Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRG2
  • Mouse genes Nrg2
  • Rat genes Nrg2
  • Zfish genes nrg2a,nrg2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005006	epidermal growth factor receptor activity	Nrg2	IDA		Rat	PMID:9348101|RGD:1304015
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Nrg2	IDA		Rat	PMID:9348101|RGD:1304015
Molecular Function	GO:0043125	ErbB-3 class receptor binding	Nrg2	IDA		Rat	PMID:9348101|RGD:1304015
Molecular Function	GO:1990631	ErbB-4 class receptor binding	Nrg2	IDA		Rat	PMID:24218551|RGD:126790483
Molecular Function	GO:0048018	receptor ligand activity	Nrg2	IDA		Mouse	PMID:16446434
Molecular Function	GO:0048018	receptor ligand activity	Nrg2	IPI	UniProtKB:Q15303	Mouse	PMID:9168115
Molecular Function	GO:0048018	receptor ligand activity	Nrg2	IDA		Mouse	PMID:9168115
Molecular Function	GO:0048018	receptor ligand activity	Nrg2	IDA		Mouse	PMID:9742126
Molecular Function	GO:0048018	receptor ligand activity	Nrg2	IDA		Rat	PMID:12466964|RGD:151356654
Cellular Component	GO:0005615	extracellular space	Nrg2	IDA		Mouse	PMID:9168115
Cellular Component	GO:0005615	extracellular space	Nrg2	IPI	UniProtKB:Q15303	Mouse	PMID:9168115
Cellular Component	GO:0005615	extracellular space	Nrg2	IDA		Mouse	PMID:16446434
Cellular Component	GO:0005615	extracellular space	Nrg2	IDA		Mouse	PMID:9742126
Cellular Component	GO:0005615	extracellular space	Nrg2	IDA		Rat	PMID:12466964|RGD:151356654
Cellular Component	GO:0098982	GABA-ergic synapse	Nrg2	IDA		Rat	PMID:26674872|RGD:11070025
Cellular Component	GO:0098982	GABA-ergic synapse	Nrg2	IMP		Rat	PMID:26674872|RGD:11070025
Cellular Component	GO:0098978	glutamatergic synapse	Nrg2	IDA		Rat	PMID:26674872|RGD:11070025
Cellular Component	GO:0098978	glutamatergic synapse	Nrg2	IMP		Rat	PMID:26674872|RGD:11070025
Biological Process	GO:0007166	cell surface receptor signaling pathway	Nrg2	IDA		Mouse	PMID:9168115
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Nrg2	IDA		Rat	PMID:9348101|RGD:1304015
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	Nrg2	IDA		Mouse	PMID:9742126
Biological Process	GO:0038130	ERBB4 signaling pathway	Nrg2	IPI	UniProtKB:Q15303	Mouse	PMID:9168115
Biological Process	GO:0038130	ERBB4 signaling pathway	Nrg2	IDA		Mouse	PMID:16446434
Biological Process	GO:0038130	ERBB4 signaling pathway	Nrg2	IDA		Rat	PMID:12466964|RGD:151356654
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Nrg2	IDA		Mouse	PMID:9168115
Biological Process	GO:0060347	heart trabecula formation	nrg2a	IMP	ZFIN:ZDB-GENO-151015-18	Zfish	PMID:28485381
Biological Process	GO:0001755	neural crest cell migration	nrg2a	IGI	ZFIN:ZDB-MRPHLNO-081219-2,ZFIN:ZDB-MRPHLNO-081222-3	Zfish	PMID:18599505
Biological Process	GO:0007422	peripheral nervous system development	nrg2a	IMP	ZFIN:ZDB-MRPHLNO-081219-2	Zfish	PMID:18599505
Biological Process	GO:0051963	regulation of synapse assembly	Nrg2	IDA		Rat	PMID:26674872|RGD:11070025
Biological Process	GO:0051963	regulation of synapse assembly	Nrg2	IMP		Rat	PMID:26674872|RGD:11070025
Biological Process	GO:0090128	regulation of synapse maturation	Nrg2	IDA		Rat	PMID:26674872|RGD:11070025
Biological Process	GO:0090128	regulation of synapse maturation	Nrg2	IMP		Rat	PMID:26674872|RGD:11070025
Biological Process	GO:0098773	skin epidermis development	nrg2a	IMP	ZFIN:ZDB-GENO-151015-18	Zfish	PMID:26110643
Biological Process	GO:0098773	skin epidermis development	nrg2a	IGI	ZFIN:ZDB-GENO-151015-18,ZFIN:ZDB-MRPHLNO-050817-1	Zfish	PMID:26110643
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	nrg2a	IMP	ZFIN:ZDB-GENO-170523-2	Zfish	PMID:27926871

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern