Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NTHL1
  • Mouse genes Nthl1
  • Rat genes Nthl1
  • Zfish genes nthl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nthl1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	NTHL1	IDA		Human	PMID:8990169
Molecular Function	GO:0003684	damaged DNA binding	NTHL1	IDA		Human	PMID:9927729
Molecular Function	GO:0019104	DNA N-glycosylase activity	NTHL1	IDA		Human	PMID:10882850
Molecular Function	GO:0019104	DNA N-glycosylase activity	Nthl1	IDA		Mouse	MGI:MGI:1289919|PMID:9743625
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	NTHL1	IDA		Human	PMID:8990169
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	NTHL1	IDA		Human	PMID:9927729
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	Nthl1	IDA		Mouse	MGI:MGI:1289919|PMID:9743625
Molecular Function	GO:0003690	double-stranded DNA binding	NTHL1	IDA		Human	PMID:15358233
Molecular Function	GO:0005515	protein binding	NTHL1	IPI	UniProtKB:P12004	Human	PMID:15358233
Molecular Function	GO:0005515	protein binding	NTHL1	IPI	UniProtKB:P28715	Human	PMID:15358233
Molecular Function	GO:0005515	protein binding	NTHL1	IPI	UniProtKB:P28715	Human	PMID:9927729
Cellular Component	GO:0005739	mitochondrion	Nthl1	IDA		Mouse	PMID:12531031
Cellular Component	GO:0005739	mitochondrion	Nthl1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Nthl1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005634	nucleus	NTHL1	IDA		Human	PMID:12531031
Cellular Component	GO:0005634	nucleus	Nthl1	IDA		Mouse	PMID:12531031
Biological Process	GO:0006285	base-excision repair, AP site formation	NTHL1	IDA		Human	PMID:15358233
Biological Process	GO:0006285	base-excision repair, AP site formation	NTHL1	IDA		Human	PMID:9927729
Biological Process	GO:0006289	nucleotide-excision repair	NTHL1	IDA		Human	PMID:8990169
Biological Process	GO:0006289	nucleotide-excision repair	Nthl1	IDA		Mouse	MGI:MGI:1289919|PMID:9743625

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern