Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NUCKS1
  • Mouse genes Nucks1
  • Rat genes Nucks1
  • Zfish genes nucks1a,nucks1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nucks1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	NUCKS1	IDA		Human	PMID:26323318
Molecular Function	GO:0140297	DNA-binding transcription factor binding	NUCKS1	IPI	UniProtKB:P04608	Human	PMID:25116364
Molecular Function	GO:0003690	double-stranded DNA binding	NUCKS1	IDA		Human	PMID:26323318
Molecular Function	GO:0003723	RNA binding	NUCKS1	HDA		Human	PMID:22681889
Molecular Function	GO:0003697	single-stranded DNA binding	Nucks1	IDA		Rat	PMID:1627131|RGD:11344951
Molecular Function	GO:0003713	transcription coactivator activity	NUCKS1	IDA		Human	PMID:25116364
Cellular Component	GO:0000785	chromatin	NUCKS1	IDA		Human	PMID:26323318
Cellular Component	GO:0000785	chromatin	Nucks1	IDA		Mouse	MGI:MGI:5695791|PMID:26205492
Cellular Component	GO:0005737	cytoplasm	NUCKS1	IDA		Human	PMID:17604136
Cellular Component	GO:0005737	cytoplasm	Nucks1	IDA		Mouse	MGI:MGI:5785001|PMID:3000779
Cellular Component	GO:0005737	cytoplasm	Nucks1	IDA		Rat	PMID:12413487|RGD:1298022
Cellular Component	GO:0005730	nucleolus	NUCKS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NUCKS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NUCKS1	IDA		Human	PMID:11298763
Cellular Component	GO:0005634	nucleus	NUCKS1	IDA		Human	PMID:17604136
Cellular Component	GO:0005634	nucleus	NUCKS1	IDA		Human	PMID:25116364
Cellular Component	GO:0005634	nucleus	NUCKS1	IDA		Human	PMID:26323318
Cellular Component	GO:0005634	nucleus	Nucks1	IDA		Mouse	MGI:MGI:5785001|PMID:3000779
Cellular Component	GO:0005634	nucleus	Nucks1	IDA		Mouse	PMID:11298763
Cellular Component	GO:0005634	nucleus	Nucks1	IDA		Rat	PMID:12413487|RGD:1298022
Biological Process	GO:0071481	cellular response to X-ray	NUCKS1	IMP		Human	PMID:26323318
Biological Process	GO:0006325	chromatin organization	Nucks1	IMP		Mouse	MGI:MGI:5576396|PMID:24931609
Biological Process	GO:0006325	chromatin organization	Nucks1	IMP		Mouse	MGI:MGI:5695791|PMID:26205492
Biological Process	GO:0000724	double-strand break repair via homologous recombination	NUCKS1	IMP		Human	PMID:26323318
Biological Process	GO:0042593	glucose homeostasis	Nucks1	IMP	MGI:MGI:5634908	Mouse	PMID:24931609
Biological Process	GO:0036297	interstrand cross-link repair	NUCKS1	IMP		Human	PMID:26323318
Biological Process	GO:0001678	intracellular glucose homeostasis	Nucks1	IMP		Mouse	MGI:MGI:5695791|PMID:26205492
Biological Process	GO:1990968	modulation by host of RNA binding by virus	NUCKS1	IMP		Human	PMID:25116364
Biological Process	GO:0044827	modulation by host of viral genome replication	NUCKS1	IMP		Human	PMID:25116364
Biological Process	GO:1990969	modulation by host of viral RNA-binding transcription factor activity	NUCKS1	IGI	UniProtKB:P04608	Human	PMID:25116364
Biological Process	GO:0044829	positive regulation by host of viral genome replication	NUCKS1	IMP		Human	PMID:25116364
Biological Process	GO:0043923	positive regulation by host of viral transcription	NUCKS1	IGI	UniProtKB:P04608	Human	PMID:25116364
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Nucks1	IMP		Mouse	PMID:24931609
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Nucks1	IDA		Mouse	MGI:MGI:5576396|PMID:24931609
Biological Process	GO:0006275	regulation of DNA replication	NUCKS1	IMP		Human	PMID:26323318
Biological Process	GO:0060382	regulation of DNA strand elongation	NUCKS1	IMP		Human	PMID:26323318
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	Nucks1	IMP		Mouse	MGI:MGI:5695791|PMID:26205492
Biological Process	GO:0031297	replication fork processing	NUCKS1	IDA		Human	PMID:26323318

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern