Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Opa1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes OPA1
- Mouse genes Opa1
- Rat genes Opa1
- Zfish genes opa1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Opa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1901612	cardiolipin binding	OPA1	IDA		Human	PMID:20185555
Molecular Function	GO:0003924	GTPase activity	OPA1	IDA		Human	PMID:20185555
Molecular Function	GO:0003924	GTPase activity	OPA1	IDA		Human	PMID:27667664
Molecular Function	GO:0019900	kinase binding	Opa1	IPI	RGD:1591334	Rat	PMID:23150663\|RGD:13209141
Molecular Function	GO:0070300	phosphatidic acid binding	OPA1	IDA		Human	PMID:20185555
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q12983	Human	PMID:20436456
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q16891	Human	PMID:21081504
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q9Y255	Human	PMID:21364629
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q5S007	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q9NTG7	Human	PMID:24344202
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q96I51	Human	PMID:28746876
Molecular Function	GO:0005515	protein binding	OPA1	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	Opa1	IPI	UniProtKB:Q9CYF5	Mouse	MGI:MGI:6104022\|PMID:28746876
Molecular Function	GO:0005515	protein binding	Opa1	IPI	UniProtKB:Q9CRB9	Mouse	MGI:MGI:5009773\|PMID:21081504
Molecular Function	GO:0044877	protein-containing complex binding	Opa1	IDA		Rat	PMID:20678484\|RGD:13204842
Cellular Component	GO:0005829	cytosol	OPA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Opa1	IDA		Rat	PMID:19169378\|RGD:13208942
Cellular Component	GO:0030425	dendrite	Opa1	IDA		Mouse	MGI:MGI:2179175\|PMID:11847212
Cellular Component	GO:0016020	membrane	OPA1	HDA		Human	PMID:19946888
Cellular Component	GO:0030061	mitochondrial crista	OPA1	IDA		Human	PMID:12504110
Cellular Component	GO:0005743	mitochondrial inner membrane	Opa1	IMP		Mouse	MGI:MGI:3692706\|PMID:16839884
Cellular Component	GO:0005743	mitochondrial inner membrane	Opa1	IDA		Mouse	MGI:MGI:6104022\|PMID:28746876
Cellular Component	GO:0005743	mitochondrial inner membrane	Opa1	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	Opa1	IDA		Rat	PMID:16778770\|RGD:7800724
Cellular Component	GO:0005758	mitochondrial intermembrane space	OPA1	IDA		Human	PMID:17008324
Cellular Component	GO:0005758	mitochondrial intermembrane space	Opa1	IDA		Mouse	MGI:MGI:2179175\|PMID:11847212
Cellular Component	GO:0005741	mitochondrial outer membrane	OPA1	IDA		Human	PMID:12504110
Cellular Component	GO:0005739	mitochondrion	OPA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	OPA1	IDA		Human	PMID:17545159
Cellular Component	GO:0005739	mitochondrion	Opa1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Opa1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Opa1	IDA		Mouse	PMID:17035996
Cellular Component	GO:0005739	mitochondrion	Opa1	IDA		Mouse	PMID:11847212
Cellular Component	GO:0005739	mitochondrion	Opa1	IDA		Rat	PMID:16249510\|RGD:7800723
Cellular Component	GO:0005654	nucleoplasm	OPA1	IDA		Human	GO_REF:0000052
Biological Process	GO:0007568	aging	Opa1	IEP		Rat	PMID:20036683\|RGD:7829729
Biological Process	GO:0036444	calcium import into the mitochondrion	Opa1	IMP		Rat	PMID:24085037\|RGD:13208948
Biological Process	GO:0071333	cellular response to glucose stimulus	Opa1	IEP		Rat	PMID:27684054\|RGD:12436725
Biological Process	GO:0071456	cellular response to hypoxia	Opa1	IEP		Rat	PMID:27833818\|RGD:12910766
Biological Process	GO:1905232	cellular response to L-glutamate	Opa1	IEP		Rat	PMID:28761318\|RGD:13432138
Biological Process	GO:0090398	cellular senescence	OPA1	IDA		Human	PMID:17545159
Biological Process	GO:0043009	chordate embryonic development	opa1	IMP	ZFIN:ZDB-MRPHLNO-130417-2	Zfish	PMID:23516612
Biological Process	GO:0043009	chordate embryonic development	opa1	IMP	ZFIN:ZDB-MRPHLNO-130417-1	Zfish	PMID:23516612
Biological Process	GO:0090102	cochlea development	Opa1	IEP		Rat	PMID:17828551\|RGD:13208944
Biological Process	GO:0046039	GTP metabolic process	OPA1	IDA		Human	PMID:20185555
Biological Process	GO:0007007	inner mitochondrial membrane organization	OPA1	IDA		Human	PMID:12509422
Biological Process	GO:0048312	intracellular distribution of mitochondria	Opa1	IMP		Rat	PMID:19605646\|RGD:7800727
Biological Process	GO:0097749	membrane tubulation	OPA1	IDA		Human	PMID:20185555
Biological Process	GO:0008053	mitochondrial fusion	OPA1	IDA		Human	PMID:17545159
Biological Process	GO:0008053	mitochondrial fusion	OPA1	IMP		Human	PMID:20185555
Biological Process	GO:0008053	mitochondrial fusion	OPA1	IMP		Human	PMID:20436456
Biological Process	GO:0008053	mitochondrial fusion	Opa1	IMP		Mouse	MGI:MGI:6377920\|PMID:15899901
Biological Process	GO:0000002	mitochondrial genome maintenance	OPA1	IMP		Human	PMID:18158317
Biological Process	GO:0070584	mitochondrion morphogenesis	Opa1	IMP		Rat	PMID:19605646\|RGD:7800727
Biological Process	GO:0070584	mitochondrion morphogenesis	opa1	IMP	ZFIN:ZDB-MRPHLNO-130417-1	Zfish	PMID:23516612
Biological Process	GO:0007005	mitochondrion organization	OPA1	IMP		Human	PMID:21149567
Biological Process	GO:0007005	mitochondrion organization	Opa1	IDA		Rat	PMID:16778770\|RGD:7800724
Biological Process	GO:0043066	negative regulation of apoptotic process	OPA1	IDA		Human	PMID:12509422
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	OPA1	IGI	UniProtKB:P58281	Human	PMID:23453807
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Opa1	IMP		Mouse	MGI:MGI:5495588\|PMID:23453807
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	Opa1	IMP		Mouse	MGI:MGI:3692706\|PMID:16839884
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	OPA1	IMP		Human	PMID:21149567
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	Opa1	IMP		Mouse	MGI:MGI:3692706\|PMID:16839884
Biological Process	GO:0001843	neural tube closure	Opa1	IMP	MGI:MGI:3578528	Mouse	PMID:15755804
Biological Process	GO:1900078	positive regulation of cellular response to insulin stimulus	Opa1	IMP		Rat	PMID:24085037\|RGD:13208948
Biological Process	GO:1900006	positive regulation of dendrite development	Opa1	IMP		Rat	PMID:23543485\|RGD:7800725
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Opa1	IMP		Rat	PMID:19605646\|RGD:7800727
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Opa1	IMP		Rat	PMID:24085037\|RGD:13208948
Biological Process	GO:0010636	positive regulation of mitochondrial fusion	Opa1	IMP		Rat	PMID:22442078\|RGD:7829728
Biological Process	GO:0014042	positive regulation of neuron maturation	Opa1	IMP		Rat	PMID:23543485\|RGD:7800725
Biological Process	GO:0051259	protein complex oligomerization	OPA1	IDA		Human	PMID:20185555
Biological Process	GO:1904643	response to curcumin	Opa1	IEP		Rat	PMID:27801955\|RGD:12738369
Biological Process	GO:0051602	response to electrical stimulus	Opa1	IEP		Rat	PMID:26513006\|RGD:12910850
Biological Process	GO:0014850	response to muscle activity	Opa1	IEP		Rat	PMID:28536949\|RGD:12910705
Biological Process	GO:0031667	response to nutrient levels	Opa1	IEP		Rat	PMID:25336449\|RGD:12880438
Biological Process	GO:0060041	retina development in camera-type eye	Opa1	IEP		Rat	PMID:15505078\|RGD:1547836
Biological Process	GO:0055015	ventricular cardiac muscle cell development	opa1	IMP	ZFIN:ZDB-MRPHLNO-130417-1	Zfish	PMID:25022898
Biological Process	GO:0007601	visual perception	OPA1	IMP		Human	PMID:11017080

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.