Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NUMA1
  • Mouse genes Numa1
  • Rat genes Numa1
  • Zfish genes numa1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Numa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097718	disordered domain specific binding	NUMA1	IMP		Human	PMID:20109190
Molecular Function	GO:0070840	dynein complex binding	NUMA1	IDA		Human	PMID:10811826
Molecular Function	GO:0070840	dynein complex binding	NUMA1	IDA		Human	PMID:17172455
Molecular Function	GO:0070840	dynein complex binding	NUMA1	IDA		Human	PMID:22327364
Molecular Function	GO:0070840	dynein complex binding	NUMA1	IDA		Human	PMID:23027904
Molecular Function	GO:0070840	dynein complex binding	NUMA1	IDA		Human	PMID:26195665
Molecular Function	GO:0008017	microtubule binding	NUMA1	IDA		Human	PMID:11956313
Molecular Function	GO:0008017	microtubule binding	NUMA1	IDA		Human	PMID:12445386
Molecular Function	GO:0008017	microtubule binding	NUMA1	IDA		Human	PMID:27462074
Molecular Function	GO:0008017	microtubule binding	Numa1	IDA		Rat	PMID:15265698|RGD:1599100
Molecular Function	GO:0051011	microtubule minus-end binding	NUMA1	IDA		Human	PMID:26765568
Molecular Function	GO:0051010	microtubule plus-end binding	NUMA1	IDA		Human	PMID:26765568
Molecular Function	GO:0035091	phosphatidylinositol binding	NUMA1	IDA		Human	PMID:24371089
Molecular Function	GO:0035091	phosphatidylinositol binding	NUMA1	IDA		Human	PMID:24996901
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q14683	Human	PMID:11590136
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q9UQE7	Human	PMID:11590136
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:11781568
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:O95271	Human	PMID:12080061
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q9H2K2	Human	PMID:12080061
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:12445386
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P63096	Human	PMID:15537540
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:15537540
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:O95271	Human	PMID:16076287
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P78406	Human	PMID:17172455
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P11171	Human	PMID:20109190
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:21816348
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q9H2K2	Human	PMID:22153077
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:22327364
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:O43491	Human	PMID:23870127
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P11171	Human	PMID:23870127
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:O43491	Human	PMID:24996901
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P11171	Human	PMID:24996901
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q2TAC2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q53SE7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q14974	Human	PMID:26195665
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q15018	Human	PMID:26195665
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:27462074
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:Q96R06	Human	PMID:27462074
Molecular Function	GO:0005515	protein binding	NUMA1	IPI	UniProtKB:O95271	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Numa1	IPI	UniProtKB:Q9CWU5	Mouse	MGI:MGI:6716962|PMID:25936915
Molecular Function	GO:0005515	protein binding	numa1	IPI	ZFIN:ZDB-GENE-010319-1	Zfish	PMID:21074723
Molecular Function	GO:0019904	protein domain specific binding	NUMA1	IPI	UniProtKB:P81274	Human	PMID:22074847
Molecular Function	GO:0044877	protein-containing complex binding	NUMA1	IDA		Human	PMID:11590136
Molecular Function	GO:0015631	tubulin binding	NUMA1	IDA		Human	PMID:11956313
Cellular Component	GO:0045177	apical part of cell	Numa1	IDA		Mouse	PMID:21385765
Cellular Component	GO:0005938	cell cortex	NUMA1	IDA		Human	PMID:23783028
Cellular Component	GO:0005938	cell cortex	NUMA1	IDA		Human	PMID:23870127
Cellular Component	GO:0005938	cell cortex	numa1	IGI	ZFIN:ZDB-GENE-990415-223	Zfish	PMID:21074723
Cellular Component	GO:0099738	cell cortex region	NUMA1	IDA		Human	PMID:21816348
Cellular Component	GO:0099738	cell cortex region	NUMA1	IDA		Human	PMID:22327364
Cellular Component	GO:0099738	cell cortex region	NUMA1	IDA		Human	PMID:23921553
Cellular Component	GO:0099738	cell cortex region	NUMA1	IDA		Human	PMID:24371089
Cellular Component	GO:0099738	cell cortex region	NUMA1	IDA		Human	PMID:24996901
Cellular Component	GO:0099738	cell cortex region	Numa1	IDA		Mouse	MGI:MGI:5754878|PMID:26765568
Cellular Component	GO:0005813	centrosome	NUMA1	IDA		Human	PMID:25657325
Cellular Component	GO:0005813	centrosome	NUMA1	IDA		Human	PMID:26562023
Cellular Component	GO:0005813	centrosome	NUMA1	IDA		Human	PMID:26765568
Cellular Component	GO:0055028	cortical microtubule	NUMA1	IDA		Human	PMID:26765568
Cellular Component	GO:0005737	cytoplasm	numa1	IDA		Zfish	PMID:21074723
Cellular Component	GO:1905720	cytoplasmic microtubule bundle	NUMA1	IDA		Human	PMID:12445386
Cellular Component	GO:0005829	cytosol	NUMA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Numa1	IDA		Rat	PMID:10659681|RGD:1598683
Cellular Component	GO:0070062	extracellular exosome	NUMA1	HDA		Human	PMID:18570454
Cellular Component	GO:0019897	extrinsic component of plasma membrane	NUMA1	IDA		Human	PMID:24371089
Cellular Component	GO:0019897	extrinsic component of plasma membrane	NUMA1	IDA		Human	PMID:24996901
Cellular Component	GO:0097575	lateral cell cortex	Numa1	IMP		Mouse	MGI:MGI:5882149|PMID:26766442
Cellular Component	GO:0097427	microtubule bundle	NUMA1	IDA		Human	PMID:11956313
Cellular Component	GO:0036449	microtubule minus-end	NUMA1	IDA		Human	PMID:26765568
Cellular Component	GO:0035371	microtubule plus-end	NUMA1	IDA		Human	PMID:26765568
Cellular Component	GO:0072686	mitotic spindle	NUMA1	IDA		Human	PMID:10811826
Cellular Component	GO:0072686	mitotic spindle	NUMA1	IDA		Human	PMID:26562023
Cellular Component	GO:0072686	mitotic spindle	NUMA1	IDA		Human	PMID:27462074
Cellular Component	GO:0061673	mitotic spindle astral microtubule	NUMA1	IDA		Human	PMID:10811826
Cellular Component	GO:0061673	mitotic spindle astral microtubule	NUMA1	IDA		Human	PMID:12445386
Cellular Component	GO:0061673	mitotic spindle astral microtubule	NUMA1	IDA		Human	PMID:1541636
Cellular Component	GO:0061673	mitotic spindle astral microtubule	NUMA1	IDA		Human	PMID:24996901
Cellular Component	GO:0061673	mitotic spindle astral microtubule	NUMA1	IDA		Human	PMID:26562023
Cellular Component	GO:1990023	mitotic spindle midzone	NUMA1	IDA		Human	PMID:10811826
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:10811826
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:11781568
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:11956313
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:1541636
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:16076287
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IMP		Human	PMID:17172455
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:21816348
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:22327364
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:23783028
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:23870127
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:24371089
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:24996901
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:25657325
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:26195665
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:27462074
Cellular Component	GO:0097431	mitotic spindle pole	NUMA1	IDA		Human	PMID:7962183
Cellular Component	GO:0097431	mitotic spindle pole	Numa1	IDA		Mouse	MGI:MGI:5754878|PMID:26765568
Cellular Component	GO:0043025	neuronal cell body	Numa1	IDA		Rat	PMID:10659681|RGD:1598683
Cellular Component	GO:0016363	nuclear matrix	NUMA1	IDA		Human	PMID:11956313
Cellular Component	GO:0016363	nuclear matrix	NUMA1	IDA		Human	PMID:7962183
Cellular Component	GO:0016363	nuclear matrix	Numa1	IDA		Mouse	PMID:11092755
Cellular Component	GO:0016363	nuclear matrix	Numa1	IDA		Rat	PMID:12243746|RGD:1598684
Cellular Component	GO:0005654	nucleoplasm	NUMA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NUMA1	IDA		Human	PMID:10811826
Cellular Component	GO:0005634	nucleus	NUMA1	IDA		Human	PMID:1541636
Cellular Component	GO:0005634	nucleus	NUMA1	IDA		Human	PMID:23921553
Cellular Component	GO:0005634	nucleus	NUMA1	IDA		Human	PMID:27462074
Cellular Component	GO:0005634	nucleus	Numa1	IDA		Rat	PMID:10659681|RGD:1598683
Cellular Component	GO:0032991	protein-containing complex	NUMA1	IMP		Human	PMID:20109190
Cellular Component	GO:0032991	protein-containing complex	NUMA1	IDA		Human	PMID:22074847
Cellular Component	GO:0005819	spindle	numa1	IGI	ZFIN:ZDB-GENE-990415-223	Zfish	PMID:21074723
Cellular Component	GO:0005876	spindle microtubule	NUMA1	IDA		Human	PMID:1541636
Cellular Component	GO:0005876	spindle microtubule	Numa1	IDA		Rat	PMID:15265698|RGD:1599100
Cellular Component	GO:0000922	spindle pole	NUMA1	IDA		Human	PMID:14718566
Cellular Component	GO:0000922	spindle pole	NUMA1	IDA		Human	PMID:18331714
Cellular Component	GO:0000922	spindle pole	NUMA1	IDA		Human	PMID:23921553
Cellular Component	GO:0000922	spindle pole	Numa1	IDA		Rat	PMID:15265698|RGD:1599100
Cellular Component	GO:0031616	spindle pole centrosome	NUMA1	IDA		Human	PMID:10811826
Biological Process	GO:0055048	anastral spindle assembly	NUMA1	IMP		Human	PMID:25657325
Biological Process	GO:0030953	astral microtubule organization	NUMA1	IDA		Human	PMID:12445386
Biological Process	GO:0030953	astral microtubule organization	NUMA1	IMP		Human	PMID:12445386
Biological Process	GO:0000132	establishment of mitotic spindle orientation	NUMA1	IDA		Human	PMID:21816348
Biological Process	GO:0000132	establishment of mitotic spindle orientation	NUMA1	IMP		Human	PMID:24996901
Biological Process	GO:0000132	establishment of mitotic spindle orientation	NUMA1	IMP		Human	PMID:26765568
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Numa1	IMP		Mouse	MGI:MGI:5754878|PMID:26765568
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Numa1	IMP		Mouse	PMID:21385765
Biological Process	GO:0060487	lung epithelial cell differentiation	Numa1	IMP		Mouse	PMID:21385765
Biological Process	GO:0051321	meiotic cell cycle	Numa1	IEP		Rat	PMID:15265698|RGD:1599100
Biological Process	GO:0001578	microtubule bundle formation	NUMA1	IMP		Human	PMID:12445386
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	Numa1	IMP		Mouse	MGI:MGI:5754878|PMID:26765568
Biological Process	GO:0051984	positive regulation of chromosome segregation	NUMA1	IMP		Human	PMID:24371089
Biological Process	GO:1905820	positive regulation of chromosome separation	NUMA1	IMP		Human	PMID:23921553
Biological Process	GO:0051798	positive regulation of hair follicle development	Numa1	IMP		Mouse	MGI:MGI:5754878|PMID:26765568
Biological Process	GO:0032388	positive regulation of intracellular transport	NUMA1	IMP		Human	PMID:27462074
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	Numa1	IMP		Mouse	MGI:MGI:5754878|PMID:26765568
Biological Process	GO:0031116	positive regulation of microtubule polymerization	NUMA1	IMP		Human	PMID:12445386
Biological Process	GO:1902846	positive regulation of mitotic spindle elongation	NUMA1	IMP		Human	PMID:23921553
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	NUMA1	IMP		Human	PMID:22327364
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	NUMA1	IMP		Human	PMID:23027904
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	NUMA1	IMP		Human	PMID:23870127
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	NUMA1	IMP		Human	PMID:23921553
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	NUMA1	IMP		Human	PMID:24371089
Biological Process	GO:1904778	positive regulation of protein localization to cell cortex	NUMA1	IMP		Human	PMID:24996901
Biological Process	GO:1902365	positive regulation of protein localization to spindle pole body	NUMA1	IDA		Human	PMID:16076287
Biological Process	GO:1905832	positive regulation of spindle assembly	NUMA1	IMP		Human	PMID:27462074
Biological Process	GO:0090235	regulation of metaphase plate congression	NUMA1	IMP		Human	PMID:27462074
Biological Process	GO:0060236	regulation of mitotic spindle organization	NUMA1	IMP		Human	PMID:11956313
Biological Process	GO:0060236	regulation of mitotic spindle organization	NUMA1	IMP		Human	PMID:17172455
Biological Process	GO:0060236	regulation of mitotic spindle organization	NUMA1	IMP		Human	PMID:23027904
Biological Process	GO:0060236	regulation of mitotic spindle organization	NUMA1	IMP		Human	PMID:24371089
Biological Process	GO:0060236	regulation of mitotic spindle organization	NUMA1	IDA		Human	PMID:26195665

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern