Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NTRK1
  • Mouse genes Ntrk1
  • Rat genes Ntrk1
  • Zfish genes ntrk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ntrk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	Ntrk1	IDA		Rat	PMID:19036963|RGD:8553786
Molecular Function	GO:0042802	identical protein binding	NTRK1	IPI	UniProtKB:P04629	Human	PMID:21187090
Molecular Function	GO:0042802	identical protein binding	NTRK1	IPI	UniProtKB:P04629	Human	PMID:28197073
Molecular Function	GO:0019900	kinase binding	Ntrk1	IPI	RGD:1332211	Rat	PMID:10679771|RGD:8693411
Molecular Function	GO:0019900	kinase binding	Ntrk1	IPI	RGD:1584969	Rat	PMID:10679771|RGD:8693411
Molecular Function	GO:0048406	nerve growth factor binding	NTRK1	IDA		Human	PMID:1281417
Molecular Function	GO:0048406	nerve growth factor binding	NTRK1	IDA		Human	PMID:15488758
Molecular Function	GO:0048406	nerve growth factor binding	NTRK1	IDA		Human	PMID:17196528
Molecular Function	GO:0048406	nerve growth factor binding	Ntrk1	IDA		Rat	PMID:9753156|RGD:5508802
Molecular Function	GO:0010465	nerve growth factor receptor activity	NTRK1	IMP		Human	PMID:1281417
Molecular Function	GO:0010465	nerve growth factor receptor activity	NTRK1	IDA		Human	PMID:15488758
Molecular Function	GO:0005166	neurotrophin p75 receptor binding	Ntrk1	IPI	RGD:3177	Rat	PMID:9753156|RGD:5508802
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P01138	Human	PMID:10490030
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P18031	Human	PMID:12237455
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P01138	Human	PMID:14985763
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P01138:PRO_0000019600	Human	PMID:14985763
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P19174	Human	PMID:15488758
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P27986	Human	PMID:15488758
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P29353	Human	PMID:15488758
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P62993	Human	PMID:15488758
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q8WU20	Human	PMID:15488758
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:O75385	Human	PMID:17389358
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q13501	Human	PMID:17389358
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q99523	Human	PMID:21102451
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q8K4V6	Human	PMID:21364532
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P22681	Human	PMID:21570973
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q9NZ52	Human	PMID:26446845
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q9P275	Human	PMID:27445338
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P05067-4	Human	PMID:28197073
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P08238	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P19174	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P27986	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:Q16288	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P27986	Human	PMID:8226808
Molecular Function	GO:0005515	protein binding	NTRK1	IPI	UniProtKB:P19174	Human	PMID:8384556
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	UniProtKB:Q80TN5	Mouse	MGI:MGI:5775247|PMID:26232532
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	UniProtKB:Q5RKR3	Mouse	MGI:MGI:4411944|PMID:19755105
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	PR:P25233	Mouse	PMID:16049186
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	PR:Q64337	Mouse	PMID:17389358
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	PR:Q9Z0W1	Mouse	PMID:16049186
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	PR:P63330	Mouse	PMID:19029245
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	MGI:MGI:2388481	Mouse	PMID:19029245
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	PR:O89053	Mouse	PMID:24270184
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	RGD:1307269	Rat	PMID:10691301|RGD:10003117
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	RGD:620395	Rat	PMID:10691301|RGD:10003117
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	UniProtKB:P62994	Rat	PMID:10748052|RGD:8553357
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	UniProtKB:F1M386	Rat	PMID:17724123|RGD:8554481
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	RGD:1304859	Rat	PMID:18768694|RGD:13504749
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	RGD:620845	Rat	PMID:19265194|RGD:5684374
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	UniProtKB:P07174	Rat	PMID:19549834|RGD:13432330
Molecular Function	GO:0005515	protein binding	Ntrk1	IPI	UniProtKB:A0A0G2JV04	Rat	PMID:26446845|RGD:11554955
Molecular Function	GO:0042803	protein homodimerization activity	NTRK1	IDA		Human	PMID:1281417
Molecular Function	GO:0042803	protein homodimerization activity	NTRK1	IDA		Human	PMID:17196528
Molecular Function	GO:0004713	protein tyrosine kinase activity	NTRK1	IDA		Human	PMID:2927393
Molecular Function	GO:0004713	protein tyrosine kinase activity	Ntrk1	IDA		Rat	PMID:19029245|RGD:8553977
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	NTRK1	IMP		Human	PMID:1281417
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	NTRK1	IDA		Human	PMID:15488758
Cellular Component	GO:0030424	axon	Ntrk1	IDA		Mouse	PMID:24270184
Cellular Component	GO:0030424	axon	Ntrk1	IDA		Rat	PMID:11134589|RGD:5684016
Cellular Component	GO:0009986	cell surface	Ntrk1	IDA		Mouse	PMID:24760869
Cellular Component	GO:0009986	cell surface	Ntrk1	IDA		Rat	PMID:16280603|RGD:5684774
Cellular Component	GO:0009986	cell surface	Ntrk1	IDA		Rat	PMID:19029245|RGD:8553977
Cellular Component	GO:0005737	cytoplasm	Ntrk1	IDA		Mouse	PMID:11551509
Cellular Component	GO:0005737	cytoplasm	Ntrk1	IDA		Mouse	PMID:10207144
Cellular Component	GO:0031410	cytoplasmic vesicle	Ntrk1	IDA		Rat	PMID:17625349|RGD:5684408
Cellular Component	GO:0030425	dendrite	Ntrk1	IDA		Rat	PMID:11134589|RGD:5684016
Cellular Component	GO:0005769	early endosome	Ntrk1	IDA		Mouse	PMID:24760869
Cellular Component	GO:0005769	early endosome	Ntrk1	IDA		Mouse	PMID:24270184
Cellular Component	GO:0005769	early endosome	Ntrk1	IDA		Rat	PMID:17724123|RGD:8554481
Cellular Component	GO:0005769	early endosome	Ntrk1	IDA		Rat	PMID:26446845|RGD:11554955
Cellular Component	GO:0005770	late endosome	Ntrk1	IDA		Mouse	PMID:24760869
Cellular Component	GO:0005770	late endosome	Ntrk1	IDA		Rat	PMID:17724123|RGD:8554481
Cellular Component	GO:0043025	neuronal cell body	Ntrk1	IDA		Rat	PMID:18395621|RGD:5684390
Cellular Component	GO:0005886	plasma membrane	NTRK1	IDA		Human	PMID:1281417
Cellular Component	GO:0005886	plasma membrane	NTRK1	IDA		Human	PMID:15488758
Cellular Component	GO:0005886	plasma membrane	NTRK1	IDA		Human	PMID:2927393
Cellular Component	GO:0005886	plasma membrane	Ntrk1	IDA		Rat	PMID:17724123|RGD:8554481
Cellular Component	GO:0005886	plasma membrane	Ntrk1	IDA		Rat	PMID:26446845|RGD:11554955
Cellular Component	GO:0032991	protein-containing complex	Ntrk1	IDA		Rat	PMID:17724123|RGD:8554481
Cellular Component	GO:0043235	receptor complex	NTRK1	IDA		Human	PMID:23382219
Cellular Component	GO:0055037	recycling endosome	Ntrk1	IDA		Rat	PMID:26446845|RGD:11554955
Biological Process	GO:0007568	aging	Ntrk1	IEP		Rat	PMID:21059364|RGD:5684347
Biological Process	GO:0007568	aging	Ntrk1	IEP		Rat	PMID:21559866|RGD:8693644
Biological Process	GO:0007411	axon guidance	Ntrk1	IMP		Rat	PMID:18344912|RGD:5684394
Biological Process	GO:0060385	axonogenesis involved in innervation	Ntrk1	IMP		Mouse	MGI:MGI:83009|PMID:8815902
Biological Process	GO:0030183	B cell differentiation	Ntrk1	IMP	MGI:MGI:3505767	Mouse	PMID:15459109
Biological Process	GO:0061368	behavioral response to formalin induced pain	Ntrk1	IMP		Mouse	PMID:24760869
Biological Process	GO:0071363	cellular response to growth factor stimulus	Ntrk1	IDA		Rat	PMID:19029245|RGD:8553977
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	NTRK1	IMP		Human	PMID:1281417
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Ntrk1	IDA		Mouse	PMID:24760869
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Ntrk1	IDA		Rat	PMID:17724123|RGD:8554481
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Ntrk1	IDA		Rat	PMID:26446845|RGD:11554955
Biological Process	GO:0071316	cellular response to nicotine	Ntrk1	IDA		Rat	PMID:16280603|RGD:5684774
Biological Process	GO:0007623	circadian rhythm	Ntrk1	IEP		Mouse	MGI:MGI:5503234|PMID:23785138
Biological Process	GO:0042742	defense response to bacterium	ntrk1	IMP	ZFIN:ZDB-MRPHLNO-150205-2	Zfish	PMID:25359976
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Ntrk1	IMP		Rat	PMID:20351485|RGD:5684352
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Ntrk1	IMP		Rat	PMID:20351485|RGD:5684352
Biological Process	GO:0090594	inflammatory response to wounding	ntrk1	IMP	ZFIN:ZDB-MRPHLNO-150205-2	Zfish	PMID:25359976
Biological Process	GO:0060384	innervation	Ntrk1	IMP		Mouse	PMID:24760869
Biological Process	GO:0007611	learning or memory	Ntrk1	IMP		Rat	PMID:18440710|RGD:5684387
Biological Process	GO:0042490	mechanoreceptor differentiation	Ntrk1	IMP	MGI:MGI:1888374	Mouse	PMID:15376326
Biological Process	GO:0008285	negative regulation of cell population proliferation	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ntrk1	IMP		Mouse	MGI:MGI:83009|PMID:8815902
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ntrk1	IGI	MGI:MGI:99702	Mouse	PMID:11731452
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ntrk1	IMP		Rat	PMID:19146958|RGD:5684376
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ntrk1	IMP		Rat	PMID:21541365|RGD:8554787
Biological Process	GO:1901215	negative regulation of neuron death	Ntrk1	IDA		Rat	PMID:20943663|RGD:5508695
Biological Process	GO:0038180	nerve growth factor signaling pathway	NTRK1	IMP		Human	PMID:1281417
Biological Process	GO:0038180	nerve growth factor signaling pathway	Ntrk1	IGI	MGI:MGI:1345961	Mouse	PMID:24270184
Biological Process	GO:0038180	nerve growth factor signaling pathway	Ntrk1	IDA		Mouse	PMID:7854358
Biological Process	GO:0038180	nerve growth factor signaling pathway	Ntrk1	IGI	MGI:MGI:97321	Mouse	PMID:24270184
Biological Process	GO:0038180	nerve growth factor signaling pathway	Ntrk1	IDA		Rat	PMID:17724123|RGD:8554481
Biological Process	GO:0007399	nervous system development	Ntrk1	IDA		Mouse	PMID:12810599
Biological Process	GO:0051402	neuron apoptotic process	Ntrk1	IGI	MGI:MGI:99702	Mouse	PMID:11731452
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0002446	neutrophil mediated immunity	ntrk1	IMP	ZFIN:ZDB-MRPHLNO-150205-2	Zfish	PMID:25359976
Biological Process	GO:0021553	olfactory nerve development	Ntrk1	IEP		Rat	PMID:8778281|RGD:5684018
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	NTRK1	IMP		Human	PMID:1281417
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	NTRK1	IDA		Human	PMID:2927393
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0043547	positive regulation of GTPase activity	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0010976	positive regulation of neuron projection development	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0043068	positive regulation of programmed cell death	Ntrk1	IDA		Rat	PMID:20811452|RGD:8554835
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Ntrk1	IDA		Rat	PMID:19036963|RGD:8553786
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0051965	positive regulation of synapse assembly	Ntrk1	IDA		Mouse	PMID:24613359
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Ntrk1	IMP		Rat	PMID:21550171|RGD:5144124
Biological Process	GO:0010623	programmed cell death involved in cell development	Ntrk1	IDA		Rat	PMID:20811452|RGD:8554835
Biological Process	GO:0046777	protein autophosphorylation	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0046777	protein autophosphorylation	Ntrk1	IDA		Rat	PMID:19029245|RGD:8553977
Biological Process	GO:0006468	protein phosphorylation	NTRK1	IDA		Human	PMID:15488758
Biological Process	GO:0006468	protein phosphorylation	Ntrk1	IDA		Mouse	PMID:11877420
Biological Process	GO:0014823	response to activity	Ntrk1	IDA		Rat	PMID:19800940|RGD:5684356
Biological Process	GO:0048678	response to axon injury	Ntrk1	IEP		Rat	PMID:21456016|RGD:5684341
Biological Process	GO:0051602	response to electrical stimulus	Ntrk1	IDA		Rat	PMID:19596387|RGD:5684361
Biological Process	GO:0045471	response to ethanol	Ntrk1	IEP		Rat	PMID:17316397|RGD:5684413
Biological Process	GO:0051599	response to hydrostatic pressure	Ntrk1	IEP		Rat	PMID:18817846|RGD:5684379
Biological Process	GO:0035094	response to nicotine	Ntrk1	IDA		Rat	PMID:20056136|RGD:5684354
Biological Process	GO:0031667	response to nutrient levels	Ntrk1	IDA		Rat	PMID:17582385|RGD:5684410
Biological Process	GO:0009314	response to radiation	Ntrk1	IEP		Rat	PMID:21431457|RGD:5684342
Biological Process	GO:0009410	response to xenobiotic stimulus	Ntrk1	IDA		Rat	PMID:20059802|RGD:5684353
Biological Process	GO:0019233	sensory perception of pain	Ntrk1	IMP		Rat	PMID:17667845|RGD:5144120
Biological Process	GO:0060009	Sertoli cell development	Ntrk1	IMP		Rat	PMID:18660385|RGD:5684384
Biological Process	GO:0048485	sympathetic nervous system development	Ntrk1	IMP		Mouse	MGI:MGI:83009|PMID:8815902

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern