Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ntrk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NTRK2
- Mouse genes Ntrk2
- Rat genes Ntrk2
- Zfish genes ntrk2a,ntrk2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ntrk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	Ntrk2	IDA		Mouse	MGI:MGI:893826\|PMID:1645620
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	Ntrk2	IDA		Rat	PMID:1645620\|RGD:8554777
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	Ntrk2	IDA		Rat	PMID:16477614\|RGD:1626131
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	Ntrk2	IMP		Rat	PMID:16983663\|RGD:1626130
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	NTRK2	IMP		Human	PMID:15494731
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	Ntrk2	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	Ntrk2	IDA		Rat	PMID:1645620\|RGD:8554777
Molecular Function	GO:0060175	brain-derived neurotrophic factor receptor activity	Ntrk2	IDA		Rat	PMID:8627351\|RGD:8554094
Molecular Function	GO:0043121	neurotrophin binding	NTRK2	IDA		Human	PMID:11738045
Molecular Function	GO:0043121	neurotrophin binding	Ntrk2	IDA		Mouse	MGI:MGI:893826\|PMID:1645620
Molecular Function	GO:0043121	neurotrophin binding	Ntrk2	IDA		Rat	PMID:1645620\|RGD:8554777
Molecular Function	GO:0005030	neurotrophin receptor activity	Ntrk2	IDA		Rat	PMID:16477614\|RGD:1626131
Molecular Function	GO:0005030	neurotrophin receptor activity	Ntrk2	IMP		Rat	PMID:16983663\|RGD:1626130
Molecular Function	GO:0002020	protease binding	NTRK2	IPI	UniProtKB:P49768	Human	PMID:26094765
Molecular Function	GO:0002020	protease binding	NTRK2	IPI	UniProtKB:Q92542	Human	PMID:26094765
Molecular Function	GO:0005515	protein binding	NTRK2	IPI	UniProtKB:Q03114	Human	PMID:17341134
Molecular Function	GO:0005515	protein binding	NTRK2	IPI	UniProtKB:Q16288	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q62108	Mouse	MGI:MGI:5474131\|PMID:23424281
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q99LI8	Mouse	MGI:MGI:4840150\|PMID:20956301
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q6PHU5	Mouse	MGI:MGI:5560429\|PMID:24355921
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:O08543	Mouse	MGI:MGI:5426777\|PMID:19036963
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q6PHU5	Mouse	MGI:MGI:4946148\|PMID:21102451
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:P35235\|UniProtKB:Q8K4V6	Mouse	MGI:MGI:4949042\|PMID:21364532
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q8K3H0	Mouse	MGI:MGI:5825424\|PMID:21849472
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q60610	Mouse	MGI:MGI:5306304\|PMID:16801538
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:P98083\|UniProtKB:Q62077	Mouse	MGI:MGI:3772008\|PMID:12367511
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	PR:P20181	Mouse	PMID:11684666
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	PR:Q3UA06	Mouse	PMID:11591653
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	PR:Q9Z0G0	Mouse	PMID:16819522
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	PR:Q8K019	Mouse	PMID:11591653
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q03114	Rat	PMID:17341134\|RGD:13432345
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	RGD:2625	Rat	PMID:18957540\|RGD:2302981
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q04631	Rat	PMID:18957540\|RGD:2302981
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:P06536	Rat	PMID:19126684\|RGD:13432268
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q8K4V6	Rat	PMID:21364532\|RGD:8554762
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:E9PSK7	Rat	PMID:21775604\|RGD:13673858
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:P37285	Rat	PMID:21775604\|RGD:13673858
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q9ESN9	Rat	PMID:21775604\|RGD:13673858
Molecular Function	GO:0005515	protein binding	Ntrk2	IPI	UniProtKB:Q5M824	Rat	PMID:9582017\|RGD:8554617
Molecular Function	GO:0042803	protein homodimerization activity	Ntrk2	IDA		Rat	PMID:8627351\|RGD:8554094
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Ntrk2	IPI	RGD:1307455	Rat	PMID:16801538\|RGD:10043330
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Ntrk2	IMP		Rat	PMID:17447135\|RGD:1626134
Cellular Component	GO:0030424	axon	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0030424	axon	Ntrk2	IDA		Rat	PMID:21775604\|RGD:13673858
Cellular Component	GO:0043679	axon terminus	Ntrk2	IDA		Rat	PMID:18582438\|RGD:2303068
Cellular Component	GO:0009986	cell surface	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0005737	cytoplasm	Ntrk2	IDA		Rat	PMID:17640634\|RGD:8655603
Cellular Component	GO:0005829	cytosol	Ntrk2	IDA		Mouse	PMID:11083466
Cellular Component	GO:0030425	dendrite	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0030425	dendrite	Ntrk2	IDA		Rat	PMID:21775604\|RGD:13673858
Cellular Component	GO:0043197	dendritic spine	Ntrk2	IDA		Rat	PMID:18582438\|RGD:2303068
Cellular Component	GO:0043197	dendritic spine	Ntrk2	IDA		Rat	PMID:25632160\|RGD:12050128
Cellular Component	GO:0005769	early endosome	Ntrk2	IDA		Mouse	MGI:MGI:5825424\|PMID:21849472
Cellular Component	GO:0005768	endosome	Ntrk2	IDA		Mouse	PMID:24035762
Cellular Component	GO:0060076	excitatory synapse	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0098978	glutamatergic synapse	Ntrk2	IDA		Rat	PMID:10679783\|RGD:155230712
Cellular Component	GO:0098978	glutamatergic synapse	Ntrk2	IDA		Rat	PMID:25632160\|RGD:12050128
Cellular Component	GO:0098978	glutamatergic synapse	Ntrk2	IMP		Rat	PMID:25632160\|RGD:12050128
Cellular Component	GO:0030426	growth cone	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0043025	neuronal cell body	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0043204	perikaryon	Ntrk2	IDA		Rat	PMID:16626872\|RGD:8655644
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ntrk2	IDA		Rat	PMID:21775604\|RGD:13673858
Cellular Component	GO:0005886	plasma membrane	NTRK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	NTRK2	IDA		Human	PMID:15494731
Cellular Component	GO:0005886	plasma membrane	Ntrk2	IDA		Mouse	PMID:12798291
Cellular Component	GO:0005886	plasma membrane	Ntrk2	IDA		Mouse	PMID:12646573
Cellular Component	GO:0005886	plasma membrane	Ntrk2	IDA		Rat	PMID:1645620\|RGD:8554777
Cellular Component	GO:0005886	plasma membrane	Ntrk2	IDA		Rat	PMID:17079678\|RGD:1626129
Cellular Component	GO:0098794	postsynapse	Ntrk2	IDA		Rat	PMID:25632160\|RGD:12050128
Cellular Component	GO:0098794	postsynapse	Ntrk2	IMP		Rat	PMID:25632160\|RGD:12050128
Cellular Component	GO:0014069	postsynaptic density	Ntrk2	IDA		Mouse	MGI:MGI:3531596\|PMID:15601948
Cellular Component	GO:0014069	postsynaptic density	Ntrk2	IDA		Mouse	PMID:24069373
Cellular Component	GO:0014069	postsynaptic density	Ntrk2	IDA		Rat	PMID:11226670\|RGD:5147998
Cellular Component	GO:0014069	postsynaptic density	Ntrk2	IDA		Rat	PMID:16477614\|RGD:1626131
Cellular Component	GO:0045211	postsynaptic membrane	Ntrk2	IDA		Rat	PMID:10679783\|RGD:155230712
Cellular Component	GO:0048786	presynaptic active zone	Ntrk2	IDA		Rat	PMID:16477614\|RGD:1626131
Cellular Component	GO:0043235	receptor complex	NTRK2	IDA		Human	PMID:23382219
Cellular Component	GO:0005791	rough endoplasmic reticulum	Ntrk2	IDA		Rat	PMID:16626872\|RGD:8655644
Cellular Component	GO:0045202	synapse	Ntrk2	IDA		Mouse	MGI:MGI:5661287\|PMID:24991961
Cellular Component	GO:0043195	terminal bouton	Ntrk2	IDA		Mouse	PMID:16819522
Biological Process	GO:0007568	aging	Ntrk2	IEP		Rat	PMID:21951697\|RGD:5684924
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	NTRK2	IMP		Human	PMID:15494731
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Ntrk2	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Ntrk2	IMP		Rat	PMID:15654844\|RGD:1626132
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Ntrk2	IDA		Rat	PMID:1645620\|RGD:8554777
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Ntrk2	IDA		Rat	PMID:8627351\|RGD:8554094
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	Ntrk2	IMP		Mouse	MGI:MGI:5306316\|PMID:14603320
Biological Process	GO:0071230	cellular response to amino acid stimulus	Ntrk2	IDA		Mouse	PMID:25542970
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	Ntrk2	IEP		Rat	PMID:21958434\|RGD:8657122
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Ntrk2	IEP		Rat	PMID:21958434\|RGD:8657122
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Ntrk2	IEP		Rat	PMID:21958434\|RGD:8657122
Biological Process	GO:0021954	central nervous system neuron development	Ntrk2	IMP		Mouse	MGI:MGI:1343962\|PMID:8402890
Biological Process	GO:0021987	cerebral cortex development	Ntrk2	IMP		Mouse	MGI:MGI:3776308\|PMID:15372074
Biological Process	GO:0007623	circadian rhythm	Ntrk2	IEP		Mouse	MGI:MGI:5503234\|PMID:23785138
Biological Process	GO:0007631	feeding behavior	Ntrk2	IMP	MGI:MGI:2384391	Mouse	PMID:12796784
Biological Process	GO:0014047	glutamate secretion	Ntrk2	IPI	UniProtKB:P21237	Mouse	PMID:16819522
Biological Process	GO:0006954	inflammatory response	Ntrk2	IEP		Rat	PMID:21958434\|RGD:8657122
Biological Process	GO:0048882	lateral line development	ntrk2b	IMP	ZFIN:ZDB-MRPHLNO-150604-4	Zfish	PMID:25751404
Biological Process	GO:0007612	learning	Ntrk2	IMP		Mouse	MGI:MGI:1346961\|PMID:10571233
Biological Process	GO:0007616	long-term memory	Ntrk2	IDA		Rat	PMID:21136519\|RGD:5684780
Biological Process	GO:0060291	long-term synaptic potentiation	Ntrk2	IMP		Mouse	MGI:MGI:3772008\|PMID:12367511
Biological Process	GO:0042490	mechanoreceptor differentiation	Ntrk2	IMP	MGI:MGI:1857814	Mouse	PMID:15376326
Biological Process	GO:0022011	myelination in peripheral nervous system	Ntrk2	IGI	MGI:MGI:97385	Mouse	PMID:20553714
Biological Process	GO:0022011	myelination in peripheral nervous system	Ntrk2	IGI	MGI:MGI:97631	Mouse	PMID:20553714
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	NTRK2	IGI	UniProtKB:P05067-4	Human	PMID:26094765
Biological Process	GO:2000811	negative regulation of anoikis	Ntrk2	IDA		Mouse	MGI:MGI:5306312\|PMID:15329723
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Ntrk2	IMP		Rat	PMID:10985347\|RGD:8553408
Biological Process	GO:0048883	neuromast primordium migration	ntrk2b	IMP	ZFIN:ZDB-MRPHLNO-150604-4	Zfish	PMID:25751404
Biological Process	GO:0030182	neuron differentiation	Ntrk2	IMP		Mouse	MGI:MGI:3776308\|PMID:15372074
Biological Process	GO:0001764	neuron migration	Ntrk2	IMP		Mouse	MGI:MGI:3776308\|PMID:15372074
Biological Process	GO:0019227	neuronal action potential propagation	Ntrk2	IGI	MGI:MGI:97385	Mouse	PMID:20553714
Biological Process	GO:0019227	neuronal action potential propagation	Ntrk2	IGI	MGI:MGI:97631	Mouse	PMID:20553714
Biological Process	GO:0048709	oligodendrocyte differentiation	Ntrk2	IMP		Mouse	MGI:MGI:3776308\|PMID:15372074
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Ntrk2	IMP		Mouse	PMID:23878391
Biological Process	GO:0048935	peripheral nervous system neuron development	Ntrk2	IMP		Mouse	MGI:MGI:1343962\|PMID:8402890
Biological Process	GO:0050772	positive regulation of axonogenesis	Ntrk2	IMP		Rat	PMID:10985347\|RGD:8553408
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ntrk2	IDA		Rat	PMID:9582017\|RGD:8554617
Biological Process	GO:0010628	positive regulation of gene expression	Ntrk2	IMP		Mouse	MGI:MGI:3772008\|PMID:12367511
Biological Process	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	Ntrk2	IGI	UniProtKB:P23363	Rat	PMID:23878391\|RGD:10047172
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ntrk2	IMP		Rat	PMID:10985347\|RGD:8553408
Biological Process	GO:0010976	positive regulation of neuron projection development	Ntrk2	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Ntrk2	IMP		Mouse	PMID:23878391
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Ntrk2	IMP		Rat	PMID:10985347\|RGD:8553408
Biological Process	GO:0051965	positive regulation of synapse assembly	Ntrk2	IDA		Mouse	PMID:24613359
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	Ntrk2	IMP		Rat	PMID:16983663\|RGD:1626130
Biological Process	GO:0046777	protein autophosphorylation	Ntrk2	IMP		Rat	PMID:17447135\|RGD:1626134
Biological Process	GO:0046777	protein autophosphorylation	Ntrk2	IDA		Rat	PMID:9582017\|RGD:8554617
Biological Process	GO:0050773	regulation of dendrite development	Ntrk2	IMP		Rat	PMID:15654844\|RGD:1626132
Biological Process	GO:0043087	regulation of GTPase activity	Ntrk2	IDA		Mouse	MGI:MGI:5306304\|PMID:16801538
Biological Process	GO:0043408	regulation of MAPK cascade	Ntrk2	IDA		Rat	PMID:9582017\|RGD:8554617
Biological Process	GO:0019222	regulation of metabolic process	Ntrk2	IMP	MGI:MGI:2384391	Mouse	PMID:12796784
Biological Process	GO:0046928	regulation of neurotransmitter secretion	Ntrk2	IDA		Rat	PMID:16477614\|RGD:1626131
Biological Process	GO:0051896	regulation of protein kinase B signaling	Ntrk2	IMP		Mouse	MGI:MGI:3776308\|PMID:15372074
Biological Process	GO:0010996	response to auditory stimulus	Ntrk2	IEP		Rat	PMID:21034795\|RGD:5684781
Biological Process	GO:0009416	response to light stimulus	Ntrk2	IEP		Rat	PMID:17640634\|RGD:8655603
Biological Process	GO:0060041	retina development in camera-type eye	Ntrk2	IMP		Mouse	PMID:25542970
Biological Process	GO:0046548	retinal rod cell development	Ntrk2	IMP	MGI:MGI:3039928	Mouse	PMID:10516311
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Ntrk2	IDA		Mouse	PMID:24991961
Biological Process	GO:0099183	trans-synaptic signaling by BDNF, modulating synaptic transmission	Ntrk2	IMP		Mouse	PMID:24991961
Biological Process	GO:0099551	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	Ntrk2	IMP		Mouse	MGI:MGI:5661287\|PMID:24991961
Biological Process	GO:0001570	vasculogenesis	Ntrk2	IMP	MGI:MGI:1857814	Mouse	PMID:16264195

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.