Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NSD2
  • Mouse genes Nsd2
  • Rat genes Nsd2
  • Zfish genes nsd2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nsd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Nsd2	IDA		Mouse	PMID:19483677
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	NSD2	IMP		Human	PMID:33941880
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	nsd2	IMP	ZFIN:ZDB-GENO-190325-3	Zfish	PMID:28654864
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	nsd2	IMP	ZFIN:ZDB-GENO-190325-2	Zfish	PMID:28654864
Molecular Function	GO:0046975	histone H3K36 methyltransferase activity	nsd2	IMP	ZFIN:ZDB-MRPHLNO-101129-1	Zfish	PMID:20946879
Molecular Function	GO:0140955	histone H3K36 trimethyltransferase activity	Nsd2	IDA		Mouse	PMID:19483677
Molecular Function	GO:0042054	histone methyltransferase activity	Nsd2	IDA		Mouse	PMID:23241889
Molecular Function	GO:0042054	histone methyltransferase activity	Nsd2	IDA		Mouse	PMID:19483677
Molecular Function	GO:0005515	protein binding	NSD2	IPI	UniProtKB:P10275	Human	PMID:19481544
Molecular Function	GO:0005515	protein binding	NSD2	IPI	UniProtKB:Q14676	Human	PMID:21293379
Molecular Function	GO:0005515	protein binding	NSD2	IPI	UniProtKB:Q8N7B1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	NSD2	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Nsd2	IPI	UniProtKB:P42582|UniProtKB:Q8BX22	Mouse	MGI:MGI:3850584|PMID:19483677
Molecular Function	GO:0043565	sequence-specific DNA binding	Nsd2	IDA		Mouse	PMID:23241889
Cellular Component	GO:0005654	nucleoplasm	NSD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Nsd2	IDA		Mouse	PMID:19483677
Biological Process	GO:0003289	atrial septum primum morphogenesis	Nsd2	IMP	MGI:MGI:3851507	Mouse	PMID:19483677
Biological Process	GO:0003290	atrial septum secundum morphogenesis	Nsd2	IMP	MGI:MGI:3851507	Mouse	PMID:19483677
Biological Process	GO:0060348	bone development	Nsd2	IMP	MGI:MGI:3851507	Mouse	PMID:19483677
Biological Process	GO:0051216	cartilage development	nsd2	IMP	ZFIN:ZDB-MRPHLNO-101129-1	Zfish	PMID:20946879
Biological Process	GO:0048706	embryonic skeletal system development	nsd2	IMP	ZFIN:ZDB-MRPHLNO-101129-1	Zfish	PMID:20946879
Biological Process	GO:0016570	histone modification	Nsd2	IDA		Mouse	MGI:MGI:3850584|PMID:19483677
Biological Process	GO:0016570	histone modification	nsd2	IMP	ZFIN:ZDB-MRPHLNO-101129-1	Zfish	PMID:20946879|ZFIN:ZDB-PUB-101018-30
Biological Process	GO:0003149	membranous septum morphogenesis	Nsd2	IMP	MGI:MGI:3851507	Mouse	PMID:19483677
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Nsd2	IGI	MGI:MGI:97350	Mouse	PMID:19483677
Biological Process	GO:0048298	positive regulation of isotype switching to IgA isotypes	Nsd2	IMP		Mouse	PMID:23241889
Biological Process	GO:0006479	protein methylation	nsd2	IMP	ZFIN:ZDB-MRPHLNO-101129-1	Zfish	PMID:20946879|ZFIN:ZDB-PUB-101018-30
Biological Process	GO:0006355	regulation of DNA-templated transcription	Nsd2	IMP		Mouse	PMID:23241889
Biological Process	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	Nsd2	IMP		Mouse	PMID:23241889
Biological Process	GO:0070201	regulation of establishment of protein localization	Nsd2	IMP		Mouse	PMID:23241889

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern