Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OCA2
  • Mouse genes Oca2
  • Rat genes Oca2
  • Zfish genes oca2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oca2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0061778	intracellular chloride channel activity	OCA2	IDA		Human	PMID:25513726
Molecular Function	GO:0005515	protein binding	OCA2	IPI	UniProtKB:O43747	Human	PMID:19116314
Molecular Function	GO:0005515	protein binding	OCA2	IPI	UniProtKB:O95782	Human	PMID:19116314
Molecular Function	GO:0005515	protein binding	OCA2	IPI	UniProtKB:Q9Y2T2	Human	PMID:19116314
Cellular Component	GO:0005789	endoplasmic reticulum membrane	OCA2	IDA		Human	PMID:19116314
Cellular Component	GO:0010008	endosome membrane	OCA2	IDA		Human	PMID:19116314
Cellular Component	GO:0005765	lysosomal membrane	OCA2	IDA		Human	PMID:19116314
Cellular Component	GO:0033162	melanosome membrane	OCA2	IDA		Human	PMID:19116314
Biological Process	GO:0008283	cell population proliferation	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:9548375
Biological Process	GO:0048066	developmental pigmentation	Oca2	IMP	MGI:MGI:1856123	Mouse	PMID:11756244
Biological Process	GO:0050935	iridophore differentiation	oca2	IMP	ZFIN:ZDB-GENO-140619-2	Zfish	PMID:24330346
Biological Process	GO:0035752	lysosomal lumen pH elevation	OCA2	IDA		Human	PMID:25513726
Biological Process	GO:0035752	lysosomal lumen pH elevation	OCA2	IDA		Human	PMID:32966160
Biological Process	GO:0042438	melanin biosynthetic process	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:7665913
Biological Process	GO:0042438	melanin biosynthetic process	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:9548375
Biological Process	GO:0042438	melanin biosynthetic process	oca2	IMP	ZFIN:ZDB-GENO-140619-2	Zfish	PMID:24330346
Biological Process	GO:0006583	melanin biosynthetic process from tyrosine	OCA2	IDA		Human	PMID:25513726
Biological Process	GO:0006583	melanin biosynthetic process from tyrosine	OCA2	IDA		Human	PMID:32966160
Biological Process	GO:0030318	melanocyte differentiation	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:2379821
Biological Process	GO:0030318	melanocyte differentiation	oca2	IMP	ZFIN:ZDB-GENO-140619-2	Zfish	PMID:24330346
Biological Process	GO:0043473	pigmentation	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:9548375
Biological Process	GO:0043473	pigmentation	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:2379821
Biological Process	GO:0043473	pigmentation	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:13943454
Biological Process	GO:0043473	pigmentation	Oca2	IMP	MGI:MGI:1856114	Mouse	PMID:17247639
Biological Process	GO:0043473	pigmentation	oca2	IMP	ZFIN:ZDB-MRPHLNO-160722-2	Zfish	PMID:26744415
Biological Process	GO:0007286	spermatid development	Oca2	IMP	MGI:MGI:1856122	Mouse	PMID:7317942

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern