Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OAS3
  • Mouse genes Oas3
  • Rat genes Oas3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oas3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	OAS3	IDA		Human	PMID:25275129
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	OAS3	IDA		Human	PMID:9880533
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	Oas3	IDA		Mouse	PMID:12396720
Molecular Function	GO:0005524	ATP binding	OAS3	IDA		Human	PMID:9880533
Molecular Function	GO:0003725	double-stranded RNA binding	OAS3	IDA		Human	PMID:25275129
Molecular Function	GO:0003725	double-stranded RNA binding	OAS3	IDA		Human	PMID:9880533
Molecular Function	GO:0003725	double-stranded RNA binding	Oas3	IDA		Mouse	PMID:12396720
Molecular Function	GO:0005515	protein binding	OAS3	IPI	UniProtKB:P56537	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	OAS3	IPI	UniProtKB:Q12894	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	OAS3	IPI	UniProtKB:Q7L2E3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	OAS3	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	OAS3	IPI	UniProtKB:Q8IY81	Human	PMID:21903422
Cellular Component	GO:0005737	cytoplasm	OAS3	IDA		Human	PMID:19923450
Cellular Component	GO:0005737	cytoplasm	OAS3	IDA		Human	PMID:9880533
Cellular Component	GO:0005829	cytosol	OAS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005615	extracellular space	OAS3	HDA		Human	PMID:23580065
Cellular Component	GO:0005654	nucleoplasm	OAS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	OAS3	IDA		Human	GO_REF:0000052
Biological Process	GO:0042742	defense response to bacterium	OAS3	IMP		Human	PMID:30822544
Biological Process	GO:0051607	defense response to virus	OAS3	IDA		Human	PMID:19923450
Biological Process	GO:0051607	defense response to virus	OAS3	IDA		Human	PMID:23196181
Biological Process	GO:0039530	MDA-5 signaling pathway	OAS3	IMP		Human	PMID:30078389
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	OAS3	IMP		Human	PMID:30078389
Biological Process	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	OAS3	IMP		Human	PMID:30078389
Biological Process	GO:0035395	negative regulation of chemokine (C-X-C motif) ligand 9 production	OAS3	IMP		Human	PMID:30078389
Biological Process	GO:0071659	negative regulation of IP-10 production	OAS3	IMP		Human	PMID:30078389
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	OAS3	IMP		Human	PMID:30078389
Biological Process	GO:0045071	negative regulation of viral genome replication	OAS3	IDA		Human	PMID:19056102
Biological Process	GO:0045071	negative regulation of viral genome replication	OAS3	IDA		Human	PMID:19923450
Biological Process	GO:0045071	negative regulation of viral genome replication	OAS3	IDA		Human	PMID:23196181
Biological Process	GO:0032728	positive regulation of interferon-beta production	OAS3	IMP		Human	PMID:30822544
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	OAS3	IMP		Human	PMID:30822544
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	OAS3	IMP		Human	PMID:30822544
Biological Process	GO:0060700	regulation of ribonuclease activity	OAS3	IDA		Human	PMID:19923450
Biological Process	GO:0060700	regulation of ribonuclease activity	OAS3	IDA		Human	PMID:25275129
Biological Process	GO:0009615	response to virus	OAS3	IDA		Human	PMID:19056102
Biological Process	GO:0039529	RIG-I signaling pathway	OAS3	IMP		Human	PMID:30078389

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern