Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Numb

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes NUMB
- Mouse genes Numb
- Rat genes Numb
- Zfish genes numb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Numb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045294	alpha-catenin binding	Numb	IPI	PR:P26231	Mouse	PMID:17589506
Molecular Function	GO:0008013	beta-catenin binding	Numb	IPI	PR:Q02248	Mouse	PMID:17589506
Molecular Function	GO:0045296	cadherin binding	NUMB	HDA		Human	PMID:25468996
Molecular Function	GO:0045296	cadherin binding	Numb	IPI	PR:P15116	Mouse	PMID:17589506
Molecular Function	GO:0045296	cadherin binding	Numb	IPI	PR:P09803	Mouse	PMID:17589506
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:P04637	Human	PMID:18172499
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:Q00987	Human	PMID:18172499
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:P42566	Human	PMID:23211419
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:Q96D71	Human	PMID:23211419
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:Q9UHC9	Human	PMID:24336247
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:P35222	Human	PMID:24561623
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:P42566	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:Q00987	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	NUMB	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Numb	IPI	UniProtKB:P42566\|UniProtKB:P42566\|UniProtKB:Q96D71\|UniProtKB:Q96D71	Mouse	MGI:MGI:5586791\|PMID:23211419
Molecular Function	GO:0005515	protein binding	Numb	IPI	UniProtKB:P08151\|UniProtKB:Q96J02	Mouse	MGI:MGI:5285151\|PMID:20818436
Molecular Function	GO:0005515	protein binding	Numb	IPI	UniProtKB:P09803	Mouse	MGI:MGI:3763347\|PMID:17174898
Molecular Function	GO:0005515	protein binding	Numb	IPI	UniProtKB:P51906	Mouse	PMID:27358480
Molecular Function	GO:0005515	protein binding	Numb	IPI	UniProtKB:P43005	Mouse	PMID:27358480
Molecular Function	GO:0005515	protein binding	Numb	IPI	PR:Q91XL2	Mouse	PMID:11922143
Molecular Function	GO:0005515	protein binding	Numb	IPI	RGD:2517	Rat	PMID:16394100\|RGD:2302413
Cellular Component	GO:0045177	apical part of cell	Numb	IDA		Mouse	PMID:12361975
Cellular Component	GO:0045177	apical part of cell	Numb	IDA		Mouse	PMID:21385765
Cellular Component	GO:0045177	apical part of cell	Numb	IDA		Rat	PMID:12702648\|RGD:2302414
Cellular Component	GO:0016323	basolateral plasma membrane	Numb	IDA		Mouse	PMID:17589506
Cellular Component	GO:0016323	basolateral plasma membrane	numb	IDA		Zfish	PMID:16493689
Cellular Component	GO:0005905	clathrin-coated pit	Numb	IDA		Mouse	PMID:26437238
Cellular Component	GO:0030136	clathrin-coated vesicle	NUMB	IDA		Human	PMID:19581412
Cellular Component	GO:0005737	cytoplasm	numb	IDA		Zfish	PMID:16493689
Cellular Component	GO:0031410	cytoplasmic vesicle	Numb	IDA		Mouse	MGI:MGI:5607220\|PMID:22174158
Cellular Component	GO:0043197	dendritic spine	Numb	IDA		Rat	PMID:16394100\|RGD:2302413
Cellular Component	GO:0005769	early endosome	Numb	IDA		Mouse	PMID:11782429
Cellular Component	GO:0005925	focal adhesion	NUMB	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Numb	IDA		Mouse	PMID:26621723
Cellular Component	GO:0098978	glutamatergic synapse	Numb	IMP		Mouse	PMID:26621723
Cellular Component	GO:0098978	glutamatergic synapse	Numb	IEP		Mouse	PMID:26621723
Cellular Component	GO:0098978	glutamatergic synapse	Numb	IDA		Rat	PMID:16394100\|RGD:2302413
Cellular Component	GO:0098978	glutamatergic synapse	Numb	IMP		Rat	PMID:16394100\|RGD:2302413
Cellular Component	GO:0005886	plasma membrane	numb	IDA		Zfish	PMID:16493689
Cellular Component	GO:0014069	postsynaptic density	Numb	IDA		Rat	PMID:16394100\|RGD:2302413
Cellular Component	GO:0014069	postsynaptic density	Numb	IMP		Rat	PMID:16394100\|RGD:2302413
Biological Process	GO:0034332	adherens junction organization	Numb	IGI	MGI:MGI:894702	Mouse	PMID:17589506
Biological Process	GO:0007409	axonogenesis	Numb	IDA		Mouse	PMID:15598981
Biological Process	GO:0007409	axonogenesis	Numb	IMP	MGI:MGI:1932085	Mouse	PMID:15598981
Biological Process	GO:0007368	determination of left/right symmetry	numb	IMP	ZFIN:ZDB-MRPHLNO-180926-1	Zfish	PMID:29843777
Biological Process	GO:0030900	forebrain development	Numb	IMP	MGI:MGI:1932085	Mouse	PMID:14687546
Biological Process	GO:0021670	lateral ventricle development	Numb	IMP		Mouse	MGI:MGI:3763347\|PMID:17174898
Biological Process	GO:0060487	lung epithelial cell differentiation	Numb	IMP		Mouse	PMID:21385765
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Numb	IMP		Mouse	PMID:21385765
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	NUMB	IMP		Human	PMID:19581412
Biological Process	GO:0007399	nervous system development	Numb	IMP	MGI:MGI:1932086	Mouse	PMID:10841580
Biological Process	GO:0007399	nervous system development	Numb	IMP	MGI:MGI:1932085	Mouse	PMID:14687546
Biological Process	GO:0021849	neuroblast division in subventricular zone	Numb	IMP		Mouse	MGI:MGI:3763347\|PMID:17174898
Biological Process	GO:0007405	neuroblast proliferation	Numb	IGI	MGI:MGI:894702	Mouse	PMID:12410312
Biological Process	GO:0030335	positive regulation of cell migration	NUMB	IGI	UniProtKB:P98082	Human	PMID:19581412
Biological Process	GO:0030335	positive regulation of cell migration	NUMB	IMP		Human	PMID:19581412
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Numb	IMP		Rat	PMID:16394100\|RGD:2302413
Biological Process	GO:0050769	positive regulation of neurogenesis	Numb	IMP		Mouse	MGI:MGI:2389562\|PMID:12410312
Biological Process	GO:0030862	positive regulation of polarized epithelial cell differentiation	Numb	IMP		Mouse	PMID:21385765
Biological Process	GO:0060319	primitive erythrocyte differentiation	numb	IGI	ZFIN:ZDB-MRPHLNO-110203-2	Zfish	PMID:21179188
Biological Process	GO:0060319	primitive erythrocyte differentiation	numb	IMP	ZFIN:ZDB-MRPHLNO-110114-3	Zfish	PMID:21179188
Biological Process	GO:0045664	regulation of neuron differentiation	Numb	IMP		Rat	PMID:8805372\|RGD:2302415
Biological Process	GO:0150052	regulation of postsynapse assembly	Numb	IDA		Rat	PMID:16394100\|RGD:2302413
Biological Process	GO:0150052	regulation of postsynapse assembly	Numb	IMP		Rat	PMID:16394100\|RGD:2302413
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Numb	IDA		Mouse	PMID:26621723
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Numb	IEP		Mouse	PMID:26621723
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Numb	IMP		Mouse	PMID:26621723

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.