Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NUPR1
  • Mouse genes Nupr1
  • Rat genes Nupr1
  • Zfish genes nupr1a,nupr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nupr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010698	acetyltransferase activator activity	Nupr1	IMP		Mouse	MGI:MGI:4360820|PMID:19723804
Molecular Function	GO:0003682	chromatin binding	Nupr1	IDA		Mouse	PMID:19723804
Molecular Function	GO:0003677	DNA binding	NUPR1	IDA		Human	PMID:11056169
Molecular Function	GO:0003677	DNA binding	NUPR1	IDA		Human	PMID:18690848
Molecular Function	GO:0060090	molecular adaptor activity	NUPR1	EXP		Human	PMID:11056169
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:Q09472	Human	PMID:11940591
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:Q6ZW49	Human	PMID:11940591
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:Q92905	Human	PMID:16300740
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:P06454	Human	PMID:16478804
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:P04637	Human	PMID:18690848
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:P04637,UniProtKB:Q09472	Human	PMID:18690848
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:P10085	Human	PMID:19723804
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:O43524	Human	PMID:20181828
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:Q99496	Human	PMID:28720707
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:O15534	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:P17655	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	NUPR1	IPI	UniProtKB:Q494V2-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Nupr1	IPI	PR:P10085	Mouse	PMID:19723804
Molecular Function	GO:0005515	protein binding	Nupr1	IPI	PR:Q61656	Mouse	PMID:19723804
Molecular Function	GO:0005515	protein binding	Nupr1	IPI	PR:B2RWS6	Mouse	PMID:19723804
Molecular Function	GO:0003713	transcription coactivator activity	NUPR1	IMP		Human	PMID:11940591
Cellular Component	GO:0005737	cytoplasm	NUPR1	IDA		Human	PMID:16300740
Cellular Component	GO:0045171	intercellular bridge	NUPR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	NUPR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	NUPR1	IDA		Human	PMID:10092851
Cellular Component	GO:0005634	nucleus	NUPR1	IDA		Human	PMID:16300740
Cellular Component	GO:0048471	perinuclear region of cytoplasm	NUPR1	IDA		Human	PMID:16300740
Cellular Component	GO:0032993	protein-DNA complex	NUPR1	IDA		Human	PMID:11056169
Biological Process	GO:0002526	acute inflammatory response	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:14660681
Biological Process	GO:0071391	cellular response to estrogen stimulus	nupr1b	IDA		Zfish	PMID:18618001
Biological Process	GO:0071470	cellular response to osmotic stress	nupr1b	IDA		Zfish	PMID:20036747
Biological Process	GO:0071467	cellular response to pH	nupr1b	IDA		Zfish	PMID:20036747
Biological Process	GO:0009267	cellular response to starvation	nupr1b	IDA		Zfish	PMID:20036747
Biological Process	GO:0071502	cellular response to temperature stimulus	nupr1b	IDA		Zfish	PMID:20036747
Biological Process	GO:0044346	fibroblast apoptotic process	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:11896600
Biological Process	GO:0048144	fibroblast proliferation	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:11896600
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:11896600
Biological Process	GO:0008584	male gonad development	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:18495683
Biological Process	GO:0043066	negative regulation of apoptotic process	NUPR1	IMP		Human	PMID:16478804
Biological Process	GO:0043066	negative regulation of apoptotic process	NUPR1	IMP		Human	PMID:30451898
Biological Process	GO:1902902	negative regulation of autophagosome assembly	NUPR1	IMP		Human	PMID:20181828
Biological Process	GO:0010507	negative regulation of autophagy	NUPR1	IMP		Human	PMID:20181828
Biological Process	GO:0010507	negative regulation of autophagy	Nupr1	IMP		Mouse	MGI:MGI:6283395|PMID:20181828
Biological Process	GO:0010507	negative regulation of autophagy	Nupr1	IMP		Rat	PMID:20181828|RGD:14390062
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	NUPR1	IMP		Human	PMID:20181828
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Nupr1	IMP		Rat	PMID:20181828|RGD:14390062
Biological Process	GO:0045786	negative regulation of cell cycle	NUPR1	IMP		Human	PMID:19723804
Biological Process	GO:0045786	negative regulation of cell cycle	Nupr1	IMP		Mouse	PMID:19723804
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	NUPR1	IMP		Human	PMID:20181828
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Nupr1	IMP		Rat	PMID:20181828|RGD:14390062
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	Nupr1	IMP		Mouse	MGI:MGI:6282976|PMID:27451286
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Nupr1	IMP		Mouse	MGI:MGI:6282976|PMID:27451286
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:11896600
Biological Process	GO:0045820	negative regulation of glycolytic process	NUPR1	IMP		Human	PMID:30451898
Biological Process	GO:0062099	negative regulation of programmed necrotic cell death	NUPR1	IMP		Human	PMID:30451898
Biological Process	GO:1904691	negative regulation of type B pancreatic cell proliferation	Nupr1	IMP		Mouse	MGI:MGI:5528565|PMID:23900510
Biological Process	GO:0045787	positive regulation of cell cycle	NUPR1	IDA		Human	PMID:10092851
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:11896600
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	NUPR1	IMP		Human	PMID:27031958
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Nupr1	IMP		Rat	PMID:27031958|RGD:14390051
Biological Process	GO:0150078	positive regulation of neuroinflammatory response	Nupr1	IMP		Mouse	MGI:MGI:4418805|PMID:16374777
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Nupr1	IMP		Rat	PMID:28694771|RGD:14390049
Biological Process	GO:1903862	positive regulation of oxidative phosphorylation	NUPR1	IMP		Human	PMID:30451898
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	NUPR1	IMP		Human	PMID:16300740
Biological Process	GO:0031401	positive regulation of protein modification process	Nupr1	IMP		Mouse	PMID:19723804
Biological Process	GO:0006473	protein acetylation	Nupr1	IMP		Mouse	PMID:19723804
Biological Process	GO:0065003	protein-containing complex assembly	Nupr1	IMP		Mouse	PMID:19723804
Biological Process	GO:0010506	regulation of autophagy	Nupr1	IMP		Rat	PMID:28694771|RGD:14390049
Biological Process	GO:2000194	regulation of female gonad development	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:18495683
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	NUPR1	IMP		Human	PMID:30451898
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	Nupr1	IMP		Rat	PMID:28694771|RGD:14390049
Biological Process	GO:0009636	response to toxic substance	Nupr1	IMP	MGI:MGI:3784016	Mouse	PMID:14660681
Biological Process	GO:0035914	skeletal muscle cell differentiation	Nupr1	IMP		Mouse	PMID:19723804

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern