	ErbB-2 class receptor binding	Nrg1	IDA		Mouse	PMID:11425901
Molecular Function	GO:0043125	ErbB-3 class receptor binding	NRG1	IDA		Human	PMID:20682778
Molecular Function	GO:0005178	integrin binding	NRG1	IDA		Human	PMID:20682778
Molecular Function	GO:0005515	protein binding	Nrg1	IPI	UniProtKB:P56818,UniProtKB:Q8BHG1	Mouse	MGI:MGI:4414693|PMID:19935654
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	NRG1	IDA		Human	PMID:19632177
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	NRG1	IDA		Human	PMID:8702723
Molecular Function	GO:0048018	receptor ligand activity	NRG1	IDA		Human	PMID:19632177
Molecular Function	GO:0048018	receptor ligand activity	NRG1	IDA		Human	PMID:28822966
Molecular Function	GO:0048018	receptor ligand activity	NRG1	IDA		Human	PMID:8702723
Molecular Function	GO:0048018	receptor ligand activity	Nrg1	IDA		Mouse	PMID:16446434
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Nrg1	IDA		Rat	PMID:22659029|RGD:11035334
Molecular Function	GO:0003712	transcription coregulator activity	NRG1	IDA		Human	PMID:15073182
Cellular Component	GO:0030424	axon	Nrg1	IDA		Mouse	PMID:20220021
Cellular Component	GO:0005737	cytoplasm	Nrg1	IDA		Mouse	PMID:9789034
Cellular Component	GO:0005615	extracellular space	NRG1	IDA		Human	PMID:19632177
Cellular Component	GO:0005615	extracellular space	NRG1	IDA		Human	PMID:28822966
Cellular Component	GO:0005615	extracellular space	NRG1	IDA		Human	PMID:8702723
Cellular Component	GO:0005615	extracellular space	Nrg1	IDA		Rat	PMID:9417836|RGD:10449005
Cellular Component	GO:0098982	GABA-ergic synapse	Nrg1	IDA		Mouse	PMID:20393464
Cellular Component	GO:0098982	GABA-ergic synapse	Nrg1	IMP		Mouse	PMID:20393464
Cellular Component	GO:0098978	glutamatergic synapse	Nrg1	IDA		Mouse	PMID:15494726
Cellular Component	GO:0098978	glutamatergic synapse	Nrg1	IMP		Mouse	PMID:15494726
Cellular Component	GO:0097471	mossy fiber rosette	Nrg1	IDA		Mouse	PMID:10686589
Cellular Component	GO:0097471	mossy fiber rosette	Nrg1	EXP		Mouse	PMID:10686589
Cellular Component	GO:0097471	mossy fiber rosette	Nrg1	IPI		Mouse	PMID:10686589
Cellular Component	GO:0097471	mossy fiber rosette	Nrg1	IMP		Mouse	PMID:10686589
Cellular Component	GO:0031594	neuromuscular junction	Nrg1	IDA		Mouse	PMID:7589796
Cellular Component	GO:0005654	nucleoplasm	NRG1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Nrg1	IDA		Mouse	PMID:9789034
Cellular Component	GO:0005886	plasma membrane	Nrg1	IDA		Mouse	PMID:11425901
Cellular Component	GO:0098794	postsynapse	Nrg1	IDA		Mouse	PMID:24803543
Cellular Component	GO:0098839	postsynaptic density membrane	Nrg1	IDA		Mouse	PMID:10686589
Cellular Component	GO:0048787	presynaptic active zone membrane	Nrg1	IDA		Mouse	PMID:10686589
Cellular Component	GO:0045202	synapse	Nrg1	IDA		Mouse	PMID:7816098
Cellular Component	GO:0045202	synapse	Nrg1	IDA		Rat	PMID:20878784|RGD:10449029
Biological Process	GO:0032148	activation of protein kinase B activity	NRG1	IMP		Human	PMID:20682778
Biological Process	GO:0003161	cardiac conduction system development	Nrg1	IDA		Mouse	PMID:12149465
Biological Process	GO:0055007	cardiac muscle cell differentiation	Nrg1	IMP		Mouse	MGI:MGI:3701380|PMID:17336907
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	NRG1	IDA		Human	PMID:17336907
Biological Process	GO:0048738	cardiac muscle tissue development	Nrg1	IDA		Mouse	PMID:24364879
Biological Process	GO:0060959	cardiac neuron development	nrg1	IMP	ZFIN:ZDB-GENO-180709-2	Zfish	PMID:29265764
Biological Process	GO:0000902	cell morphogenesis	Nrg1	IDA		Mouse	PMID:9247262
Biological Process	GO:0021842	chemorepulsion involved in interneuron migration from the subpallium to the cortex	Nrg1	IMP		Mouse	PMID:22376909
Biological Process	GO:0060956	endocardial cell differentiation	NRG1	IDA		Human	PMID:17336907
Biological Process	GO:0048484	enteric nervous system development	nrg1	IMP	ZFIN:ZDB-MRPHLNO-170808-3	Zfish	PMID:28190554
Biological Process	GO:0038127	ERBB signaling pathway	NRG1	IDA		Human	PMID:11389077
Biological Process	GO:0038127	ERBB signaling pathway	NRG1	IMP		Human	PMID:20682778
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	NRG1	IDA		Human	PMID:8702723
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	NRG1	IDA		Human	PMID:19632177
Biological Process	GO:0038129	ERBB3 signaling pathway	NRG1	IDA		Human	PMID:27353365
Biological Process	GO:0038130	ERBB4 signaling pathway	NRG1	IDA		Human	PMID:28822966
Biological Process	GO:0038130	ERBB4 signaling pathway	Nrg1	IDA		Mouse	PMID:16446434
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	NRG1	IDA		Human	PMID:28822966
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	NRG1	IDA		Human	PMID:8702723
Biological Process	GO:0021755	eurydendroid cell differentiation	nrg1	IMP	ZFIN:ZDB-MRPHLNO-081222-2	Zfish	PMID:18996920
Biological Process	GO:0031101	fin regeneration	nrg1	IMP	ZFIN:ZDB-MRPHLNO-081222-2	Zfish	PMID:19133254
Biological Process	GO:0048699	generation of neurons	nrg1	IMP	ZFIN:ZDB-MRPHLNO-151007-3	Zfish	PMID:26001123
Biological Process	GO:0048699	generation of neurons	nrg1	IMP	ZFIN:ZDB-MRPHLNO-151007-4	Zfish	PMID:26001123
Biological Process	GO:0010001	glial cell differentiation	Nrg1	IMP	MGI:MGI:1928489	Mouse	PMID:12649319
Biological Process	GO:0021781	glial cell fate commitment	Nrg1	IDA		Mouse	PMID:21068328
Biological Process	GO:0007507	heart development	Nrg1	IMP	MGI:MGI:1928490	Mouse	PMID:7477375
Biological Process	GO:0007507	heart development	Nrg1	IMP	MGI:MGI:1928825	Mouse	PMID:9362461
Biological Process	GO:0007507	heart development	Nrg1	IMP	MGI:MGI:1928491	Mouse	PMID:8643489
Biological Process	GO:0007626	locomotory behavior	Nrg1	IMP	MGI:MGI:1928825	Mouse	PMID:10762692
Biological Process	GO:0000165	MAPK cascade	Nrg1	IDA		Mouse	PMID:8707830
Biological Process	GO:0007613	memory	Nrg1	IMP		Rat	PMID:23098760|RGD:10449010
Biological Process	GO:0007517	muscle organ development	Nrg1	IMP	MGI:MGI:1928831	Mouse	PMID:12495620
Biological Process	GO:0022011	myelination in peripheral nervous system	Nrg1	IMP		Mouse	PMID:25453108
Biological Process	GO:2000853	negative regulation of corticosterone secretion	Nrg1	IMP		Rat	PMID:21092742|RGD:10449008
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NRG1	IDA		Human	PMID:15073182
Biological Process	GO:2001223	negative regulation of neuron migration	Nrg1	IDA		Mouse	PMID:22376909
Biological Process	GO:0042177	negative regulation of protein catabolic process	Nrg1	IDA		Mouse	PMID:20448149
Biological Process	GO:0051048	negative regulation of secretion	NRG1	IDA		Human	PMID:10559227
Biological Process	GO:0007399	nervous system development	Nrg1	IMP	MGI:MGI:1928491	Mouse	PMID:8643489
Biological Process	GO:0001755	neural crest cell migration	nrg1	IGI	ZFIN:ZDB-MRPHLNO-081219-2,ZFIN:ZDB-MRPHLNO-081222-3	Zfish	PMID:18599505
Biological Process	GO:0048663	neuron fate commitment	Nrg1	IMP		Mouse	PMID:11425901
Biological Process	GO:0001764	neuron migration	Nrg1	IGI	MGI:MGI:104771	Mouse	PMID:9247262
Biological Process	GO:0045213	neurotransmitter receptor metabolic process	Nrg1	IMP	MGI:MGI:1928489	Mouse	PMID:9110980
Biological Process	GO:0042476	odontogenesis	Nrg1	IEP		Rat	PMID:12112465|RGD:727391
Biological Process	GO:0021778	oligodendrocyte cell fate specification	nrg1	IMP	ZFIN:ZDB-MRPHLNO-081222-2	Zfish	PMID:18996920
Biological Process	GO:0048709	oligodendrocyte differentiation	Nrg1	IMP	MGI:MGI:1928489	Mouse	PMID:11756753
Biological Process	GO:0007422	peripheral nervous system development	Nrg1	IMP	MGI:MGI:1928490	Mouse	PMID:7477375
Biological Process	GO:0007422	peripheral nervous system development	Nrg1	IMP	MGI:MGI:1928825	Mouse	PMID:9362461
Biological Process	GO:0007422	peripheral nervous system development	nrg1	IMP	ZFIN:ZDB-MRPHLNO-081222-3	Zfish	PMID:18599505
Biological Process	GO:0048680	positive regulation of axon regeneration	Nrg1	IDA		Rat	PMID:20957456|RGD:10449012
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	Nrg1	IGI	MGI:MGI:95411	Mouse	PMID:19179536
Biological Process	GO:2000727	positive regulation of cardiac muscle cell differentiation	Nrg1	IMP		Mouse	MGI:MGI:3701380|PMID:17336907
Biological Process	GO:0008284	positive regulation of cell population proliferation	NRG1	IMP		Human	PMID:20682778
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nrg1	IDA		Rat	PMID:19786050|RGD:10449023
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	NRG1	IMP		Human	PMID:20682778
Biological Process	GO:0010628	positive regulation of gene expression	Nrg1	IDA		Mouse	PMID:24364879
Biological Process	GO:0010976	positive regulation of neuron projection development	Nrg1	IDA		Rat	PMID:15555917|RGD:10449032
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Nrg1	IDA		Mouse	PMID:8702723
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Nrg1	IDA		Mouse	PMID:21186272
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Nrg1	IDA		Rat	PMID:20957456|RGD:10449012
Biological Process	GO:0045860	positive regulation of protein kinase activity	Nrg1	IDA		Mouse	PMID:7816098
Biological Process	GO:0045860	positive regulation of protein kinase activity	Nrg1	IDA		Mouse	PMID:10597237
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	Nrg1	IDA		Mouse	PMID:20448149
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	NRG1	IDA		Human	PMID:10559227
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	Nrg1	IDA		Mouse	PMID:8707830
Biological Process	GO:0010625	positive regulation of Schwann cell proliferation	Nrg1	IMP		Rat	PMID:9417836|RGD:10449005
Biological Process	GO:0051155	positive regulation of striated muscle cell differentiation	Nrg1	IMP		Mouse	MGI:MGI:3701380|PMID:17336907
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	Nrg1	IDA		Mouse	PMID:15494726
Biological Process	GO:0099527	postsynapse to nucleus signaling pathway	Nrg1	IMP		Mouse	PMID:15494726
Biological Process	GO:0030163	protein catabolic process	Nrg1	IDA		Mouse	PMID:20448149
Biological Process	GO:0043491	protein kinase B signaling	Nrg1	IDA		Mouse	PMID:20448149
Biological Process	GO:0045595	regulation of cell differentiation	Nrg1	IMP	MGI:MGI:1928489	Mouse	PMID:9892702
Biological Process	GO:0045595	regulation of cell differentiation	Nrg1	IMP		Mouse	PMID:11425901
Biological Process	GO:1905606	regulation of presynapse assembly	Nrg1	IMP		Mouse	PMID:20393464
Biological Process	GO:1905606	regulation of presynapse assembly	Nrg1	IDA		Mouse	PMID:20393464
Biological Process	GO:0032570	response to progesterone	Nrg1	IEP		Rat	PMID:17459743|RGD:2289991
Biological Process	GO:0014044	Schwann cell development	nrg1	IMP	ZFIN:ZDB-GENO-120309-6	Zfish	PMID:24642408
Biological Process	GO:0014037	Schwann cell differentiation	Nrg1	IMP	MGI:MGI:2447758,MGI:MGI:2447761	Mouse	PMID:16606832
Biological Process	GO:0036135	Schwann cell migration	nrg1	IMP	ZFIN:ZDB-GENO-120309-6	Zfish	PMID:21965611
Biological Process	GO:0007416	synapse assembly	Nrg1	IMP	MGI:MGI:1928831	Mouse	PMID:10707974
Biological Process	GO:0099560	synaptic membrane adhesion	Nrg1	IMP		Mouse	PMID:10686589
Biological Process	GO:0099560	synaptic membrane adhesion	Nrg1	IDA		Mouse	PMID:10686589
Biological Process	GO:0099560	synaptic membrane adhesion	Nrg1	EXP		Mouse	PMID:10686589
Biological Process	GO:0099560	synaptic membrane adhesion	Nrg1	IPI		Mouse	PMID:10686589
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	NRG1	IDA		Human	PMID:17336907
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	nrg1	IMP	ZFIN:ZDB-GENO-180709-6	Zfish	PMID:29265764

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern