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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nrxn1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrxn1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0033130acetylcholine receptor bindingNrxn1IDAMousePMID:19567877
Molecular FunctionGO:0005246calcium channel regulator activityNrxn1IGIMGI:MGI:1096389MousePMID:12827191
Molecular FunctionGO:0005246calcium channel regulator activityNrxn1IGIMGI:MGI:1096362MousePMID:12827191
Molecular FunctionGO:0005509calcium ion bindingNrxn1IDARatPMID:18334216|RGD:2314455
Molecular FunctionGO:0048306calcium-dependent protein bindingNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:Q69ZK9MouseMGI:MGI:5285129|PMID:21424692
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:Q99K10MouseMGI:MGI:5284755|PMID:19098102
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:Q99K10MouseMGI:MGI:2665153|PMID:12796785
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:D4A7P2MouseMGI:MGI:5285129|PMID:21424692
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:Q62889RatPMID:15152050|RGD:8553271
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:Q62765RatPMID:15797875|RGD:8554205
Molecular FunctionGO:0050839cell adhesion molecule bindingNrxn1IPIUniProtKB:Q62765RatPMID:19730411|RGD:8554379
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q69ZK9MouseMGI:MGI:5285129|PMID:21424692
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q99K10MouseMGI:MGI:2665153|PMID:12796785
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q99K10MouseMGI:MGI:5284755|PMID:19098102
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q62765RatPMID:14522992|RGD:13210536
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q62889RatPMID:15152050|RGD:8553271
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q62765RatPMID:15797875|RGD:8554205
Molecular FunctionGO:0097109neuroligin family protein bindingNrxn1IPIUniProtKB:Q62765RatPMID:19730411|RGD:8554379
Molecular FunctionGO:0005515protein bindingNRXN1IPIUniProtKB:Q9H190HumanPMID:11152476
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:Q8BGU2|UniProtKB:Q8BME9|UniProtKB:Q9R171MouseMGI:MGI:6271505|PMID:29782851
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:Q9R171MouseMGI:MGI:4839424|PMID:20537373
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:O14522MouseMGI:MGI:5508578|PMID:19816407
Molecular FunctionGO:0005515protein bindingNrxn1IPIPR:Q8BME9MousePMID:21356198
Molecular FunctionGO:0005515protein bindingNrxn1IPIPR:Q69ZK9MousePMID:29107521
Molecular FunctionGO:0005515protein bindingNrxn1IPIPR:Q99JH7MousePMID:24094106
Molecular FunctionGO:0005515protein bindingNrxn1IPIPR:Q9R171MousePMID:21356198
Molecular FunctionGO:0005515protein bindingNrxn1IPIPR:Q8BGU2MousePMID:21356198
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:Q8N0W4RatPMID:18093521|RGD:8553862
Molecular FunctionGO:0005515protein bindingNrxn1IPIRGD:621117RatPMID:18093522|RGD:2314457
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:O14936RatPMID:18423203|RGD:8553987
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:Q62765-2RatPMID:20543817|RGD:8553972
Molecular FunctionGO:0005515protein bindingNrxn1IPIUniProtKB:Q8N0W4RatPMID:20543817|RGD:8553972
Molecular FunctionGO:0044877protein-containing complex bindingNrxn1IDARatPMID:18093522|RGD:2314457
Molecular FunctionGO:0005102signaling receptor bindingNrxn1IPIUniProtKB:Q62765RatPMID:15797875|RGD:8554205
Molecular FunctionGO:0004888transmembrane signaling receptor activityNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Molecular FunctionGO:0004888transmembrane signaling receptor activityNrxn1IDARatPMID:15797875|RGD:8554205
Cellular ComponentGO:0044295axonal growth coneNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Cellular ComponentGO:0009986cell surfaceNRXN1IDAHumanPMID:21424692
Cellular ComponentGO:0009986cell surfaceNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Cellular ComponentGO:0009986cell surfaceNrxn1IDAMouseMGI:MGI:5285129|PMID:21424692
Cellular ComponentGO:0009986cell surfaceNrxn1IDARatPMID:15797875|RGD:8554205
Cellular ComponentGO:0030139endocytic vesicleNrxn1IDARatPMID:15797875|RGD:8554205
Cellular ComponentGO:0005783endoplasmic reticulumNrxn1IDAMouseMGI:MGI:3821631|PMID:19036990
Cellular ComponentGO:0098982GABA-ergic synapseNrxn1IMPMousePMID:15620359
Cellular ComponentGO:0098982GABA-ergic synapseNrxn1IDAMousePMID:15620359
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IDAMousePMID:21410790
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IPIMousePMID:21410790
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IMPMousePMID:21410790
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IDAMousePMID:17360903
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IMPMousePMID:17360903
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IDAMousePMID:15620359
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IMPMousePMID:15620359
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IPIMousePMID:31995730
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IMPMousePMID:31995730
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IDAMousePMID:31995730
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IDAMousePMID:19036990
Cellular ComponentGO:0098978glutamatergic synapseNrxn1IMPMousePMID:19036990
Cellular ComponentGO:0043025neuronal cell bodyNrxn1IDAMouseMGI:MGI:3821631|PMID:19036990
Cellular ComponentGO:0031965nuclear membraneNrxn1IDAMouseMGI:MGI:3821631|PMID:19036990
Cellular ComponentGO:0005730nucleolusNRXN1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005886plasma membraneNRXN1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005886plasma membraneNrxn1IDARatPMID:18755801|RGD:2314456
Cellular ComponentGO:0005886plasma membraneNrxn1IDARatPMID:22235116|RGD:8553305
Cellular ComponentGO:0048787presynaptic active zone membraneNrxn1IDAMousePMID:17360903
Cellular ComponentGO:0048787presynaptic active zone membraneNrxn1IMPMousePMID:17360903
Cellular ComponentGO:0042734presynaptic membraneNrxn1IDAMousePMID:12827191
Cellular ComponentGO:0042734presynaptic membraneNrxn1IDAMousePMID:19036990
Cellular ComponentGO:0042734presynaptic membraneNrxn1IMPMousePMID:19036990
Cellular ComponentGO:0042734presynaptic membraneNrxn1IDAMousePMID:27872870
Cellular ComponentGO:0042734presynaptic membraneNrxn1IMPMousePMID:27872870
Cellular ComponentGO:0098635protein complex involved in cell-cell adhesionNrxn1EXPMouseMGI:MGI:5916338|PMID:18084303
Cellular ComponentGO:0032991protein-containing complexNrxn1IPIPR:Q99JH7MousePMID:24613359
Cellular ComponentGO:0032991protein-containing complexNrxn1IPIUniProtKB:Q8N2Q7MousePMID:24613359
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseNrxn1IMPMousePMID:19036990
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseNrxn1IDAMousePMID:19036990
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseNrxn1IDAMousePMID:19822762
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseNrxn1IMPMousePMID:19822762
Cellular ComponentGO:0036057slit diaphragmNrxn1IDARatPMID:21048075|RGD:13207335
Cellular ComponentGO:0031982vesicleNrxn1IDAMouseMGI:MGI:3821631|PMID:19036990
Biological ProcessGO:0030534adult behaviorNRXN1IMPHumanPMID:19896112
Biological ProcessGO:0030534adult behaviorNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0071277cellular response to calcium ionNrxn1IDARatPMID:14522992|RGD:13210536
Biological ProcessGO:0021707cerebellar granule cell differentiationNrxn1IGIUniProtKB:Q61625|UniProtKB:Q9R171MouseMGI:MGI:4839424|PMID:20537373
Biological ProcessGO:0007268chemical synaptic transmissionNrxn1IGIMGI:MGI:1096389MousePMID:12827191
Biological ProcessGO:0007268chemical synaptic transmissionNrxn1IGIMGI:MGI:1096362MousePMID:12827191
Biological ProcessGO:0007623circadian rhythmNrxn1IEPRatPMID:22662246|RGD:13207344
Biological ProcessGO:0045184establishment of protein localizationNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0046847filopodium assemblyNrxn1IMPMouseMGI:MGI:5306551|PMID:20869594
Biological ProcessGO:0097112gamma-aminobutyric acid receptor clusteringNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097116gephyrin clustering involved in postsynaptic density assemblyNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097116gephyrin clustering involved in postsynaptic density assemblyNrxn1IDAMouseMGI:MGI:5285129|PMID:21424692
Biological ProcessGO:0097117guanylate kinase-associated protein clusteringNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesNrxn1IGIUniProtKB:Q61625|UniProtKB:Q9R171MouseMGI:MGI:4839424|PMID:20537373
Biological ProcessGO:0007612learningNRXN1IMPHumanPMID:19896112
Biological ProcessGO:0007612learningNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:0051490negative regulation of filopodium assemblyNrxn1IDAMouseMGI:MGI:5306551|PMID:20869594
Biological ProcessGO:0097118neuroligin clustering involved in postsynaptic membrane assemblyNrxn1IDAMouseMGI:MGI:5285129|PMID:21424692
Biological ProcessGO:0097118neuroligin clustering involved in postsynaptic membrane assemblyNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0050885neuromuscular process controlling balanceNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:0007158neuron cell-cell adhesionNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0042551neuron maturationNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0007269neurotransmitter secretionNrxn1IGIMGI:MGI:1096362MousePMID:12827191
Biological ProcessGO:0007269neurotransmitter secretionNrxn1IGIMGI:MGI:1096389MousePMID:12827191
Biological ProcessGO:0097114NMDA glutamate receptor clusteringNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:2000463positive regulation of excitatory postsynaptic potentialNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Biological ProcessGO:1903078positive regulation of protein localization to plasma membraneNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Biological ProcessGO:0051965positive regulation of synapse assemblyNrxn1IGIMGI:MGI:88282MousePMID:21356198
Biological ProcessGO:0051965positive regulation of synapse assemblyNrxn1IGIMGI:MGI:88281MousePMID:21356198
Biological ProcessGO:0090129positive regulation of synapse maturationNrxn1IDAMousePMID:19567877
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:0051968positive regulation of synaptic transmission, glutamatergicNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNrxn1IDAMouseMGI:MGI:5285129|PMID:21424692
Biological ProcessGO:0097119postsynaptic density protein 95 clusteringNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097104postsynaptic membrane assemblyNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:0097104postsynaptic membrane assemblyNrxn1IDAMouseMGI:MGI:5285129|PMID:21424692
Biological ProcessGO:0060134prepulse inhibitionNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:0099054presynapse assemblyNrxn1IMPMousePMID:21410790
Biological ProcessGO:0099054presynapse assemblyNrxn1IDAMousePMID:21410790
Biological ProcessGO:0099054presynapse assemblyNrxn1IPIMousePMID:21410790
Biological ProcessGO:0099054presynapse assemblyNrxn1EXPRatPMID:12796785|RGD:13702298
Biological ProcessGO:0099054presynapse assemblyNrxn1IDARatPMID:12796785|RGD:13702298
Biological ProcessGO:0099054presynapse assemblyNrxn1IMPRatPMID:12796785|RGD:13702298
Biological ProcessGO:0097105presynaptic membrane assemblyNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0035418protein localization to synapseNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0090126protein-containing complex assembly involved in synapse maturationNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0097120receptor localization to synapseNrxn1IDAMouseMGI:MGI:5284797|PMID:15620359
Biological ProcessGO:2000311regulation of AMPA receptor activityNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Biological ProcessGO:2000311regulation of AMPA receptor activityNrxn1IDAMouseMGI:MGI:5306551|PMID:20869594
Biological ProcessGO:2000821regulation of grooming behaviorNrxn1IMPMouseMGI:MGI:4366191|PMID:19822762
Biological ProcessGO:2000310regulation of NMDA receptor activityNrxn1IDAMouseMGI:MGI:5284755|PMID:19098102
Biological ProcessGO:0099151regulation of postsynaptic density assemblyNrxn1IDAMousePMID:21410790
Biological ProcessGO:0099151regulation of postsynaptic density assemblyNrxn1IMPMousePMID:21410790
Biological ProcessGO:0099150regulation of postsynaptic specialization assemblyNrxn1IDAMousePMID:15620359
Biological ProcessGO:0099150regulation of postsynaptic specialization assemblyNrxn1IMPMousePMID:15620359
Biological ProcessGO:1905606regulation of presynapse assemblyNrxn1IMPMousePMID:17360903
Biological ProcessGO:1905606regulation of presynapse assemblyNrxn1IDAMousePMID:17360903
Biological ProcessGO:0098693regulation of synaptic vesicle cycleNrxn1IDAMousePMID:19822762
Biological ProcessGO:0098693regulation of synaptic vesicle cycleNrxn1IMPMousePMID:19822762
Biological ProcessGO:0150036regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmissionNrxn1IDAMousePMID:26213384
Biological ProcessGO:0150036regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmissionNrxn1IMPMousePMID:26213384
Biological ProcessGO:0007165signal transductionNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0007165signal transductionNrxn1IDARatPMID:15797875|RGD:8554205
Biological ProcessGO:0035176social behaviorNRXN1IMPHumanPMID:18057082
Biological ProcessGO:0035176social behaviorNRXN1IMPHumanPMID:19896112
Biological ProcessGO:0002040sprouting angiogenesisnrxn1aIGIZFIN:ZDB-MRPHLNO-120719-2,ZFIN:ZDB-MRPHLNO-120719-4ZfishPMID:22516065
Biological ProcessGO:0002040sprouting angiogenesisnrxn1aIGIZFIN:ZDB-MRPHLNO-080516-7,ZFIN:ZDB-MRPHLNO-120719-2ZfishPMID:22516065
Biological ProcessGO:0002040sprouting angiogenesisnrxn1aIMPZFIN:ZDB-MRPHLNO-120719-2ZfishPMID:22516065
Biological ProcessGO:0007416synapse assemblyNrxn1IGIMGI:MGI:1096362MousePMID:12827191
Biological ProcessGO:0007416synapse assemblyNrxn1IGIMGI:MGI:1096389MousePMID:12827191
Biological ProcessGO:0007416synapse assemblyNrxn1IGIMGI:MGI:88282MousePMID:21356198
Biological ProcessGO:0007416synapse assemblyNrxn1IGIMGI:MGI:88281MousePMID:21356198
Biological ProcessGO:0007416synapse assemblyNrxn1IMPMousePMID:31995730
Biological ProcessGO:0007416synapse assemblyNrxn1IPIMousePMID:31995730
Biological ProcessGO:0007416synapse assemblyNrxn1IDAMousePMID:31995730
Biological ProcessGO:0099560synaptic membrane adhesionNrxn1IMPMouseMGI:MGI:5763518|PMID:26771491
Biological ProcessGO:0099560synaptic membrane adhesionNrxn1IDAMousePMID:12796785
Biological ProcessGO:0099560synaptic membrane adhesionNrxn1IMPMousePMID:12796785
Biological ProcessGO:0097091synaptic vesicle clusteringNrxn1IDAMouseMGI:MGI:2665153|PMID:12796785
Biological ProcessGO:0006904vesicle docking involved in exocytosisNrxn1IMPRatPMID:22235116|RGD:8553305
Biological ProcessGO:0042297vocal learningNRXN1IMPHumanPMID:19896112
Biological ProcessGO:0071625vocalization behaviorNRXN1IMPHumanPMID:18057082
Biological ProcessGO:0071625vocalization behaviorNRXN1IMPHumanPMID:19896112

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory