Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRXN2
  • Mouse genes Nrxn2
  • Rat genes Nrxn2
  • Zfish genes nrxn2a,nrxn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrxn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005246	calcium channel regulator activity	Nrxn2	IGI	MGI:MGI:1096389	Mouse	PMID:12827191
Molecular Function	GO:0005246	calcium channel regulator activity	Nrxn2	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Molecular Function	GO:0050839	cell adhesion molecule binding	Nrxn2	IPI	UniProtKB:D4A7P2|UniProtKB:Q69ZK9	Mouse	MGI:MGI:5285129|PMID:21424692
Molecular Function	GO:0097109	neuroligin family protein binding	Nrxn2	IPI	UniProtKB:Q69ZK9	Mouse	MGI:MGI:5285129|PMID:21424692
Molecular Function	GO:0005515	protein binding	Nrxn2	IPI	UniProtKB:Q7TNR6	Mouse	MGI:MGI:5925767|PMID:28864826
Molecular Function	GO:0005515	protein binding	Nrxn2	IPI	PR:Q8BGU2	Mouse	PMID:21356198
Molecular Function	GO:0005515	protein binding	Nrxn2	IPI	PR:Q8BME9	Mouse	PMID:21356198
Molecular Function	GO:0005515	protein binding	Nrxn2	IPI	PR:Q9R171	Mouse	PMID:21356198
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Nrxn2	IDA		Mouse	MGI:MGI:5285129|PMID:21424692
Cellular Component	GO:0098978	glutamatergic synapse	Nrxn2	IDA		Mouse	PMID:25745399
Cellular Component	GO:0098978	glutamatergic synapse	Nrxn2	IMP		Mouse	PMID:25745399
Cellular Component	GO:0032991	protein-containing complex	Nrxn2	IPI	PR:Q99JH7	Mouse	PMID:24613359
Cellular Component	GO:0032991	protein-containing complex	Nrxn2	IPI	UniProtKB:Q8N2Q7	Mouse	PMID:24613359
Biological Process	GO:0030534	adult behavior	NRXN2	IMP		Human	PMID:21424692
Biological Process	GO:0048846	axon extension involved in axon guidance	nrxn2a	IMP	ZFIN:ZDB-GENO-220112-16	Zfish	PMID:33276371
Biological Process	GO:0007268	chemical synaptic transmission	Nrxn2	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Biological Process	GO:0007268	chemical synaptic transmission	Nrxn2	IGI	MGI:MGI:1096389	Mouse	PMID:12827191
Biological Process	GO:0007268	chemical synaptic transmission	nrxn2a	IMP	ZFIN:ZDB-MRPHLNO-140424-3	Zfish	PMID:24218366
Biological Process	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	Nrxn2	IDA		Mouse	MGI:MGI:5285129|PMID:21424692
Biological Process	GO:0008045	motor neuron axon guidance	nrxn2a	IMP	ZFIN:ZDB-MRPHLNO-140422-3,ZFIN:ZDB-MRPHLNO-140424-1	Zfish	PMID:24218366
Biological Process	GO:0008045	motor neuron axon guidance	nrxn2a	IMP	ZFIN:ZDB-MRPHLNO-140424-3	Zfish	PMID:24218366
Biological Process	GO:0008045	motor neuron axon guidance	nrxn2a	IMP	ZFIN:ZDB-MRPHLNO-140424-2,ZFIN:ZDB-MRPHLNO-140424-3	Zfish	PMID:24218366
Biological Process	GO:0008045	motor neuron axon guidance	nrxn2a	IMP	ZFIN:ZDB-MRPHLNO-140422-3,ZFIN:ZDB-MRPHLNO-140424-1,ZFIN:ZDB-MRPHLNO-140424-2,ZFIN:ZDB-MRPHLNO-140424-3	Zfish	PMID:24218366
Biological Process	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	Nrxn2	IDA		Mouse	MGI:MGI:5285129|PMID:21424692
Biological Process	GO:0007528	neuromuscular junction development	nrxn2a	IMP	ZFIN:ZDB-GENO-220112-16	Zfish	PMID:33276371
Biological Process	GO:0007269	neurotransmitter secretion	Nrxn2	IGI	MGI:MGI:1096389	Mouse	PMID:12827191
Biological Process	GO:0007269	neurotransmitter secretion	Nrxn2	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	Nrxn2	IDA		Mouse	MGI:MGI:5285129|PMID:21424692
Biological Process	GO:0097104	postsynaptic membrane assembly	Nrxn2	IDA		Mouse	MGI:MGI:5285129|PMID:21424692
Biological Process	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	Nrxn2	IDA		Mouse	PMID:25745399
Biological Process	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	Nrxn2	IMP		Mouse	PMID:25745399
Biological Process	GO:0007165	signal transduction	Nrxn2	IDA		Mouse	MGI:MGI:5285129|PMID:21424692
Biological Process	GO:0035176	social behavior	NRXN2	IMP		Human	PMID:21424692
Biological Process	GO:0007416	synapse assembly	Nrxn2	IGI	MGI:MGI:1096391	Mouse	PMID:12827191
Biological Process	GO:0007416	synapse assembly	Nrxn2	IGI	MGI:MGI:1096389	Mouse	PMID:12827191
Biological Process	GO:0042297	vocal learning	NRXN2	IMP		Human	PMID:21424692
Biological Process	GO:0071625	vocalization behavior	NRXN2	IMP		Human	PMID:21424692

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern