Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NSD1
  • Mouse genes Nsd1
  • Rat genes Nsd1
  • Zfish genes nsd1a,nsd1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nsd1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nsd1	IDA		Mouse	PMID:15522233
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	NSD1	IMP		Human	PMID:20837538
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	NSD1	IDA		Human	PMID:21196496
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	Nsd1	IDA		Mouse	MGI:MGI:2664413|PMID:12805229
Molecular Function	GO:0042799	histone H4K20 methyltransferase activity	Nsd1	IDA		Mouse	MGI:MGI:2664413|PMID:12805229
Molecular Function	GO:0042054	histone methyltransferase activity	Nsd1	IDA		Mouse	PMID:12805229
Molecular Function	GO:0050681	nuclear androgen receptor binding	NSD1	IDA		Human	PMID:11509567
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Nsd1	IPI	UniProtKB:P03372	Mouse	MGI:MGI:1267129|PMID:9628876
Molecular Function	GO:0042974	nuclear retinoic acid receptor binding	Nsd1	IPI	UniProtKB:P10276	Mouse	MGI:MGI:1267129|PMID:9628876
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	Nsd1	IPI	UniProtKB:P28700	Mouse	MGI:MGI:1267129|PMID:9628876
Molecular Function	GO:0046966	nuclear thyroid hormone receptor binding	Nsd1	IPI	UniProtKB:P04625	Mouse	MGI:MGI:1267129|PMID:9628876
Molecular Function	GO:0005515	protein binding	NSD1	IPI	UniProtKB:Q04206	Human	PMID:20080798
Molecular Function	GO:0005515	protein binding	Nsd1	IPI	PR:Q5SXI5	Mouse	PMID:15169884
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NSD1	IDA		Human	PMID:20837538
Molecular Function	GO:0003712	transcription coregulator activity	NSD1	IDA		Human	PMID:11509567
Molecular Function	GO:0003712	transcription coregulator activity	Nsd1	IDA		Mouse	PMID:9628876
Molecular Function	GO:0003714	transcription corepressor activity	Nsd1	IDA		Mouse	MGI:MGI:1267129|PMID:9628876
Molecular Function	GO:0008270	zinc ion binding	NSD1	IDA		Human	PMID:21196496
Cellular Component	GO:0005634	nucleus	Nsd1	IDA		Mouse	PMID:18157086
Biological Process	GO:0001702	gastrulation with mouth forming second	Nsd1	IMP	MGI:MGI:2667262	Mouse	PMID:12805229
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nsd1	IDA		Mouse	MGI:MGI:1267129|PMID:9628876
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NSD1	IDA		Human	PMID:11509567
Biological Process	GO:0033135	regulation of peptidyl-serine phosphorylation	NSD1	IMP		Human	PMID:20837538
Biological Process	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	NSD1	IMP		Human	PMID:20837538

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern